The Acute Respiratory Distress Syndrome

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

1994 • 6,682 citations

ACUTE RESPIRATORY DISTRESS IN ADULTS

1967 • 4,096 citations

An Expanded Definition of the Adult Respiratory Distress Syndrome

1988 • 2,636 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

High Inflation Pressure Pulmonary Edema: Respective Effects of High Airway Pressure, High Tidal Volume, and Positive End-expiratory Pressure

1988 • 1,647 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study

1979 • 1,251 citations

Prognosis in Acute Organ-System Failure

1985 • 1,248 citations

Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay

1993 • 1,206 citations

Septic Shock in Humans

1990 • 1,170 citations

Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome.

1994 • 948 citations

Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome

1990 • 899 citations

High-Dose Corticosteroids in Patients with the Adult Respiratory Distress Syndrome

1987 • 881 citations

Nosocomial Pneumonia in Patients Receiving Continuous Mechanical Ventilation: Prospective Analysis of 52 Episodes with Use of a Protected Specimen Brush and Quantitative Culture Techniques

1989 • 832 citations

Adult Respiratory Distress Syndrome: Risk with Common Predispositions

1983 • 810 citations

The Effects of High-Dose Corticosteroids in Patients with Septic Shock

1984 • 761 citations

Clinical predictors of the adult respiratory distress syndrome

1982 • 684 citations

State of the Art

1983 • 655 citations

Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome

1983 • 654 citations

Relationships Between Lung Computed Tomographic Density, Gas Exchange, and PEEP in Acute Respiratory Failure

1988 • 640 citations

Intact Epithelial Barrier Function Is Critical for the Resolution of Alveolar Edema in Humans

1990 • 588 citations

Improved Outcome Based on Fluid Management in Critically III Patients Requiring Pulmonary Artery Catheterization

1992 • 578 citations

Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock

1992 • 555 citations

Adult Respiratory-Distress Syndrome

1982 • 554 citations

Surfactant and the Adult Respiratory Distress Syndrome

1993 • 554 citations

Ineffectiveness of High-dose Methylprednisolone in Preventing Parenchymal Lung Injury and Improving Mortality in Patients with Septic Shock

1988 • 511 citations

Impact of Previous Antimicrobial Therapy on the Etiology and Outcome of Ventilator-associated Pneumonia

1993 • 495 citations

Persistent Paralysis in Critically Ill Patients after Long-Term Administration of Vecuronium

1992 • 487 citations

Diagnosis of Nosocomial Bacterial Pneumonia in Acute, Diffuse Lung Injury

1981 • 484 citations

Inhaled Nitric Oxide Selectively Reverses Human Hypoxic Pulmonary Vasoconstriction without Causing Systemic Vasodilation

1993 • 459 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Role of Oxygen Debt in the Development of Organ Failure Sepsis, and Death in High-Risk Surgical Patients

1992 • 426 citations

Use of extreme position changes in acute respiratory failure

1976 • 423 citations

Chest wall restriction limits high airway pressure-induced lung injury in young rabbits

1989 • 422 citations

Acute Eosinophilic Pneumonia as a Reversible Cause of Noninfectious Respiratory Failure

1989 • 414 citations

The Prone Position in ARDS Patients

1988 • 377 citations

Early Methylprednisolone Treatment for Septic Syndrome and the Adult Respiratory Distress Syndrome

1987 • 366 citations

Complications of Acute Respiratory Failure

1988 • 357 citations

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man

1994 • 322 citations

Histopathologic Pulmonary Changes from Mechanical Ventilation at High Peak Airway Pressures

1991 • 317 citations

Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy.

