Antibiotic Pharmacokinetics and Clinical Application in Renal Insufficiency

Countercurrent multiplication system without active transport in inner medulla

1972 • 492 citations

Binding of Drugs to Serum Albumin

1976 • 410 citations

GALLBLADDER INERTIA IN CŒLIAC DISEASE

1971 • 400 citations

Non-ionic diffusion and the excretion of weak acids and bases

1958 • 377 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: Gentamicin in burn patients

1976 • 356 citations

The route of absorption of intraperitoneally administered compounds.

1971 • 352 citations

Binding of Drugs by Albumin Plasma Protein

1977 • 329 citations

RAPID EVALUATION OF CREATININE CLEARANCE

1971 • 317 citations

The Nephrotoxicity of Antimicrobial Agents

1977 • 312 citations

KINETICS OF PERITONEAL DIALYSIS

1961 • 204 citations

Gentamicin Serum Concentrations: Pharmacokinetic Predictions

1976 • 193 citations

Metabolism of drugs by the kidney

1980 • 185 citations

Gentamicin Therapy in Renal Failure: A Nomogram for Dosage

1972 • 181 citations

Present knowledge of the counter-current system in the mammalian kidney

1961 • 177 citations

Drug Dosage in Renal Disease

1976 • 173 citations

The relation between the binding of sulfonamides to albumin and their antibacterial efficacy.

1960 • 171 citations

Protein Binding of Antimicrobials

1977 • 162 citations

THE BINDING OF ANTIBIOTICS TO SERUM PROTEINS

1965 • 156 citations

The aminoglycosides : microbiology, clinical use, and toxicology

1982 • 155 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

The Nephrotoxicity of Antimicrobial Agents

1977 • 148 citations

Binding of Antibiotics to Tissue Homogenates

1970 • 146 citations

Amikacin Serum Concentrations: Prediction of Levels and Dosage Guidelines

1978 • 146 citations

Clinical pharmacology of the new penicillins: I. The importance of serum protein binding in determining antimicrobial activity and concentration in serum

1966 • 142 citations

Effect of free fatty acids on binding of drugs by bovine serum albumin, by human serum albumin and by rabbit serum.

1971 • 129 citations

Drug Therapy in Renal Failure: Dosing Guidelines for Adults

1980 • 119 citations

Renal Failure, Drug Pharmacokinetics and Drug Action

1976 • 110 citations

Guidelines for Drug Therapy in Renal Failure

1977 • 104 citations

A drug-induced change in the distribution and renal excretion of sulfonamides.

1961 • 99 citations

Concentrations of Gentamicin and Amikacin in Human Kidneys

1976 • 95 citations

Drug Kinetics and Artificial Kidneys1

1977 • 87 citations

Multiple Dose Kinetics and Drug Dosage in Patients with Kidney Disease

1971 • 84 citations

Removal and Absorption of Antibiotics in Patients with Renal Failure Undergoing Peritoneal Dialysis

1967 • 80 citations

Plasma protein binding and distribution characteristics of drugs as indices of their hemodialyzability

1978 • 76 citations

INCREASING THE SUPPLY OF CADAVERIC KIDNEYS FOR TRANSPLANTATION

1981 • 76 citations

Intrarenal antibiotic distribution in health and disease

1974 • 76 citations

The Binding of Drugs to Plasma Proteins from Patients with Poor Renal Function

1976 • 75 citations

Effect of plasma protein and tissue binding on the biologic half‐life of drugs

1978 • 75 citations

Principles of dialysis and dialysis of drugs

1977 • 72 citations

Mechanisms of Drug Absorption and Excretion

1964 • 71 citations

Doxycycline pharmacokinetics in the absence of renal function

1974 • 60 citations

Renal Excretion of Drugs: Tubular Transport and Metabolism

1972 • 58 citations

Some Considerations as to the Determination and Significance of Biologic Half-Life

1971 • 55 citations

INHIBITORS OF PENICILLIN BINDING TO SERUM PROTEINS.

