In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

1988 • 1,039 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.

1988 • 462 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.

1994 • 357 citations

In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.

1988 • 356 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.

1995 • 317 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

1991 • 261 citations

Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

1990 • 238 citations

Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis

1991 • 181 citations

Complete one-hour immunocytochemistry based on capillary action.

1992 • 156 citations

Expression of a Human Multidrug Resistance cDNA (MDR1) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-Induced Leukopenia

1989 • 151 citations

Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.

1994 • 136 citations

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1992 • 134 citations

Molecular cloning and characterization of the human E-cadherin cDNA

1993 • 113 citations

Different Growth Pattern and Biologic Behavior of Human Renal Cell Carcinoma Implanted Into Different Organs of Nude Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 108 citations

Organ-Specific Modulation of Steady-State mdr Gene Expression and Drug Resistance in Murine Colon Cancer Cells

1994 • 103 citations

A rapid colorimetric in situ messenger RNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas.

1993 • 94 citations

Chemical Synthesis and Biological Studies on Mutated Gene-control Regions

1983 • 89 citations

Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer

1994 • 79 citations

Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production

1992 • 78 citations

Increased expression of the 72-kd type IV collagenase in prostatic adenocarcinoma. Demonstration by immunohistochemistry and in situ hybridization.

1994 • 72 citations

A rapid colorimetric in situ mRNA hybridization technique using hyperbiotinylated oligonucleotide probes for analysis of mdr1 in mouse colon carcinoma cells.

1993 • 71 citations

Paracrine growth regulation of human colon carcinoma organ-specific metastasis

1993 • 61 citations

Amplification and rearrangement of the Kirsten ras oncogene in virus-transformed BALB/c 3T3 cells during malignant tumor progression.

1987 • 58 citations

Clonal Stimulation or Inhibition of Human Colon Carcinomas and Human Renal Carcinomas Mediated by Transforming Growth Factor-β 1

1989 • 49 citations

Growth factors and their receptors in metastasis.

1991 • 49 citations

Genetic regulation of metastatic progression.

1990 • 33 citations

Towards an understanding of the molecular basis of the metastatic phenotype.

1989 • 31 citations