Detection and quantification of melphalan-DNA adducts at the single cell level in hematopoietic tumor cells

The comet assay: a comprehensive review

1995 • 1,690 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

Factors influencing DNA migration from individual cells subjected to gel electrophoresis

1992 • 370 citations

DNA adducts from chemotherapeutic agents

1996 • 288 citations

Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies

1992 • 200 citations

Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.

1978 • 154 citations

Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells.

1987 • 130 citations

Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease

1978 • 99 citations

Application of new techniques for the detection of carcinogen adducts to human population monitoring

1988 • 84 citations

Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody.

1991 • 68 citations

Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking

1993 • 66 citations

Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections.

1987 • 64 citations

Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum.

1990 • 54 citations

Drug-induced DNA modification in buccal cells of cancer patients receiving carboplatin and cisplatin combination chemotherapy, as determined by an immunocytochemical method: interindividual variation and correlation with disease response.

1993 • 52 citations

Immunological detection of DNA damage caused by melphalan using monoclonal antibodies.

1987 • 51 citations

Monitoring of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in cells from platinum-treated cancer patients.

1988 • 47 citations

Antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA: Applications for detection of xenobiotics in biological samples

1993 • 45 citations

Immunohistochemical quantitation of polycyclic aromatic hydrocarbon-DNA adducts in human lymphocytes.

1995 • 39 citations

Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards.

1986 • 39 citations

Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence

1993 • 34 citations

Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level

1994 • 30 citations

Cytotoxicity as an indicator for transport mechanism: evidence that murine bone marrow progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells

1980 • 28 citations

Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity

1992 • 26 citations

25th Paterson Symposium – is there a future for radiosensitivity testing?

1991 • 25 citations

Antibodies to DNA alkylation addcuts as analytical tools in chemical carcinogenesis

1990 • 25 citations

Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: Characterization of mono-alkylated and cross-linked products from reaction of melphalan with dGMP and GMP

1990 • 23 citations

Immunotoxins recognising a new epitope on the neural cell adhesion molecule have potent cytotoxic effects against small cell lung cancer

1994 • 20 citations

The reaction of melphalan with deoxyguanosine and deoxyguanylic acid

1992 • 14 citations

A monoclonal antibody that recognizes alkali-stabilized melphalan-DNA adducts and its application in immunofluorescence microscopy

1995 • 11 citations

Concepts of remission, curability and lineage involvement in relationship to the problems of minimal residual leukaemia

1991 • 5 citations