The Ca2+ pumps and the Na+/Ca2+ exchangers.

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

The dependence of calcium efflux from cardiac muscle on temperature and external ion composition

1968 • 1,024 citations

Ion motive ATPases. I. Ubiquity, properties, and significance to cell function

1987 • 964 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Purification and Properties of an Adenosine Triphosphatase from Sarcoplasmic Reticulum

1970 • 835 citations

Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

1986 • 812 citations

Molecular Cloning and Functional Expression of the Cardiac Sarcolemmal Na ⁺ -Ca ²⁺ Exchanger

1990 • 751 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Regulation of Cardiac Na ⁺ ,Ca ²⁺ Exchange and K _ATP Potassium Channels by PIP ₂

1996 • 655 citations

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 • 569 citations

The plasma membrane

1983 • 561 citations

The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family

1989 • 535 citations

Purified (Ca2+-Mg2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids.

1981 • 467 citations

Calcineurin Inhibits VCX1-Dependent H⁺/Ca²+ Exchange and Induces Ca²+ ATPases in Saccharomyces cerevisiae

1996 • 431 citations

Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases

1994 • 430 citations

Purification of the (Ca2+-Mg2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column.

1979 • 426 citations

cDNA Cloning, functional expression, and mRNA Tissue Distribution of a Third Organellar Ca2+ Pump

1989 • 412 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 407 citations

Biogenesis: Plasma membrane calcium ATPase: 15 years of work on the purified enzyme ¹

1994 • 403 citations

Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.

1981 • 388 citations

The Ca2+ pump of the plasma membrane.

1992 • 382 citations

Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients

1989 • 374 citations

Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle.

1987 • 374 citations

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

1988 • 374 citations

Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger

1994 • 353 citations

Complete primary structure of a human plasma membrane Ca2+ pump.

1988 • 350 citations

Cloning of a Third Mammalian Na+-Ca2+ Exchanger, NCX3

1996 • 347 citations

[The calcium pump of the "relaxing granules" of muscle and its dependence on ATP-splitting].

1961 • 330 citations

Regulation and deregulation of cardiac Na+–Ca2+ exchange in giant excised sarcolemmal membrane patches

1990 • 320 citations

Initial localization of regulatory regions of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.

1993 • 290 citations

Structure of the calcium pump from sarcoplasmic reticulum at 8-Å resolution

1998 • 289 citations

Tissue Distribution of the Four Gene Products of the Plasma Membrane Ca2+ Pump

1995 • 289 citations

Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.

1991 • 277 citations

A novel Ca2+ pump expressed in brain, kidney, and stomach is encoded by an alternative transcript of the slow-twitch muscle sarcoplasmic reticulum Ca-ATPase gene. Identification of cDNAs encoding Ca2+ and other cation-transporting ATPases using an oligonucleotide probe derived from the ATP-binding site.

1988 • 268 citations

Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

1988 • 258 citations

Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms.

1994 • 246 citations

Ion motive ATPases. II. Energy coupling and work output

1987 • 237 citations

Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger.

1994 • 235 citations

Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane

1993 • 231 citations

The Regulation of the Na⁺ ‐Ca²⁺ Exchanger of Heart Sarcolemma

1983 • 211 citations

A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells.

1994 • 209 citations

The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.

1991 • 206 citations

Molecular Cloning of the Mammalian Smooth Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase

1989 • 204 citations

Primary structure and functional expression of the Na/Ca,K-exchanger from bovine rod photoreceptors.

1992 • 203 citations

The purified Ca2+ pump of human erythrocyte membranes catalyzes an electroneutral Ca2+-H+ exchange in reconstituted liposomal systems.

1982 • 199 citations

Identification of the high affinity Ca(2+)-binding domain of the cardiac Na(+)-Ca2+ exchanger.

1994 • 193 citations

Phosphorylation-dependent Regulation of Cardiac Na+/Ca2+ Exchanger via Protein Kinase C

1996 • 190 citations

Regulation of Ca2+-pumping ATPase of heart sarcolemma by a phosphorylation-dephosphorylation Process.

1981 • 186 citations

Na+-Ca2+ exchange in bovine rod outer segments requires and transports K+

1989 • 172 citations

The calmodulin‐binding site of the plasma membrane Ca²⁺ pump interacts with the transduction domain of the enzyme

1992 • 163 citations

Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

1990 • 161 citations

Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4.

