Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system—I. Amelioration of cognitive deficits by transplants into cortex and hippocampus but not into basal forebrain

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

The unbiased estimation of number and sizes of arbitrary particles using the disector

1984 • 2,539 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

The Hippocampus as a Cognitive Map

1979 • 1,966 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata

1988 • 1,209 citations

Neurobiology of the hippocampus

1984 • 1,096 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Latent inhibition.

1973 • 774 citations

Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats

1985 • 493 citations

The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type

1989 • 491 citations

Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation.

1983 • 403 citations

HISTOCHEMICAL METHODS FOR SEPARATE, CONSECUTIVE AND SIMULTANEOUS DEMONSTRATION OF ACETYLCHOLINESTERASE AND NOREPINEPHRINE IN CRYOSTAT SECTIONS

1967 • 400 citations

Medial septal area lesions disrupt theta rhythm and cholinergic staining in medial entorhinal cortex and produce impaired radial arm maze behavior in rats

1982 • 390 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments

1985 • 386 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats

1984 • 369 citations

Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes

1989 • 325 citations

Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions

1982 • 319 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

1988 • 289 citations

Memory impairments following basal forebrain lesions

1985 • 264 citations

Attention and the frontal cortex as examined by simultaneous temporal processing

1988 • 263 citations

Cholinergic system and memory in the rat: Effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of cholinergic basal forebrain projection system

1989 • 258 citations

Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus

1987 • 256 citations

Cellular and molecular basis of cholinergic function

1987 • 252 citations

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 • 247 citations

Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—II. Sensorimotor and learning impairments

1985 • 242 citations

Cholinergic-rich brain transplants reverse alcohol-induced memory deficits

1988 • 221 citations

Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: Differential dependence on cholinergic neuronal loss

1991 • 210 citations

The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

1988 • 210 citations

Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon

1989 • 206 citations

Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs

1986 • 197 citations

Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

1985 • 190 citations

The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional visual discrimination: Implications for cholinergic hypotheses of learning and memory

1987 • 183 citations

The Cholinergic Neurotransmitter System in Human Memory and Dementia: A Review

1986 • 179 citations

Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat

1988 • 171 citations

Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: Differential effects on cholinergic mechanisms

1989 • 162 citations

Profound disturbances of spontaneous and learned behaviors following lesions of the nucleus basalis magnocellularis in the rat

1985 • 154 citations

Acetylcholine release in the rat hippocampus as studied by microdialysis is dependent on axonal impulse flow and increases during behavioural activation

1990 • 149 citations

The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats

1991 • 142 citations

Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission

1989 • 137 citations

Effects of cholinergic depletion on neuron activities in the cat visual cortex

1987 • 130 citations

Cholinergic enhancement of direction selectivity in the visual cortex of the cat

1991 • 130 citations

Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning

1983 • 129 citations

Neural Transplantation in Animal Models of Dementia

1990 • 124 citations

Cholinergic receptor blockade produces impairments in a sensorimotor subsystem for place navigation in the rat: Evidence from sensory, motor, and acquisition tests in a swimming pool.

1987 • 121 citations

Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia.

1989 • 120 citations

Formation of cholinergic synapses by intrahippocampal septal grafts as revealed by choline acetyltransferase immunocytochemistry

1986 • 118 citations

Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance

1985 • 110 citations

Cholinergic grafts in the neocortex or hippocampus of aged rats: Reduction of delay-dependent deficits in the delayed non-matching to position task

1988 • 108 citations

Cholinergic-dopaminergic interactions in cognitive performance

1990 • 102 citations

Catecholamine System Involvement in Age‐related Memory Dysfunction

1985 • 98 citations

Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia.

1989 • 98 citations

Cholinergic receptor blockade produces impairments in a sensorimotor subsystem for place navigation in the rat: Evidence from sensory, motor, and acquisition tests in a swimming pool.

