Thrombolysis in Acute Myocardial Infarction

An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction

1993 • 3,911 citations

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

1985 • 2,003 citations

A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial Infarction

1993 • 1,980 citations

Comparison of Invasive and Conservative Strategies after Treatment with Intravenous Tissue Plasminogen Activator in Acute Myocardial Infarction

1989 • 991 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction

1992 • 866 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

In-hospital mortality and clinical course of 20 891 patients with suspected acute myocardial infarction randomised between alteplase and streptokinase with or without heparin

1990 • 612 citations

Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease

1981 • 597 citations

Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials

1985 • 578 citations

Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications.

1989 • 461 citations

A Comparison between Heparin and Low-Dose Aspirin as Adjunctive Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction

1990 • 430 citations

Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation.

1988 • 394 citations

Guidelines for the early management of patients with acute myocardial infarction

1990 • 324 citations

Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial.

1992 • 301 citations

Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction

1990 • 270 citations

Optimal utilization of thrombolytic therapy for acute myocardial infarction: Concepts and controversies

1990 • 212 citations

Selection of Patients with Acute Myocardial Infarction for Thrombolytic Therapy

1990 • 203 citations

Outcome of Patients with Acute Myocardial Infarction Who Are Ineligible for Thrombolytic Therapy

1991 • 197 citations

Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: A meta-analysis

1992 • 187 citations

Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo.

1989 • 171 citations

Relative efficacy of antithrombin compared with antiplatelet agents in accelerating coronary thrombolysis and preventing early reocclusion.

1991 • 152 citations

Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits

1993 • 129 citations

Clinical risks of thrombolytic therapy

1992 • 119 citations

Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator. Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. The TAMI Study Group.

1989 • 117 citations

Rhabdomyolysis in the hyperosmolal state

1990 • 114 citations

Correlation between level of heparinization and patency of the infarct-related coronary artery after treatment of acute myocardial infarction with alteplase (rt-PA)

1992 • 107 citations

Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis.

1988 • 89 citations

Simultaneous administration of thromboxane A2- and serotonin S2-receptor antagonists markedly enhances thrombolysis and prevents or delays reocclusion after tissue-type plasminogen activator in a canine model of coronary thrombosis.

1989 • 87 citations

Patency of the infarct-related artery and left ventricular function as the major determinants of survival after Q-wave acute myocardial infarction

1993 • 87 citations

In vivo thrombin inhibition enhances and sustains arterial recanalization with recombinant tissue-type plasminogen activator.

1990 • 81 citations

Heparin-induced prolongation of partial thromboplastin time after thrombolysis: Relation to coronary artery patency

1992 • 76 citations

Thrombolysis in unstable angina. Randomized double-blind trial of t-PA and placebo.

1992 • 75 citations

Platelet-dependent thrombin generation after in vitro fibrinolytic treatment.

1992 • 63 citations

Ischemic stroke and intracranial hemorrhage following thrombolytic therapy for acute myocardial infarction: A risk-benefit analysis

1992 • 62 citations

Direct evidence for a basolateral membrane Cl- conductance in toad retinal pigment epithelium

1992 • 51 citations

Direct Angioplasty for Acute Myocardial Infarction

1992 • 50 citations

Improved survival up to four years after early coronary thrombolysis

1988 • 49 citations

Combination of inhibition of thrombin and blockade of thromboxane A2 synthetase and receptors enhances thrombolysis and delays reocclusion in canine coronary arteries.

1992 • 47 citations

Hemodynamic correlates of the third heart sound during the evolution of chronic heart failure

1993 • 45 citations

Inhibitors of the platelet glycoprotein IIb/IIIa receptor as conjunctive therapy for coronary artery thromboiysis

1992 • 42 citations

Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine model of coronary thrombosis.

1990 • 37 citations

Highly variable anticoagulant response after subcutaneous administration of high-dose (12,500 IU) heparin in patients with myocardial infarction and healthy volunteers.

1992 • 36 citations

Effect of thrombin inhibition on the dynamics of thrombolysis and on platelet function during thrombolytic therapy.

1992 • 31 citations

Thrombolysis and myocardial infarction

1991 • 25 citations

Coronary thrombolysis for the elderly?

1991 • 22 citations

Proportionate mortality trends: 1950 through 1986

1990 • 9 citations

Late thrombolytic therapy

1993 • 7 citations