1993 • 161 citations

Regulation of erythrocyte Ca2+ pump activity by protein kinase C.

1988 • 160 citations

ATP-dependent Regulation of Sodium-Calcium Exchange in Chinese Hamster Ovary Cells Transfected with the Bovine Cardiac Sodium-Calcium Exchanger

1995 • 160 citations

Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 160 citations

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

1993 • 155 citations

Ca2+ Transport in Saccharomyces Cerevisiae

1994 • 149 citations

Calcium pump isoforms: Diversity, selectivity and plasticity

1992 • 149 citations

Modulation of erythrocyte Ca2+-ATPase by selective calpain cleavage of the calmodulin-binding domain

1989 • 143 citations

The plasma membrane calcium pump: Functional domains, regulation of the activity, and tissue specificity of isoform expression

1994 • 141 citations

Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump

1989 • 138 citations

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane calcium pump

1990 • 137 citations

Molecular Cloning of a Novel Potassium-dependent Sodium-Calcium Exchanger from Rat Brain

1998 • 124 citations

Mapping of functional domains in the plasma membrane calcium pump using trypsin proteolysis

1990 • 119 citations

Identification of two domains which mediate the binding of activating phospholipids to the plasma‐membrane Ca²⁺ pump

1992 • 116 citations

Solubilization, purification, and reconstitution of the sodium-calcium exchanger from bovine retinal rod outer segments.

1988 • 113 citations

Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologs of the yeast secretory pathway calcium pump

1992 • 111 citations

The rat platelet 97-kDa Ca2+ATPase isoform is the sarcoendoplasmic reticulum Ca2+ATPase 3 protein.

1994 • 109 citations

Phosphorylation of the Ca2+-pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinase.

1985 • 109 citations

Regulation of Platelet Plasma Membrane Ca2+-ATPase by cAMP-dependent and Tyrosine Phosphorylation

1997 • 106 citations

Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes

1991 • 101 citations

A 31‐residue tryptic peptide from the active site of the [Ca⁺⁺]‐transporting adenosine triphosphatase of rabbit sarcoplasmic reticulum

1976 • 95 citations

Small-angle x-ray scattering study of calmodulin bound to two peptides corresponding to parts of the calmodulin-binding domain of the plasma membrane calcium pump

1991 • 95 citations

The significance of the isoforms of plasma membrane calcium ATPase

1998 • 93 citations

Cloning of two isoforms of the rat brain Na⁺Ca⁺ exchanger gene and their functional expression in HeLa cells

1993 • 87 citations

Growth Factor-induced Phosphorylation and Activation of Aortic Smooth Muscle Na+/Ca2+Exchanger

1995 • 85 citations

Protein Kinase C Activates the Plasma Membrane Ca2+ Pump Isoform 4b by Phosphorylation of an Inhibitory Region Downstream of the Calmodulin-binding Domain

1996 • 84 citations

The plasma membrane calcium pump: Recent developments and future perspectives

1996 • 83 citations

Ca2+/H+ countertransport and electrogenicity in proteoliposomes containing erythrocyte plasma membrane Ca-ATPase and exogenous lipids.

1994 • 82 citations

Biosynthesis and initial processing of the cardiac sarcolemmal Na+-Ca2+ exchanger

1993 • 81 citations

The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca(2+)-ATPases are on opposite sides of the membrane.

1992 • 80 citations

The ATP-binding site of the erythrocyte membrane Ca2+ pump. Amino acid sequence of the fluorescein isothiocyanate-reactive region.

1987 • 79 citations

Bacterial calcium transport

1987 • 78 citations

The epitope for monoclonal antibody A20 (amino acids 870-890) is located on the luminal surface of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 71 citations

Evidence for two isoforms of the endoplasmic-reticulum Ca2+ pump in pig smooth muscle

1989 • 69 citations

Amino acids Asn796 and Thr799 of the Ca(2+)-ATPase of sarcoplasmic reticulum bind Ca2+ at different sites.

1994 • 69 citations

Transmembranous organization of (Ca2(+)-Mg2+)-ATPase from sarcoplasmic reticulum. Evidence for lumenal location of residues 877-888.

1990 • 62 citations

Phosphorylation of the calmodulin binding domain of the plasma membrane Ca2+ pump by protein kinase C reduces its interaction with calmodulin and with its pump receptor site.