1994 • 312 citations

Fibroproliferative Phase of ARDS

1991 • 302 citations

The Standardization of Bronchoscopic Techniques for Ventilator-Associated Pneumonia

1992 • 296 citations

Adult respiratory distress syndrome profiles by computed tomography

1986 • 294 citations

Myopathy in Severe Asthma

1992 • 291 citations

A Multicenter Registry of Patients with Acute Respiratory Distress Syndrome: Physiology and Outcome

1992 • 291 citations

Improved Survival in ARDS Patients Associated with a Reduction in Pulmonary Capillary Wedge Pressure

1990 • 289 citations

The value of edema fluid protein measurement in patients with pulmonary edema

1979 • 282 citations

Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans

1993 • 280 citations

ARDS: clinical lessons from the oleic acid model of acute lung injury.

1994 • 279 citations

Randomized Double-Blind, Multicenter Study of Prostaglandin E1 in Patients with the Adult Respiratory Distress Syndrome

1989 • 279 citations

Early Application of Positive End-Expiratory Pressure in Patients at Risk for the Adult Respiratory-Distress Syndrome

1984 • 276 citations

The radiologic distinction of cardiogenic and noncardiogenic edema

1985 • 270 citations

Fluid Balance and the Adult Respiratory Distress Syndrome^1–3

1987 • 269 citations

Incidence of pulmonary barotrauma in a medical ICU

1983 • 253 citations

Pulmonary Pathology of the Adult Respiratory Distress Syndrome

1990 • 247 citations

Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome

1992 • 247 citations

The Adult Respiratory Distress Syndrome

1992 • 245 citations

Pressure Controlled Inverse Ratio Ventilation in Severe Adult Respiratory Failure

1988 • 243 citations

Prostaglandin E1 and Survival in Patients with the Adult Respiratory Distress Syndrome

1986 • 221 citations

Pulmonary Barotrauma in Mechanical Ventilation

1992 • 221 citations

Fluid Balance during Pulmonary Edema

1991 • 219 citations

Pulmonary barotrauma during mechanical ventilation

1973 • 210 citations

External Work Output and Force Generation during Synchronized Intermittent Mechanical Ventilation: Effect of Machine Assistance on Breathing Effort

1988 • 208 citations

Inverse Ratio Ventilation in ARDS

1991 • 200 citations

A Prospective Study of Lung Water Measurements during Patient Management in an Intensive Care Unit

1987 • 198 citations

Lung Edema Caused by High Peak Inspiratory Pressures in Dogs: Role of Increased Microvascular Filtration Pressure and Permeability

1990 • 193 citations

The Role of Selective Digestive Tract Decontamination on Mortality and Respiratory Tract Infections

1994 • 188 citations

Neuromuscular Blockade in the Intensive Care Unit: More than We Bargained for

1993 • 183 citations

Effect of ibuprofen in patients with severe sepsis

1991 • 180 citations

Acute Myopathy during Treatment of Status Asthmaticus with Corticosteroids and Steroidal Muscle Relaxants

1992 • 179 citations

Crack Lung: An Acute Pulmonary Syndrome with a Spectrum of Clinical and Histopathologic Findings

1990 • 163 citations

Ventilator-associated pneumonia. A multivariate analysis

1993 • 161 citations

Safety of Bronchoalveolar Lavage in Patients with Adult Respiratory Distress Syndrome

1993 • 161 citations

Idiopathic Pulmonary Fibrosis in Adult Respiratory Distress Syndrome

1985 • 160 citations

An Early Test of Survival in Patients with the Adult Respiratory Distress Syndrome

1989 • 160 citations

Dissociation between plasma and monocyte‐associated cytokines during sepsis

1991 • 158 citations

A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome

1993 • 155 citations

Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients.

1988 • 155 citations

High-Frequency Jet Ventilation

2022 • 150 citations

Improved Oxygenation and Lower Peak Airway Pressure in Severe Adult Respiratory Distress Syndrome

1986 • 149 citations

Pressure Control Inverse Ratio Ventilation as a Method to Reduce Peak Inspiratory Pressure and Provide Adequate Ventilation and Oxygenation

1989 • 149 citations

Prostacyclin and Thromboxane A₂Formation Is Increased in Human Sepsis Syndrome: Effects of Cyclooxygenase Inhibition

1991 • 145 citations

Estimating Left Ventricular Filling Pressure during Positive End-Expiratory Pressure in Humans

1991 • 141 citations

Are Low Tidal Volumes Safe?

