Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

1963 • 1,214 citations

Hyperpolarizing Vasodilators Activate ATP-sensitive K ⁺ Channels in Arterial Smooth Muscle

1989 • 1,197 citations

Operational models of pharmacological agonism

1983 • 1,062 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein

1986 • 481 citations

The classification of drugs and drug receptors in isolated tissues.

1984 • 474 citations

The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.

1987 • 452 citations

Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels*

1983 • 402 citations

Perivascular Potassium and pH as Determinants of Local Pial Arterial Diameter in Cats

1972 • 286 citations

The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on ⁸⁶Rb efflux in rat blood vessels

1986 • 264 citations

Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle

1989 • 247 citations

Electrical and mechanical effects of BRL34915 in guinea‐pig isolated trachealis

1986 • 209 citations

In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.

1989 • 201 citations

Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.

1989 • 189 citations

Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.

1989 • 144 citations

Endothelium‐dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim

1988 • 138 citations

Properties of the cromakalim‐induced potassium conductance in smooth muscle cells isolated from the rabbit portal vein

1989 • 130 citations

Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea‐pig taenia caeci

1986 • 129 citations

Drug Receptors and their Function

1971 • 125 citations

Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.

1987 • 122 citations

Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat

1989 • 120 citations

Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea‐pig smooth muscle differs from that of glyceryl trinitrate

1987 • 117 citations

Effect of the K+ efflux stimulating vasodilator BRL 34915 on 86Rb+ efflux and spontaneous activity in guinea-pig portal vein

1987 • 100 citations

A Ca2+-activated K+ channel from rabbit aorta: modulation by cromakalim

1989 • 92 citations

The relaxant action of BRL 34915 in rat uterus

1987 • 84 citations

Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries

1988 • 72 citations

Responsiveness to potassium and calcium ions of isolated cerebral arteries

1974 • 64 citations

The potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques

1988 • 64 citations

Comparison of electrical properties of middle cerebral and mesenteric artery in cat

1980 • 62 citations

Pharmacology and regulation of ATP-sensitive K+ channels

1989 • 59 citations

Local Chemical, Neural, and Humoral Regulation of Cerebrovascular Resistance Vessels

1985 • 58 citations

Altered membrane properties of cerebral vascular smooth muscle following subarachnoid hemorrhage: an electrophysiological study. I. Changes in resting membrane potential (Em) and effect on the electrogenic pump potential contribution to Em.

1985 • 55 citations

The effects of cromakalim on ATP‐sensitive potassium channels in insulin‐secreting cells

1990 • 53 citations

Smooth muscle K+ channel openers; their pharmacology and clinical potential

1989 • 53 citations

Inhibition by sulphonylureas of vasorelaxation induced by K⁺ channel activators in vitro

1989 • 51 citations

The role of membrane depolarization in the contractile response of the rabbit basilar artery to 5‐hydroxytryptamine.

1987 • 48 citations

Effect of H+ and elevated PCO 2on membrane electrical properties of rat cerebral arteries

1982 • 44 citations

Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery

1991 • 43 citations

Evidence for the presence of 5-HT1-like receptors in rabbit isolated basilar arteries

1989 • 41 citations

Vasodilatation Induced by Pinacidil in Dogs. Comparison with Hydralazine and Nifedipine

1985 • 39 citations

Agonist potency and apparent affinity: interpretation using classical and steady-state ternary-complex models

1990 • 33 citations

Actions of Nicorandil on Vascular Smooth Muscles

1987 • 31 citations

Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations

1989 • 27 citations

Electromechanical coupling in feline basilar artery in response to serotonin

1983 • 25 citations

The effects of pinacidil and tolbutamide in feline pial arteries in situ

1989 • 20 citations

Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca²⁺

1989 • 20 citations

Pertussis toxin treatment does not inhibit the effects of the potassium channel opener BRL 34915 on rat isolated vascular and cardiac tissues

1988 • 19 citations

Cerebrovascular effects of prostanoids: In Vitro studies in feline middle cerebral and basilar artery

1989 • 19 citations

Inhibition of small intestine motility by cromakalim (BRL 34915)

1988 • 15 citations

Hyperpolarizing action of cromakalim on the rat aorta

1989 • 11 citations

GTP-binding proteins and their regulatory actions on ion channels.

1989 • 10 citations

Cerebrovascular effects of nimodipine in cats.

1989 • 2 citations