A constitutively active mutant of the α1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins Gqα and G11α than the wild-type receptor

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Subtypes of α ₁ ‐ and α ₂ ‐adrenergic receptors

1992 • 358 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

δ-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2

1990 • 252 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

1992 • 205 citations

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

1992 • 157 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Expanding horizons for receptors coupled to G proteins: diversity and disease

1994 • 127 citations

Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications

1993 • 116 citations

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.

1992 • 84 citations

The gonadotrophin-releasing hormone receptor of alpha T3-1 pituitary cells regulates cellular levels of both of the phosphoinositidase C-linked G proteins, Gq alpha and G11 alpha, equally.

1994 • 75 citations

Widespread distribution of Gqα/Gllα detected immunologically by an antipeptide antiserum directed against the predicted C‐terminal decapeptide

1991 • 65 citations

Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq α/G11 α following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

1993 • 60 citations

Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma x glioma hybrid NG108-15 cells transfected to express differing levels of the human beta 2-adrenoceptor.

1995 • 55 citations

Why are there so many adrenoceptor subtypes?

1994 • 50 citations

Regulation of basal adenylate cyclase activity in neuroblastoma × glioma hybrid, NG108-15, cells transfected to express the human β 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade

1994 • 47 citations

Gonadotrophin-releasing hormone receptor agonist-mediated down-regulation of Gq alpha/G11 alpha (pertussis toxin-insensitive) G proteins in alpha T3-1 gonadotroph cells reflects increased G protein turnover but not alterations in mRNA levels.

1995 • 43 citations

Degradation of G11α/Gqα Is Accelerated by Agonist Occupancy of α1A/D, α1B, and α1C Adrenergic Receptors

1995 • 40 citations

Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein

1990 • 39 citations

Agonist regulation of cellular Gs α-subunit levels in neuroblastoma × glioma hybrid NG108-15 cells transfected to express different levels of the human β 2 adrenoceptor

1994 • 34 citations

Down-regulation of the G-proteins Gqα and G11α by transfected human M3 muscarinic acetylcholine receptors in Chinese hamster ovary cells is independent of receptor down-regulation

1995 • 20 citations

Hereditary and acquired defects in signaling through the hormone-receptor-G protein complex

1994 • 20 citations

Expression of the Human β2‐Adrenoceptor in NCB20 Cells Results in Agonist Activation of Adenylyl Cyclase and Agonist‐Mediated Selective Down‐Regulation of G_sα

1995 • 17 citations

Signalling and regulation of the α1B-adrenergic receptor

1995 • 12 citations