Prospects for human monoclonal antibodies: a critical perspective.

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

1980 • 383 citations

Classification and biological nature of established human hematopoietic cell lines

1975 • 356 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Production of human hybridomas secreting antibodies to measles virus

1980 • 308 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

Immunological Specificity

1959 • 270 citations

On the Specificity of Antibodies

1975 • 217 citations

Efficiency of transformation of lymphocytes by Epstein-Barr virus

1977 • 206 citations

Somatic mutation of immunoglobulin light-chain variable-region genes

1981 • 184 citations

Diversity of germ-line immunoglobulin VH genes

1981 • 140 citations

Immunoglobulin chain loss in hybridoma lines.

1980 • 129 citations

Structure of Antibodies with Shared Idiotypy: The Complete Sequence of the Heavy Chain Variable Regions of Two Immunoglobulin M Anti-Gamma Globulins

1974 • 115 citations

Immunoglobulin expression by human B lymphocytes clonally transformed by Epstein Barr virus.

1982 • 78 citations

An experimental approach to enumerate the genes coding for immunoglobulin variable-regions

1981 • 31 citations

Immunoglobulins with multiple binding functions. II. The use of nylon-polyserine whisker discs in screening myeloma immunoglobulins for binding activity.

1974 • 27 citations

Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies

1981 • 19 citations

Why Hybridomas?

1981 • 6 citations