Anticoagulant Activity of Synthetic Hirudin Peptides

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

[10] Enzymatic hydrolysis with carboxypeptidases

1972 • 333 citations

[69] Hirudin as an inhibitor of thrombin

1970 • 311 citations

Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.

1986 • 198 citations

The complete amino acid sequence of hirudin, a thrombin specific inhibitor

1984 • 170 citations

Anion-binding exosite of human .alpha.-thrombin and fibrin(ogen) recognition

1988 • 161 citations

The functional domain of hirudin, a thrombin‐specific inhibitor

1983 • 151 citations

Identification of regions of .alpha.-thrombin involved in its interaction with hirudin

1987 • 122 citations

Antithrombin properties of C‐terminus of hirudin using synthetic unsulfated N^α‐acetyl‐hirudin_45–65

1987 • 108 citations

The Complete Covalent Structure of Hirudin. Localization of the Disulfide Bonds

1985 • 104 citations

The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics

1987 • 99 citations

Thrombin Active-Site Regions

1986 • 85 citations

The use of sequence-specific antibodies to identify a secondary binding site in thrombin.

1988 • 71 citations

Proton nuclear magnetic resonance study of hirudin: resonance assignment and secondary structure

1987 • 40 citations

The inhibition of the intrinsic generation of activated factor X by heparin and hirudin

1980 • 21 citations

Preparation of tyrosine-O-[35S]sulfated cholecystokinin octapeptide from a nonsulfated precursor peptide

1986 • 12 citations