1965 • 50 citations

Therapeutic Implications of Gentamicin Accumulation in Severely Diseased Kidneys

1976 • 48 citations

Biopharmaceutics and clinical pharmacokinetics

1980 • 48 citations

Dosage Regimen Adjustments in Renal Impairment

1973 • 46 citations

A rapid, modified ultrafiltration method for determining serum protein binding and its application to new penicillins.

1965 • 46 citations

Mechanisms of Drug Absorption and Excretion The Renal Excretion of Drugs and Related Compounds

1967 • 45 citations

Gentamicin Gradient Patterns and Morphological Changes in Human Kidneys

1977 • 45 citations

Urinary Tract Infections in Patients With Severe Renal Disease

1976 • 44 citations

Intraperitoneal Administration of Broad-Spectrum Antibiotics in Patients With Renal Failure

1965 • 43 citations

Renal function and drug action

1971 • 42 citations

Comparison of the intrarenal disposition of tobramycin and gentamicin: therapeutic and toxicologic answers

1978 • 41 citations

Drugs and Peritoneal Dialysis

1983 • 40 citations

The effect of disease, drugs, and dilution on the binding of sulfonamides in human plasma

1968 • 39 citations

Enhancement of Antimicrobial Activity of Penicillins and Other Antibiotics in Human Serum by Competitive Serum Binding Inhibitors.

1964 • 38 citations

A New Approach to Studying the Protein-Binding Properties of Penicillins

1963 • 37 citations

The binding capacity of albumin and renal disease.

1974 • 37 citations

Renal excretion of urate: Factors determining the actions of drugs

1980 • 37 citations

Peritoneal Transport of Antibiotics in Man

1965 • 32 citations

Intrarenal distribution of penicillin, cephalothin, ampicillin and oxytetracycline during varied states of hydration.

1971 • 30 citations

Pharmacokinetics and dosing of antimicrobial agents in renal impairment, part ii

1974 • 26 citations

Intrarenal Distribution of Ampicillin in the Normal and Diseased Human Kidney

1972 • 21 citations

Gentamicin concentrations in blood, urine, and renal tissue of patients with end-stage renal disease.

1977 • 21 citations

Protein Binding of Semisynthetic Penicillins

1964 • 20 citations

Antibacterial Chemotherapy in Renal Insufficiency

2015 • 19 citations

Tetracyclines in renal insufficiency: resolution of a therapeutic dilemma.

1978 • 19 citations

Carbenicillin Concentrations in Normal and Diseased Kidneys

1973 • 17 citations

Clinical Pharmacology of Gentamicin in the Newborn Infant

1972 • 17 citations

Absorption of antibiotics during peritoneal dialysis in patients with renal failure

1968 • 17 citations

Drugs and Renal Disease.

1979 • 16 citations

Pharmacokinetic Characteristics of Doxycycline Acwmulation in Normal and Severely Diseased Kidneys

1975 • 15 citations

Antibiotic Usage in Patients with Renal Impairment

1972 • 13 citations

Water movement across nephron segments involved with the countercurrent multiplication system

1976 • 12 citations

Modification of drug therapy in chronic dialysis patients.

1975 • 12 citations

RENAL TRANSPLANTATION IN THE INBRED RAT

1969 • 11 citations

Concentration of Antibiotics in Simple Renal Cysts

1980 • 11 citations

Double-Blind Comparison of Phlebitis Produced by Cephalothin Infusions with Buffered and Unbuffered Diluents

1974 • 9 citations

The use of gentamicin in urinary tract infections with special reference to drug levels in complicated (urological) infections.

1974 • 4 citations

Protein binding of drugs--the clinical significance.

1978 • 4 citations

An approach to the interpretation of drug concentrations in the kidney.

1978 • 4 citations

NOMOGRAMS FOR ANTIBIOTIC DOSAGE IN ADULTS

1975 • 3 citations

Gentamicin in acute and chronic pyelonephritis.

1973 • 2 citations

Clinical implications of protein binding of drugs.

1978 • 2 citations

Dosage of chemotherapeutic agents in patients with renal disease.

1979 • 1 citations