The plasma membrane calcium pump: Functional domains, regulation of the activity, and tissue specificity of isoform expression

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Ion motive ATPases. I. Ubiquity, properties, and significance to cell function

1987 • 964 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

Calcium pump of the plasma membrane

1991 • 659 citations

Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPase

1977 • 483 citations

ATP-dependent Ca++-Extrusion from human red cells

1966 • 445 citations

Purification of the (Ca2+-Mg2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column.

1979 • 426 citations

Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesterase

1977 • 395 citations

Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.

1981 • 388 citations

The Ca2+ pump of the plasma membrane.

1992 • 382 citations

Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.

1988 • 379 citations

Complete primary structure of a human plasma membrane Ca2+ pump.

1988 • 350 citations

Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

1988 • 258 citations

Molecular Cloning of a Third Isoform of the Calmodulin-sensitive Plasma Membrane Ca2+-Transporting ATPase That Is Expressed Predominantly in Brain and Skeletal Muscle

1989 • 221 citations

The Ca2+-pumping ATPase of plasma membranes purification, reconstitution and properties

1982 • 221 citations

The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.

1991 • 206 citations

MOLECULAR GENETICS OF MYOSIN

1987 • 187 citations

Regulation of Ca2+-pumping ATPase of heart sarcolemma by a phosphorylation-dephosphorylation Process.

1981 • 186 citations

A NEW ONE-STEP METHOD FOR THE HISTOCHEMISTRY AND CYTOCHEMISTRY OF CA<sup>2+</sup>-ATPASE ACTIVITY

1981 • 169 citations

The calmodulin‐binding site of the plasma membrane Ca²⁺ pump interacts with the transduction domain of the enzyme

1992 • 163 citations

Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane.

1990 • 161 citations

Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4.

1993 • 161 citations

Regulation of erythrocyte Ca2+ pump activity by protein kinase C.

1988 • 160 citations

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

1993 • 155 citations

Electrophoretic Separation of Different Phophosproteins Associated with Ca-ATPase and Na,K-ATPase in Human Red Cell Ghosts

1974 • 155 citations

Recent advances in the molecular characterization of plasma membrane Ca2+ pumps

1991 • 151 citations

A lipid requirement for the (Ca2+ + Mg2+)-activated ATPase of erythrocyte membranes

1977 • 149 citations

Modulation of erythrocyte Ca2+-ATPase by selective calpain cleavage of the calmodulin-binding domain

1989 • 143 citations

Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump

1989 • 138 citations

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane calcium pump

1990 • 137 citations

Activation of the erythrocyte Ca2+-ATPase by either self-association or interaction with calmodulin.

1988 • 135 citations

Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle

1984 • 129 citations

Controlled proteolysis of the purified Ca2+-ATPase of the erythrocyte membrane. A correlation between the structure and the function of the enzyme.

1984 • 125 citations

The maximal velocity and the calcium affinity of the red cell calcium pump may be regulated independently.

1987 • 124 citations

Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.

1992 • 121 citations

Mapping of functional domains in the plasma membrane calcium pump using trypsin proteolysis

1990 • 119 citations

Plasma membrane Ca2+-ATPase isoforms: distribution of mRNAs in rat brain by in situ hybridization

1992 • 117 citations

Identification of two domains which mediate the binding of activating phospholipids to the plasma‐membrane Ca²⁺ pump

1992 • 116 citations

The calmodulin-binding domain mediates the self-association of the plasma membrane Ca2+ pump.

1991 • 113 citations

mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon.

1989 • 107 citations

Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes

1991 • 101 citations

Modulation of human erythrocyte Ca2+Mg2+ ATPase activity by phospholipase A2 and proteases. A comparison with calmodulin

1980 • 100 citations

PLASMA MEMBRANE Ca²⁺‐PUMPING ATPases*

1982 • 91 citations

Molecular properties of the red cell calcium pump

1980 • 87 citations

Activation of the Ca2+-ATPase of human erythrocyte membrane by an endogenous Ca2+-dependent neutral protease

1988 • 81 citations

The ATP-binding site of the erythrocyte membrane Ca2+ pump. Amino acid sequence of the fluorescein isothiocyanate-reactive region.

