Why Hybridomas?

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Immunoglobulin-producing tumors and myeloma proteins of mice.

1972 • 518 citations

EB virus-induced B lymphocyte cell lines producing specific antibody

1977 • 390 citations

Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

1980 • 383 citations

Chromosomal location of the genes for human immunoglobulin heavy chains.

1979 • 368 citations

Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

1977 • 309 citations

Production of human hybridomas secreting antibodies to measles virus

1980 • 308 citations

High frequencies of antigen-specific hybridomas: dependence on immunization parameters and prediction by spleen cell analysis

1980 • 284 citations

Generation of human monoclonal antibodies reactive with human mammary carcinoma cells.

1980 • 255 citations

Pluripotent teratocarcinoma-thymus somatic cell hybrids

1976 • 216 citations

Evidence that murine pre-B cells synthesise μ heavy chains but no light chains

1979 • 208 citations

GENE EXPRESSION IN SOMATIC CELL HYBRIDS

1974 • 183 citations

Hybrid cell lines with T-cell characteristics

1977 • 146 citations

Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

1978 • 134 citations

Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.

1978 • 131 citations

Immunoglobulin chain loss in hybridoma lines.

1980 • 129 citations

Immunoglobulin M mutants

1980 • 119 citations

Production of Antibody to Tetanus Toxoid by Continuous Human Lymphoblastoid Cell Lines

1978 • 115 citations

Immunoglobulin production by lymphocyte hybridomas

1978 • 111 citations

Human Monoclonal Antibody Against Forssman Antigen

1980 • 111 citations

Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class.

1980 • 101 citations

Induction of Secretion of IgM from Cells of the B Cell Line 38C-13 by Somatic Cell Hybridization

1979 • 70 citations

Derivation of hybrids between a thymoma line and spleen cells activated in a mixed leukocyte reaction

1977 • 59 citations

Frequency of precursor cells against the enzyme β‐galactosidase An estimate of the BALB/c strain antibody repertoire

1976 • 53 citations

Co-expression of differentiation markers in hybrids between friend cells and lymphoid cells and the influence of the cell shape

1980 • 48 citations

Fusion of T and B cells

1977 • 48 citations

Identification and characterization of rabbit-mouse hybridomas secreting rabbit immunoglobulin chains.

1980 • 43 citations

Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas

1980 • 22 citations

Immunoglobulin µ and γ heavy chain classes are not determined by class-specific RNA-splicing enzymes

1978 • 18 citations

T cell clones: Their use for the study of specificity, induction, and effector-function of T cells

1980 • 17 citations

Transformation by Simian Virus 40 of Spleen Cells from a Hyperimmune Rabbit: Demonstration of Production of Specific Antibody to the Immunizing Antigen

1974 • 15 citations