Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210bcr/abl

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

A system of nomenclature for band patterns of mouse chromosomes

1973 • 368 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content.

1969 • 276 citations

Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line.

1982 • 227 citations

p53 in chronic myelogenous leukemia in acute phase.

1991 • 224 citations

The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity

1985 • 184 citations

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.

1990 • 174 citations

Cytogenetics of chronic myelogenous leukemia.

1988 • 164 citations

Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments]

1989 • 157 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

The structure of mutation in mammalian cells

1990 • 101 citations

GENOMIC ALTERATIONS INVOLVING THE C-MYC PROTO-ONCOGENE LOCUS DURING THE EVOLUTION OF A CASE OF CHRONIC GRANULOCYTIC LEUKAEMIA

1984 • 91 citations

Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent edomitosis in Fanconi anemia cells.

1985 • 89 citations

Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line.

1987 • 88 citations

Absence of the human retinoblastoma gene product in the megakaryoblastic crisis of chronic myelogenous leukemia

1991 • 81 citations

Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line.

1991 • 73 citations

Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia

1989 • 66 citations

Rare occurrence of N-ras point mutations in Philadelphia chromosome positive chronic myeloid leukemia

1989 • 65 citations

Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell.

1990 • 55 citations

Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations

1979 • 54 citations

Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis

1987 • 44 citations

Multiple steps are required for the induction of tumors by Abelson murine leukemia virus

1989 • 32 citations

High expression of ras p21 correlates with increased rate of abnormal mitosis in NIH3T3 cells.

1990 • 29 citations

Restoration of responsiveness of chronic myeloid leukemia granulocyte- macrophage colony-forming cells to growth regulation in vitro following preincubation with prostaglandin E

1983 • 27 citations

The v-src oncogene blocks the differentiation of a murine myeloid progenitor cell line and induces a tumorigenic phenotype.

1991 • 27 citations

A selectable temperature-sensitive v-src Moloney retrovirus.

1988 • 11 citations

Abelson Murine Leukemia Virus Induces Platelet-Derived Growth Factor-Independent Fibroblast Growth: Correlation with Kinase Activity and Dissociation from Full Morphologic Transformation

1989 • 9 citations

Phosphotyrosine phosphatase activity prevents the detection of P210bcr/abl protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique.

1989 • 7 citations

Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation

1989 • 7 citations

Modulation of responsiveness of chronic myelogenous leukemia granulocyte‐macrophage colony‐forming cells to growth regulation following in vivo treatment with recombinant γ‐interferon

1988 • 6 citations

Clonal succession and deletion of bcr/abl sequences in chronic myelogenous leukemia with recurrent lymphoid blast crisis.

1991 • 5 citations