1987 • 98 citations

Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system—II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery

1991 • 97 citations

Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets

1985 • 95 citations

Scopolamine degrades spatial working memory but spares spatial reference memory: Dissimilarity of anticholinergic effect and restriction of distal visual cues

1985 • 94 citations

Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen

1989 • 94 citations

Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease

1986 • 94 citations

Drugs as Research Tools in Psychology: Cholinergic Drugs and Information Processing

1984 • 86 citations

Effects of nicotine on biological systems

1990 • 86 citations

Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants.

1983 • 80 citations

Similar memory impairments found in medial septal-vertical diagonal band of Broca and nucleus basalis lesioned rats: Are memory defects induced by nucleus basalis lesions related to the degree of non-specific subcortical cell loss?

1990 • 80 citations

Behavioral deficits after intrahippocampal fetal septal grafts in rats with selective fimbria-fornix lesions

1988 • 78 citations

Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of meynert in the rat

1985 • 77 citations

Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions

1986 • 76 citations

Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain.

1985 • 74 citations

Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats

1986 • 74 citations

Transplantation of embryonic ventral forebrain grafts to the neocortex of rats with bilateral lesions of nucleus basalis magnocellularis ameliorates a lesion-induced deficit in spatial memory

1988 • 72 citations

Cholinergic blockade in the rat impairs strategy selection but not learning and retention of nonspatial visual discrimination problems in a swimming pool.

1988 • 71 citations

Reassessing the cholinergic basal forebrain: nomenclature schemata and concepts

1989 • 69 citations

Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain.

1985 • 67 citations

Topographic projections to the visual cortex from the basal forebrain in the rat

1987 • 61 citations

Cholinergic blockade in the rat impairs strategy selection but not learning and retention of nonspatial visual discrimination problems in a swimming pool.

1988 • 58 citations

Korsakoff's psychosis: Noradrenergic systems and cognitive impairment

1983 • 55 citations

Effects of proactive interference on rats’ continuous nonmatching-to-sample performance

1983 • 55 citations

Raphe cells grafted into the hippocampus can ameliorate spatial memory deficits in rats with combined serotonergic/cholinergic deficiencies

1989 • 51 citations

Neural Grafting in the Aged Rat Brain

1986 • 43 citations

Specific Brain Protein Changes Correlated with Behaviourally Effective Brain Transplants

1991 • 41 citations

Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets

1990 • 37 citations

Improved radial maze performance induced by the benzodiazepine antagonist ZK 93 426 in lesioned and alcohol-treated rats

1989 • 36 citations

Evidence against a specific effect of cholinergic drugs on spatial memory in primates

1991 • 36 citations

The effects of ibotenic acid lesions of the nucleus basalis and cholinergic-rich neural transplants on win-stay/lose-shift and win-shift/lose-stay performance in the rat

1990 • 35 citations

Chapter 7 Grafts, growth factors and grafts that make growth factors

1990 • 34 citations

Cognitive Models and Cholinergic Drugs

1989 • 31 citations

Susceptibility to pentylenetetrazol-induced and audiogenic seizures in rats with selective fimbria-fornix lesions and intrahippocampal septal grafts

1987 • 28 citations

Neuronal grafting and alzheimer's disease

1990 • 21 citations

Functional recovery following transplants of embryonic brain tissue in rats with lesions of visual, frontal and motor cortex: Problems and prospects for future research

1990 • 13 citations

The role of the Forebrain Cholinergic Projection System in Performance in the Radial-Arm Maze in Memory-Impaired Rats

1991 • 12 citations

Deleterious and “Overshoot” Effects of Intracerebral Transplants

1989 • 11 citations

Chapter 36 Acetylcholine release from intrahippocampal septal grafts is under control by the host brain: a microdialysis study

1990 • 8 citations

Neural transplantation.

1990 • 7 citations

Chapter 6 Behavioural recovery following transplantation of the neuroblastoma cell line IMR-32

1990 • 6 citations