Mechanisms of Biologic Aging

Superoxide Dismutase

1969 • 12,578 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

GLUTATHIONE

1983 • 5,487 citations

Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

The Rate of Living.

1928 • 686 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Microbodies-Peroxisomes and Glyoxysomes

1971 • 549 citations

Regulation of the pentose phosphate cycle

1974 • 439 citations

Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds

1971 • 382 citations

Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.

1984 • 372 citations

Progressive dendritic changes in aging human cortex

1975 • 367 citations

Aspartic acid racemisation in the human lens during ageing and in cataract formation

1977 • 348 citations

Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster

1976 • 324 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Free radicals in molecular biology, aging, and disease

1985 • 271 citations

ON THE INFLUENCE OF FOOD AND TEMPERATURE UPON THE DURATION OF LIFE

1917 • 268 citations

Glutathione Peroxidase Brought into Focus

1982 • 267 citations

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

1975 • 250 citations

Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen

1983 • 227 citations

Structure of carbohydrate of hemoglobin AIc.

1977 • 225 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

Insect Flight Metabolism

1978 • 223 citations

Glucosylation of human collagen in aging and diabetes mellitus.

1980 • 208 citations

Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein

1985 • 203 citations

Accumulation of D-Aspartic Acid with Age in the Human Brain

1983 • 196 citations

Peroxisomes: new aspects of cell physiology and biochemistry.

1977 • 192 citations

Metabolism and functions of glutathione

1981 • 190 citations

Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissue

1977 • 182 citations

Superoxide Radical and Superoxide Dismutases: Threat and Defense

1980 • 178 citations

The control of muscle and cartilage development in the chick limb: the role of differential vascularization

1973 • 176 citations

Nonenzymatic glycosylation of hemoglobin.

1977 • 176 citations

Oxygen and Living Processes

1981 • 171 citations

Reduction of paraquat toxicity by superoxide dismutase

1974 • 165 citations

Transplantation of Pluripotential Nuclei from Triploid Frog Tumors

1969 • 160 citations

Hibernation and Longevity in the Turkish Hamster Mesocricetus brandti

1981 • 154 citations

Changes in the mechanisms of hormone and neurotransmitter action during aging: Current status of the role of receptor and post-receptor alterations. A review

1982 • 153 citations

The effect of oxygen tension on the growth and metabolism of WI‐38 cells

1976 • 151 citations

Testing the Theories of Aging

1983 • 132 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

Oxygen toxicity in the perfused rat liver and lung under hyperbaric conditions

1976 • 127 citations

Antioxidants, lipid peroxidation and chemical-induced liver injury.

1973 • 122 citations

Advances in Enzyme Regulation

2001 • 120 citations

Experimental Studies on the Duration of Life. XII. Influence of Temperature during the Larval Period and Adult Life on the Duration of the Life of the Imago of Drosophila melanogaster

1929 • 117 citations

Gene activation in somatic nuclei after injection into amphibian oocytes.

1977 • 116 citations

Oxygen free‐radicals and lipid peroxidation: inhibition by the protein caeruloplasmin

1980 • 116 citations

The Rate of Living Theory: A Contemporary Interpretation

1986 • 114 citations

Oxygen modulates growth of human cells at physiologic partial pressures.

1984 • 111 citations

Theoretical of Aspects of Aging

1974 • 109 citations

Detection of an advanced glycosylation product bound to protein in situ.

1985 • 106 citations

Oxygen-induced changes in pulmonary superoxide dismutase assayed by antibody titrations

1976 • 105 citations

Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

1979 • 102 citations

Mating behavior, physical activity and aging in the housefly, Musca domestica

1973 • 98 citations

The Oxygen Consumption of Flies During Flight

1940 • 95 citations

Activation of Dormant Genes in Specialized Cells

1984 • 88 citations

Effect of catalase inactivation on levels of inorganic peroxides, superoxide dismutase, glutathione, oxygen consumption and life span in adult houseflies (Musca domestica)

1983 • 88 citations

The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro.

1977 • 86 citations

Recognition and Uptake of Human Diabetic Peripheral Nerve Myelin by Macrophages

1985 • 76 citations

Molecular biology of aging

1985 • 73 citations

Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity

1979 • 66 citations

Considerations on the Role of Aspartic Acid Racemization in the Aging Process

1977 • 65 citations

INTAKE AND ABSORPTION OF TOCOPHEROL*

1972 • 63 citations

Metabolic activity and duration of life. II. Metabolic rates and their relation to longevity in Daphnia magna

1929 • 62 citations

The Glutathione–Glutathione Disulfide System

1976 • 61 citations

Nonenzymatic Glycosylation and Browning in Diabetes and Aging: Studies on Lens Proteins

1982 • 61 citations

Enhancement of mitochondrial, cyanide-resistant superoxide dismutase in the livers of rats treated with 2,4-dinitrophenol.

1980 • 60 citations

Detection of nonenzymatic browning products in the human lens

1983 • 60 citations

Modification of proteins during aging.

1986 • 50 citations

Variation of superoxide dismutases during the development of the fruit fly Ceratitis capitata L

1976 • 49 citations

Increase in the longevity of adult Drosophila melanogaster kept in permanent darkness

1973 • 49 citations

Oxygen consumption and life span in the adult male housefly, Musca domestica

1982 • 36 citations

Enzyme Distribution in Potato Mitochondria

1979 • 35 citations

Autoimmunity, histocompatibility, and aging

1979 • 35 citations

Studies on the biochemical basis of oxygen toxicity

1973 • 34 citations

The establishment of vascular-derived microenvironments in the developing chick wing

1983 • 34 citations

CROSSLINKAGE AND THE AGING PROCESS

1974 • 33 citations

Glutathione content of human skin carcinomas

1976 • 32 citations

Senescence in Drosophila—II. Renewal of catalase activity in flies of different ages

1973 • 30 citations

Lipid and steroid hydroperoxides as substrates for the non-selenium-dependent glutathione peroxidase

1979 • 26 citations

Effects of washing and osmotic shock on catalase activity of intact chloroplast preparations

1977 • 26 citations

METABOLISM AS RELATED TO CHROMOSOME STRUCTURE AND THE DURATION OF LIFE

1931 • 23 citations

Involvement of Glutathione in the Differentiation of the Slime Mold Physarum polycephalum

1985 • 23 citations

CARBON DIOXIDE PRODUCTION AND DURATION OF LIFE OF DROSOPHILA CULTURES

1926 • 19 citations

Dysdifferentiative nature of aging: age-dependent expression of mouse mammary tumor virus and casein genes in brain and liver tissues of the C57BL/6J mouse strain

1985 • 18 citations

Metabolism of toxic substances in isolated hepatocytes

1980 • 13 citations

Temperature and Longevity in Male Rats

1966 • 12 citations

The Effect of Transition Metal Ions on the Resistance of Bacterial Spores to Hydrogen Peroxide and to Heat

1979 • 11 citations

Accelerated Aging due to Enzymatic Racemization

1978 • 8 citations

Acetaminophen toxicity increases with aging in the mosquito

1982 • 4 citations

Non‐enzymatic modification of proteins by steroids: Pathological implications for autoimmunity and glucocorticoid toxicity

1985 • 4 citations

Free Radicals in Biology, Volume 6

1985 • 3 citations

Free Radicals in Biology, Volume 3

1979 • 3 citations

Free Radicals in Biology, Volume 5

1982 • 2 citations

Deleted Work

1955 • 0 citations