Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega

2011 • 14,101 citations

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2012 • 5,709 citations

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2004 • 3,745 citations

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2005 • 3,059 citations

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2003 • 2,536 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

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2005 • 1,761 citations

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

2015 • 1,520 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

Commentary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

2013 • 1,218 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

2012 • 936 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

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2015 • 873 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

A structural analysis of M protein in coronavirus assembly and morphology

2010 • 822 citations

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

2015 • 614 citations

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

2003 • 524 citations

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

2009 • 489 citations

Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012

2012 • 477 citations

Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

2016 • 460 citations

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

2013 • 420 citations

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

2012 • 417 citations

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

2006 • 411 citations

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

2013 • 389 citations

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

2014 • 377 citations

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists

2013 • 274 citations

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

2009 • 265 citations

Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

2001 • 261 citations

Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?

2014 • 241 citations

Modulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK

2007 • 212 citations

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

2015 • 203 citations

Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

2013 • 201 citations

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

2014 • 182 citations

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

2014 • 181 citations

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

2013 • 172 citations

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

2011 • 163 citations

Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus

2013 • 160 citations

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

2013 • 159 citations

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

2004 • 157 citations

First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013

2013 • 152 citations

TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales

2001 • 138 citations

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

2015 • 129 citations

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

2013 • 122 citations

Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control

2015 • 121 citations

First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities - May 2014.

2014 • 113 citations

To sense or not to sense viral RNA—essentials of coronavirus innate immune evasion

2014 • 109 citations

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

2014 • 108 citations

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

2014 • 106 citations

Spread of MERS to South Korea and China

2015 • 91 citations

Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread

2013 • 88 citations

First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities—May 2014

2014 • 66 citations

Investigation of an imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Florence, Italy, May to June 2013

2013 • 64 citations

A molecular arms race between host innate antiviral response and emerging human coronaviruses

2016 • 61 citations

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

2015 • 58 citations

Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein

2013 • 52 citations

Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity

2012 • 51 citations

Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1

2014 • 46 citations

IKK-i signals through IRF3 and NFκB to mediate the production of inflammatory cytokines

2005 • 45 citations

MIP-T3 Is a Negative Regulator of Innate Type I IFN Response

2011 • 44 citations

Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

2014 • 42 citations

A case of imported Middle East Respiratory Syndrome coronavirus infection and public health response, Greece, April 2014

2014 • 38 citations

Severe Respiratory Illness Associated With a Novel Coronavirus — Saudi Arabia and Qatar, 2012

2012 • 24 citations

Deleted Work

1955 • 0 citations