Characterization of a Db-specific helper factor required for the induction of cytotoxic responses to alloantigens with the use of monoclonal antibodies specific for the helper factor or the T-cell antigen receptor.

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

1983 • 464 citations

Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues

1984 • 328 citations

A differentiation factor required for the expression of cytotoxic T-cell function

1982 • 163 citations

A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.

1977 • 122 citations

Mechanism of T cell activation. II. Antigen- and lectin-dependent acquisition of responsiveness to TCGF is a nonmitogenic, active response of resting T cells.

1981 • 115 citations

T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.

1984 • 108 citations

Hybrids between rat lymphoma and mouse T cells with inducible cytolytic activity

1982 • 81 citations

Presence of interchain disulfide bonds between two gene products that compose the secreted form of an antigen-specific suppressor factor.

1981 • 71 citations

The Biochemistry of Antigen-Specific T-Cell Factors

1983 • 60 citations

Activation of cytotoxic T lymphocytes requires at least two spleen cell-derived helper factors besides interleukin 2.

1983 • 56 citations

Quantitative studies on the precursors of cytotoxic lymphocytes. VI. Second signal requirements of specifically activated precursors isolated 12 h after stimulation.

1980 • 48 citations

Activation of resting T lymphocytes by a monoclonal antibody directed against an allotypic determinant on the T cell receptor

1986 • 46 citations

H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.

1981 • 45 citations

Three different signals are required for the induction of cytolytic T lymphocytes from resting precursors.

1983 • 43 citations

Signal requirements for the in vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL‐precursors, clonal growth and differentiation into cytotoxic effector cells

1985 • 39 citations

Selection of the T cell repertoire during ontogeny: Limiting dilution analysis

1982 • 39 citations

Antigen stimulation of cytolytic T lymphocyte precursors: minimal requirements for growth and acquisition of cytolytic activity

1985 • 35 citations

Analysis of the two-signal requirement for precursor cytolytic T lymphocyte activation using H-2Kk in liposomes.

1982 • 34 citations

The Biology of Monoclonal Lymphokines Secreted by T Cell Lines and Hybridomas

1982 • 33 citations

Requirement for the Involvement of Clonally Distributed Receptors in the Activation of Cytotoxic T Lymphocytes

1982 • 26 citations

Induction of proliferative and cytotoxic responses in resting Lyt‐2⁺ T cells with lectin and recombinant interleukin 2

1985 • 25 citations

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1.

1985 • 15 citations

The role of class II MHC molecules in the activation of class I-reactive T cell hybridomas.

1986 • 14 citations

Induction of cytotoxic lymphocyte responses by antigen-specific helper factors.

1984 • 11 citations

Antigen-specific soluble helper activity for murine major histocompatibility complex-encoded molecules. I. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity.

1982 • 9 citations

Induction of CTL responses to alloantigens by a Db-specific T helper clone.

1984 • 5 citations

Characteristics of an antigen-specific helper factor that enhances the in vitro generation of cytotoxic cells directed against a syngeneic tumor.

1981 • 2 citations