1990 • 140 citations

Overwhelming Pulmonary Blastomycosis Associated with the Adult Respiratory Distress Syndrome

1993 • 138 citations

Adult respiratory distress syndrome in neutropenic patients

1986 • 136 citations

Alveolo-capillary Permeability in Human Septic ARDS

1981 • 131 citations

Crack Lung: Pulmonary Disease Caused by Cocaine Abuse

1987 • 128 citations

Oxygen Delivery and Consumption and Ventricular Preload Are Greater in Survivors than in Nonsurvivors of the Adult Respiratory Distress Syndrome

1990 • 125 citations

CT detection of occult pneumothorax in head trauma

1984 • 125 citations

Established ARDS Treated with a Sustained Course of Adrenocortical Steroids

1990 • 125 citations

Effect of Almitrine on Ventilation-Perfusion Distribution in Adult Respiratory Distress Syndrome

1988 • 122 citations

Decreased serum interleukin 1 activity and monocyte interleukin 1 production in patients with fatal sepsis

1986 • 112 citations

Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure

1986 • 112 citations

Timing of Tracheotomy in Mechanically Ventilated Patients

1993 • 111 citations

A Successful Computerized Protocol for Clinical Management of Pressure Control Inverse Ratio Ventilation in ARDS Patients

1992 • 111 citations

Pulmonary interstitial emphysema in the adult respiratory distress syndrome

1985 • 109 citations

Mechanisms and Mediators of the Adult Respiratory Distress Syndrome

1990 • 106 citations

Pathology of the Adult Respiratory Distress Syndrome

1986 • 103 citations

A Prospective Study of Acute Hypoxic Respiratory Failure

1986 • 102 citations

A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group

1991 • 100 citations

Ketoconazole Prevents Acute Respiratory Failure in Critically Ill Surgical Patients

1988 • 95 citations

Diagnosis of Pneumonia in Mechanically Ventilated Patients: Repeatability of the Protected Specimen Brush

1993 • 93 citations

today's practice ot cardiopulmonary medicine

1984 • 91 citations

ADULT RESPIRATORY DISTRESS SYNDROME: DEFINITION AND HISTORICAL PERSPECTIVE

1982 • 89 citations

Effect of Tidal Volume on Gas Exchange and Oxygen Transport in the Adult Respiratory Distress Syndrome

1992 • 83 citations

Auto-PEEP during CPR

1991 • 79 citations

Adult respiratory distress syndrome associated with miliary tuberculosis

1985 • 77 citations

Comparison of high frequency jet ventilation to conventional ventilation during severe acute respiratory failure in humans

1982 • 77 citations

Predicting intensive care unit outcome with scoring systems. Underlying concepts and principles.

1994 • 75 citations

Preservation of normal lung regions in the adult respiratory distress syndrome. Analysis by computed tomography

1986 • 70 citations

Introduction of new technology into critical care practice

1993 • 69 citations

Barotrauma: Detection, Recognition, and Management

1993 • 66 citations

Treatment of adult respiratory distress syndrome with diuretics, dialysis, and positive end-expiratory pressure

1978 • 66 citations

Lung Mechanics in the Adult Respiratory Distress Syndrome

1990 • 64 citations

Predicting Intensive Care Unit Outcome with Scoring Systems: Underlying Concepts and Principles

1994 • 60 citations

Mechanisms of disease: are oxygen-derived free radicals involved in diaphragmatic dysfunction?

1994 • 59 citations

Severe Acute Respiratory Failure Managed with Continuous Positive Airway Pressure and Partial Extracorporeal Carbon Dioxide Removal by an Artificial Membrane Lung: A Controlled, Randomized Animal Study

1988 • 59 citations

A Positron Emission Tomographic Comparison of Pulmonary Vascular Permeability during the Adult Respiratory Distress Syndrome and Pneumonia

1991 • 58 citations

Non-Cardiac Or Cardiac Pulmonary Edema?

