Granulocyte colony-stimulating factor versus placebo in addition to penicillin G in a randomized blinded study of gram-negative pneumonia sepsis: analysis of survival and multisystem organ failure

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

1991 • 1,401 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

1988 • 961 citations

Pneumococcal Bacteremia with Especial Reference to Bacteremic Pneumococcal Pneumonia

1964 • 947 citations

Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

1990 • 765 citations

EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTOTOXIC CHEMOTHERAPY

1988 • 740 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer

1987 • 605 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Variations in Mortality and Length of Stay in Intensive Care Units

1993 • 551 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

Pathogenesis of Disseminated Intravascular Coagulation in Sepsis

1993 • 349 citations

Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

1989 • 277 citations

Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha.

1992 • 251 citations

In vivo stimulation of granulopoiesis by recombinant human granulocyte colony-stimulating factor.

1987 • 231 citations

Cytokines, sepsis and immunomodulation

1993 • 219 citations

Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: phase I toxicity and effects on lipid metabolism.

1988 • 217 citations

Clinical pharmacology of recombinant human tumor necrosis factor in patients with advanced cancer.

1987 • 216 citations

Recombinant human TNF alpha stimulates production of granulocyte colony- stimulating factor

1987 • 212 citations

Biological Effects of Bacterial Endotoxins in Man

1973 • 208 citations

Recombinant human granulocyte colony-stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor- mediated agonists and stimulation of C3bi receptor expression and adherence

1989 • 199 citations

Treatment of chemotherapy-induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and duration of therapy.

1989 • 181 citations

Chemotactic activity of recombinant human granulocyte colony- stimulating factor

1988 • 165 citations

Recombinant human granulocyte colony-stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia

1987 • 152 citations

Serum tumor necrosis factor levels in patients with infectious disease and septic shock.

1990 • 128 citations

Interleukin-1, tumor necrosis factor, and the production of colony- stimulating factors by cultured mesenchymal cells

1988 • 125 citations

The cell in shock: the origin of multiple organ failure

1991 • 120 citations

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

1988 • 105 citations

Granulocyte Colony-stimulating Factor Does Not Enhance Endotoxin-induced Acute Lung Injury in Guinea Pigs

1992 • 100 citations

Granulocyte colony-stimulating factor prophylaxis before operation protects against lethal consequences of postoperative peritonitis.

1994 • 95 citations

Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support

1993 • 94 citations

TREATMENT OF INTRA-ABDOMINAL INFECTION WITH GRANULOCYTE COLONY-STIMULATING FACTOR

1992 • 93 citations

Effect of granulocyte colony-stimulating factor on acute lung injury in the rat.

1995 • 76 citations

TNF but not IL-1 in dogs causes lethal lung injury and multiple organ dysfunction similar to human sepsis

1991 • 75 citations

Effect of granulocyte colony-stimulating factor on neutropenia due to chemotherapy for non-Hodgkin's lymphoma

1990 • 66 citations

The beneficial effect of granulocyte colony-stimulating factor (G-CSF) in combination with gentamicin on survival after Pseudomonas burn wound infection.

1989 • 66 citations

EFFECT OF GRANULOCYTE COLONY-STIMULATING FACTOR ON SYSTEMIC AND PULMONARY RESPONSES TO ENDOTOXIN IN PIGS

1993 • 60 citations

Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model

1993 • 46 citations

Impairment in Gas Exchange After Granulocyte Colony Stimulating Factor (G-CSF) in a Patient With the Adult Respiratory Distress Syndrome

1995 • 44 citations

Effects of granulocyte colony-stimulating factor in modifying mortality from Pseudomonas aeruginosa pneumonia after hemorrhage

1992 • 41 citations

The High Cost of Acute Health Care: A Review of Escalating Costs and Limitations of Such Exposure in Intensive Care Units

1987 • 30 citations

Effect of combination therapy with recombinant human granulocyte colony-stimulating factor (rG-CSF) and antibiotics in nentropenic mice unresponsive to antibiotics alone

1991 • 29 citations

Leucocytosis induced in rabbits by intravenous or central injection of granulocyte colony stimulating factor.

1990 • 19 citations

Granulocyte colony-stimulating factor (G-CSF) treatment in a neutropenic leukemia patient with diffuse interstitial pulmonary infiltrates

1991 • 16 citations