Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Drug Metabolism and Disposition

2014 • 2,466 citations

Ground states of molecules. XXV. MINDO/3. Improved version of the MINDO semiempirical SCF-MO method

1975 • 1,642 citations

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Studies on plant amylases

1932 • 727 citations

Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

1985 • 653 citations

The O-Dealkylation of 7-Ethoxycoumarin by Liver Microsomes. A Direct Fluorometric Test

1972 • 634 citations

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.

1983 • 436 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1972 • 350 citations

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1982 • 265 citations

Mode of action of antifungal agents

1984 • 221 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1973 • 208 citations

The crystal structure of imidazole at –150°C

1966 • 196 citations

Nature of the type I and II spectral changes in liver microsomes

1970 • 172 citations

Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates

1975 • 151 citations

Imidazole antimycotics: Inhibitors of steroid aromatase

1985 • 137 citations

Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver.

1984 • 123 citations

Molecular dimensions of the substrate binding site of cytochrome P-448

1986 • 111 citations

Steric factors in the inhibitory interaction of imidazoles with microsomal enzymes

1977 • 108 citations

Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents

1986 • 107 citations

Cytochrome P-448 and the activation of toxic chemicals and carcinogens

1984 • 98 citations

Determination of cytochrome P-448 activity in biological tissues

1984 • 95 citations

In VitroInhibition of Testosterone Biosynthesis by Ketoconazole

1985 • 91 citations

Effects of sterol biosynthesis-inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi

1984 • 89 citations

The interaction of representative members from two classes of antimycotics—the azoles and the allylamines—with cytochromes P-450 in steroidogenic tissues and liver

1985 • 87 citations

Cytochrome P450 gene expression and regulation

1985 • 85 citations

The effect of ketoconazole on hepatic oxidative drug metabolism in the rat in vivo and in vitro.

1985 • 85 citations

Mouse liver testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha). Purification, regioselectivity, stereospecificity, and sex-dependent expression.

1984 • 71 citations

Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole.

1981 • 53 citations

Clotrimazole as an inhibitor of benzo[a]pyrene metabolite-DNA adduct formation in vitro and of microsomal mono-oxygenase activity.

1980 • 49 citations

Studies on the substrate-binding sites of liver microsomal cytochrome P-448

1982 • 39 citations

A refinement of the crystal structure of tetraphenylmethane: three independent redeterminations

1975 • 36 citations

cis-1-Acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1-imidazolylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine: ketoconazole. A crystal structure with disorder

1979 • 34 citations

Insights into the active site of the cytochrome P-450 haemoprotein family-a unifying concept based on structural considerations

1982 • 33 citations

Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation

1983 • 31 citations

The Crystal Structure of 1‐{2,4‐Dichloro‐β‐ [(2,4‐Dichloro‐Benzyl)Oxy] Phenethyl} Imidazole Hemihydrate: Miconazole. 1/2 H₂O

1979 • 27 citations

Substrate-elicited dissociation of a complex of cytochrome P-450 with a methylenedioxyphenyl metabolite

1976 • 23 citations

Ligand-complex formation between cytochromes P-450 and P-448 and methylenedioxyphenyl compounds

1985 • 19 citations

Induction, modification and inhibition of rat liver microsomal benzo(a)pyrene hydroxylase; Correlation with the S-9-mediated mutagenicity of benzo(a)pyrene

1978 • 15 citations