1994 • 62 citations

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

1992 • 60 citations

K(+)-dependent Na+/Ca2+ exchange in human platelets.

1993 • 59 citations

New Ca2+ pump isoforms generated by alternative splicing of rPMCA2 mRNA

1992 • 55 citations

Modulation of Endoplasmic Reticulum Calcium Pump Expression during T Lymphocyte Activation

1997 • 54 citations

Structure of the gene encoding the human plasma membrane calcium pump isoform 1.

1993 • 51 citations

The Organization of the Human Gene NCX1 Encoding the Sodium–Calcium Exchanger

1996 • 50 citations

The high affinity (Ca2+-Mg2+)-ATPase in liver plasma membranes is a Ca2+ pump. Reconstitution of the purified enzyme into phospholipid vesicles.

1987 • 46 citations

Expression and Functional Characterization of Isoforms 4 of the Plasma Membrane Calcium Pump

1996 • 43 citations

Effects of vanadate on MgATP stimulation of Na-Ca exchange support kinase-phosphatase modulation in squid axons

1994 • 41 citations

Molecular and cellular biology of plasma membrane calcium ATPase

1993 • 40 citations

Expression of the cardiac Na(+)-Ca2+ exchanger in insect cells using a baculovirus vector.

1992 • 40 citations

Mutation of Conserved Residues in Transmembrane Domains 4, 6, and 8 Causes Loss of Ca²⁺ Transport by the Plasma Membrane Ca²⁺ Pump

1996 • 35 citations

An Alternative Splicing Site Modifies the Carboxyl-terminal Trans-membrane Domains of the Na+/Ca2+ Exchanger

1995 • 33 citations

The sodium-calcium exchanger of bovine rod photoreceptors: K+-dependence of the purified and reconstituted protein

1991 • 33 citations

Synaptic vesicles and release of transmitters: new insights at the molecular level

1995 • 32 citations

Long‐Range Intramolecular Linked Functions in Activation and Inhibition of SERCA ATPases^a

1992 • 32 citations

The Putative Amino-terminal Signal Peptide of the Cloned Rat Brain Na+-Ca2+ Exchanger Gene (RBE-1) Is Not Mandatory for Functional Expression

1995 • 30 citations

Molecular Cloning of a P-type ATPase Gene from the Cyanobacterium Synechocystis sp. PCC 6803

1993 • 29 citations

The amino acid sequence of the phosphorylation domain of the erythrocyte Ca2+ ATPase

1987 • 29 citations

Purification and Characterization of the Ca2+-ATPase of Flavobacterium odoratum

1996 • 27 citations

Lysine 274 is essential for fructose 2,6-bisphosphate inhibition of fructose-1,6-bisphosphatase.

1992 • 26 citations

Conformational differences between the E1 and E2 states of the calcium adenosine triphosphatase of the erythrocyte plasma membrane as revealed by circular dichroism and fluorescence spectroscopy

1987 • 25 citations

A New Splicing Variant in the Frog Heart Sarcolemmal Na‐Ca Exchanger Creates a Putative ATP‐Binding Site^a

1996 • 25 citations

Expression of a Functionally Active Human Renal Sodium-Calcium Exchanger Lacking a Signal Sequence

1995 • 24 citations

Structure-function relationships in the Ca(2+)-ATPase of sarcoplasmic reticulum studied by use of the substrate analogue CrATP and site-directed mutagenesis. Comparison with the Na+,K(+)-ATPase.

1995 • 24 citations

Expression of two isoforms of the third sarco/endoplasmic reticulum Ca²⁺ATPase (SERCA3) in platelets. Possible recognition of the SERCA3b isoform by the PL/IM430 monoclonal antibody¹

1998 • 22 citations

Transport of K+ by Na(+)-Ca2+, K+ exchanger in isolated rods of lizard retina

1995 • 22 citations

A ouabain-insensitive, calcium-sensitive sodium efflux from giant axons of Loligo.

1967 • 19 citations

On the Mechanism of ATP‐Driven Ca²⁺ Transport by the Calcium ATPase of Sarcoplasmic Reticulum

1992 • 19 citations

Identification of a Novel Alternatively Spliced Isoform of the Na⁺‐Ca²⁺ Exchanger (NACA8) in Heart

1996 • 9 citations

Deleted Work

1955 • 0 citations