1987 • 79 citations

Regulatory interaction between calmodulin and ATP on the red cell Ca2+ pump

1980 • 77 citations

Localization of two genes encoding plasma membrane Ca2+-transporting ATPases to human chromosomes 1q25–32 and 12q21–23

1991 • 75 citations

Calmodulin-binding domains from isozymes of the plasma membrane Ca2+ pump have different regulatory properties

1991 • 70 citations

Expression of Plasma Membrane Calcium‐Pumping ATPase mRNAs in Developing Rat Brain and Adult Brain Subregions: Evidence for Stage‐Specific Expression

1992 • 69 citations

The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte

1994 • 64 citations

von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.

1993 • 63 citations

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

1992 • 60 citations

The C-terminal domain of the plasma membrane Ca2+ pump contains three high affinity Ca2+ binding sites

1993 • 59 citations

Ca++-ATPase in the central nervous system: an EM cytochemical study.

1989 • 56 citations

Structure of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and characterization of alternative splicing and transcription products. Skeletal muscle-specific splicing results in a plasma membrane Ca(2+)-ATPase with a novel calmodulin-binding domain.

1992 • 56 citations

New Ca2+ pump isoforms generated by alternative splicing of rPMCA2 mRNA

1992 • 55 citations

Purification of the Ca2+-and Mg2+-requiring ATPase from rat brain synaptic plasma membrane

1982 • 52 citations

Structure of the gene encoding the human plasma membrane calcium pump isoform 1.

1993 • 51 citations

Cerebrospinal fluid calcium homeostasis: evidence for a plasma membrane Ca2+-pump in mammalian choroid plexus

1989 • 50 citations

Characterization of Calcium‐Activated and Magnesium‐Activated ATPases of Brain Nerve Endings

1984 • 49 citations

Photochemical cross-linking of azidocalmodulin to the (Ca2+ + Mg2+)-ATPase of the erythrocyte membrane.

1981 • 48 citations

Identification of a Ca2+-ATPase in cerebellar Purkinje cells

1989 • 47 citations

Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane calcium pump

1992 • 42 citations

Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 Gene Encoding Human Ca2+-Pumping ATPase Isoform PMCA2

1992 • 37 citations

Molecular properties of the red cell calcium pump

1980 • 37 citations

Pre-steady-state phosphorylation of the human red cell Ca2+-ATPase.

1988 • 34 citations

Activation of erythrocyte membrane Ca2+-ATPase by calpain

1987 • 33 citations

Calmodulin and the target size of the (Ca2+ + Mg2+)-ATPase of human red-cell ghosts

1984 • 31 citations

Characteristics of Mg2+-dependent, ATP-activated Ca2+ transport in synaptic and microsomal membranes and in permeabilized synaptosomes.

1987 • 31 citations

The amino acid sequence of the phosphorylation domain of the erythrocyte Ca2+ ATPase

1987 • 29 citations

Guanine nucleotide-, and inositol trisphosphate-induced inhibition of the CA2+ pump in rat heart sarcolemmal vesicles

1988 • 28 citations

Calcium ATPase Activities in Synaptic Plasma Membranes of Seizure‐Prone Mice

1986 • 27 citations

The molecular weight of the calcium-transport-ATPase of the human red blood cell determined by radiation inactivation

1983 • 27 citations

Cytochemical localization of Ca2+-ATPase activity in peripheral nerve

1988 • 27 citations

Lysine 274 is essential for fructose 2,6-bisphosphate inhibition of fructose-1,6-bisphosphatase.

1992 • 26 citations

Role of the phospholipid environment in modulating the activity of the rat brain synaptic plasma membrane calcium ATPase

1990 • 20 citations

The effect of calmodulin on the phosphoprotein intermediate of Mg2+-dependent Ca2+-stimulated adenosine triphosphatase in human erythrocyte membranes

1981 • 17 citations