The insulin receptor: structural features

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980 • 388 citations

Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction.

1975 • 226 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Purification and properties of insulin receptors from rat liver membranes

1977 • 188 citations

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.

1980 • 187 citations

The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.

1976 • 185 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Insulin Action and the Regulation of Hexose Transport

1980 • 170 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit.

1980 • 144 citations

Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues.

1981 • 124 citations

Proteolytic nicking of the acetylcholine receptor

1980 • 90 citations

Hormone Binding Alters the Conformation of the Insulin Receptor

1980 • 70 citations

Functional relationships between insulin binding, action, and degradation. A reassessment.

1980 • 68 citations

Insulin action

1981 • 67 citations

Subunit structure of the insulin receptor of the human lymphocyte

1980 • 61 citations

Multiple Redox Forms of the Insulin Receptor in Native Liver Membranes

1980 • 58 citations

The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate

1979 • 55 citations

Photoaffinity labeling of insulin receptor with an insulin analog selectively modified at the amino terminal of the B chain

1980 • 50 citations

Purification of the adipocyte insulin receptor by immunoaffinity chromatography.

1980 • 49 citations

Digestion of insulin receptors with proteolytic and glycosidic enzymes-effects on purified and membrane-associated receptor subunits

1980 • 46 citations

Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation.

1981 • 41 citations

Studies on the mechanism of insulin action: Basic concepts and clinical implications

1977 • 39 citations

What is the molecular basis for the action of insulin?

1979 • 36 citations

Insulin-related growth factors

1978 • 30 citations

Multiple redox forms of the insulin receptor in native liver membranes

1980 • 13 citations