1983 • 57 citations

Intrinsic PEEP monitored in the ventilated ARDS patient with a mathematical method

1992 • 50 citations

Pulmonary Vascular Tone Improves Pulmonary Gas Exchange in the Adult Respiratory Distress Syndrome

1987 • 49 citations

Ventilatory Strategies in the Management of the Adult Respiratory Distress Syndrome

1990 • 45 citations

The Clinical Entity of Adult Respiratory Distress Syndrome: Definition, Prediction, and Prognosis

1986 • 45 citations

Pilot Study of Cardiopulmonary Risk from Pentoxifylline in Adult Respiratory Distress Syndrome

1993 • 44 citations

Effect of PEEP and type of injury on thermal-dye estimation of pulmonary edema

1986 • 43 citations

Temporal Trends in Hospital-based Episodes of Asthma Care in a Health Maintenance Organization

1993 • 42 citations

Cardiopulmonary Monitoring of Critically Ill Patients

1984 • 39 citations

Idiopathic Pulmonary Fibrosis

1991 • 38 citations

Bronchoalveolar Lavage in Patients with the Adult Respiratory Distress Syndrome

1985 • 37 citations

Worsening Oxygenation in the Mechanically Ventilated Patient: Causes, Mechanisms, and Early Detection

1988 • 36 citations

Comparison of high-frequency jet ventilation to conventional ventilation in adults with respiratory distress syndrome

1987 • 36 citations

The Heart Is Not Always in Good Hands

1990 • 36 citations

Tidal Volume Reduction in ARDS

1991 • 34 citations

Radiologic Considerations in the Adult Respiratory Distress Syndrome

1990 • 33 citations

Pulmonary microvascular permeability to fluid and macromolecules

1988 • 32 citations

Oxygen Toxicity

1990 • 29 citations

Clinical Measurement of Extravascular Lung Water

1986 • 26 citations

Ventilator Modes: Old and New

1990 • 25 citations

A physiologic approach to initiating, maintaining, and withdrawing mechanical ventilatory support during acute respiratory failure

1990 • 25 citations

Radiographic Differentiation Between Different Etiologies of Pulmonary Edema

1987 • 24 citations

Nitroprusside infusion does not improve biventricular performance in patients with acute hypoxemic respiratory failure

1986 • 21 citations

EXCESSIVE WORK OF BREATHING DURING INTERMITTENT MANDATORY VENTILATION

1986 • 20 citations

A Historical Perspective of Mechanical Ventilation *

1990 • 19 citations

Non-conventional Techniques of Ventilatory Support

1990 • 19 citations

Double Lung Transplantation for Adult Respiratory Distress Syndrome After Recombinant Interleukin 2

1993 • 19 citations

Pulmonary Endothelial Cell Injury and Altered Lung Metabolic Function

1990 • 16 citations

RADIOLOGIC CONSIDERATIONS IN THE ADULT RESPIRATORY DISTRESS SYNDROME TREATED WITH POSITIVE END EXPIRATORY PRESSURE (PEEP)

1982 • 15 citations

Lung hyperinflation caused by inappropriate ventilation resulting in electromechanical dissociation: a case report.

1992 • 14 citations

Gas Exchange in Acute Lung Injury

1986 • 13 citations

Oxygen Supply and Consumption in the Adult Respiratory Distress Syndrome

1990 • 11 citations

Oxygen delivery-consumption relationship in adult respiratory distress syndrome patients: The effects of sepsis

1993 • 11 citations

Acute respiratory failure due to Pneumocystis carinii pneumonia

1985 • 10 citations

Controlled Ventilation: Targets, Hazards and Options

1991 • 8 citations

Positive end-expiratory pressure and adult respiratory distress syndrome: What are we missing?

1992 • 1 citations

Deleted Work

1955 • 0 citations