Potential sources of increased iron in the substantia nigra of parkinsonian patients
Data up to Jan 2025
Total Citations Per Year
Abstract
References (74)
Iron, brain ageing and neurodegenerative disorders
2004 • 1,737 citations
Handbook of experimental pharmacology
1984 • 1,599 citations
THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN
1958 • 1,401 citations
Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains
1989 • 1,367 citations
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
1988 • 1,235 citations
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
1988 • 738 citations
Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?
1994 • 701 citations
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
2005 • 681 citations
Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2·8 Å resolution
1989 • 588 citations
Iron Homeostasis, Oxidative Stress, and DNA Damage
1997 • 557 citations
Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains
1991 • 516 citations
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
1990 • 457 citations
Brain iron and ferritin in Parkinson's and Alzheimer's diseases
1990 • 440 citations
Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study
1992 • 423 citations
Iron metabolism
1999 • 408 citations
Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.
1984 • 392 citations
Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease
1992 • 367 citations
Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier
1999 • 365 citations
Brain iron pathways and their relevance to Parkinson's disease
2001 • 356 citations
Lactoferrin and transferrin: A comparative study
1972 • 335 citations
Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease
2005 • 334 citations
The Relevance of Iron in the Pathogenesis of Parkinson's Disease
2004 • 331 citations
A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains
1995 • 320 citations
Iron‐Melanin Complex in Substantia Nigra of Parkinsonian Brains: An X‐Ray Microanalysis
1992 • 308 citations
The possible role of iron in the etiopathology of parkinson's disease
1993 • 303 citations
Nitric oxide mediates iron release from ferritin
1990 • 290 citations
Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?
1989 • 290 citations
Heme oxygenase-1: role in brain aging and neurodegeneration
2000 • 268 citations
Cellular iron metabolism
1999 • 263 citations
Decreased Ferritin Levels in Brain in Parkinson's Disease
1990 • 254 citations
Iron and free radical reactions: two aspects of antioxidant protection
1986 • 249 citations
Complex I, Iron, and ferritin in Parkinson's disease substantia nigra
1994 • 239 citations
Heme oxygenase expression in human central nervous system disorders
2004 • 232 citations
Dopamine, 6-hydroxydopamine, iron, and dioxygen — their mutual interactions and possible implication in the development of Parkinson's disease
1996 • 232 citations
Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation
1999 • 228 citations
The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls
1993 • 219 citations
Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease.
1995 • 209 citations
Interaction of neuromelanin and iron in substantia nigra and other areas of human brain
1996 • 192 citations
Isoforms of ferritin have a specific cellular distribution in the brain
1994 • 175 citations
Iron-binding characteristics of neuromelanin of the human substantia nigra
2003 • 174 citations
Abnormal localization of iron regulatory protein in Alzheimer's disease
1998 • 170 citations
Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study
1994 • 154 citations
In Vitro Studies of Ferritin Iron Release and Neurotoxicity
1998 • 152 citations
The role of transition metals in the pathogenesis of Parkinson's disease
1995 • 135 citations
Binding of Iron to Neuromelanin of Human Substantia Nigra and Synthetic Melanin: An Electron Paramagnetic Resonance Spectroscopy Study
1997 • 127 citations
Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease.
1995 • 121 citations
6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation
1989 • 121 citations
Altered systemic iron metabolism in Parkinson's disease
1997 • 120 citations
Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases
1996 • 119 citations
Neurodegenerative disease and iron storage in the brain
2004 • 117 citations
Total and paramagnetic metals in human substantia nigra and its neuromelanin
1993 • 115 citations
Mössbauer Spectroscopic Studies of Purified Human Neuromelanin Isolated from the Substantia Nigra
1995 • 113 citations
Copper, Ceruloplasmin, Superoxide Dismutase and Iron Parameters in Parkinson's Disease
1999 • 112 citations
Impaired iron homeostasis in Parkinson’s disease
2000 • 98 citations
An autoradiographic study of the uptake and distribution of iron by the brain of the young rat
1990 • 98 citations
Generation of the Neurotoxin 6-Hydroxydopamine by Peroxidase/H2O2 Oxidation of Dopamine
1995 • 94 citations
Parkinson's disease: a major hypokinetic basal ganglia disorder
1999 • 87 citations
Activated microglia cause superoxide-mediated release of iron from ferritin
1995 • 85 citations
Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn
1989 • 76 citations
Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys
2003 • 61 citations
Pathology of Parkinson’s Syndrome
1989 • 59 citations
Biochemical fundamentals of Parkinson's disease.
1988 • 58 citations
Reductive release of ferritin iron: A kinetic assay
1988 • 57 citations
Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment
1999 • 53 citations
Transferrin receptors in the Parkinsonian midbrain
1994 • 51 citations
The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease
1997 • 47 citations
The interaction of lactoferrin with human monocytes.
1991 • 44 citations
Lactoferrin binding by leukemia cell lines
1987 • 40 citations
Neurodegenerative diseases and metal ions
2006 • 40 citations
Demonstration and Characterization of the Iron Regulatory Protein in Human Brain
1996 • 35 citations
Dopaminforschung heute und morgen — L-Dopa in der Zukunft
1985 • 28 citations
Views on neurodegeneration as a basis for neuroprotective strategies.
2004 • 14 citations
L-Dopa-Substitution der Parkinson-Krankheit
1985 • 13 citations
Captopril Induces Iron Release From Ferritin and Oxidative Stress
1995 • 7 citations