Primary biliary cirrhosis

Primary Biliary Cirrhosis

1987 • 1,981 citations

Hepatogastroenterology

2012 • 1,367 citations

Primary Biliary Cirrhosis

2011 • 1,245 citations

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

1997 • 624 citations

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.

1987 • 557 citations

SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

1965 • 504 citations

Ursodiol for the Long-Term Treatment of Primary Biliary Cirrhosis

1994 • 477 citations

Ursodeoxycholic acid in the treatment of primary biliary cirrhosis

1994 • 474 citations

Primary Biliary Cirrhosis

1996 • 442 citations

The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

1994 • 431 citations

PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

1988 • 298 citations

Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

1988 • 277 citations

A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis*1

1995 • 275 citations

Immunomodulatory Effects of Ursodeoxycholic Acid on Immune Responses

1992 • 235 citations

Autoimmune associations in primary biliary cirrhosis.

1982 • 223 citations

Primary Biliary Cirrhosis: A Model Autoimmune Disease

1983 • 220 citations

Detection of Autoantibodies to Recombinant Mitochondrial Proteins in Patients with Primary Biliary Cirrhosis

1989 • 206 citations

Primary biliary cirrhosis

1997 • 180 citations

Trial of Penicillamine in Advanced Primary Biliary Cirrhosis

1985 • 167 citations

Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years

1994 • 166 citations

Diminished survival in asymptomatic primary biliary cirrhosis

1990 • 141 citations

Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.

1991 • 139 citations

Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

1989 • 125 citations

Is mitochondrial antibody diagnostic of primary biliary cirrhosis?

1981 • 121 citations

Antimitochondrial antibodies in primary biliary cirrhosis

1986 • 115 citations

Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway.

1996 • 113 citations

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.

1990 • 107 citations

Primary biliary cirrhosis and mitochondrial autoantigens—insights from molecular biology

1988 • 99 citations

Deficiency of the autologous mixed lymphocyte reaction in patients with primary biliary cirrhosis.

1980 • 95 citations

Increased incidence of hypothyroidism in primary biliary cirrhosis

1983 • 87 citations

Liver cell uptake and degradation of soluble immunoglobulin G immune complexesin vivoandin vitroin rats

1996 • 63 citations

T-cell responses to the components of pyruvate dehydrogenase complex in primary biliary cirrhosis

1995 • 61 citations

Cost-effectiveness of ursodeoxycholic acid therapy in primary biliary cirrhosis

1999 • 53 citations

High prevalence of antibodies to recombinant CENP‐B in primary biliary cirrhosis: Nuclear immunofluorescence patterns and ELISA reactivities

1995 • 47 citations

Primary biliary cirrhosis

2011 • 45 citations

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-γ upon mitogen stimulation

1992 • 44 citations

Autoantibodies to mitochondria in systemic sclerosis. frequency and characterization using recombinant cloned autoantigen

1988 • 44 citations

Platelet associated immunoglobulins in primary biliary cirrhosis: a cause of thrombocytopenia?

1985 • 44 citations

Lymphocyte Subsets in Primary Biliary Cirrhosis

1984 • 38 citations

Anti‐acetylcholine Receptor Antibodies in Primary Biliary Cirrhosis

1985 • 35 citations

Anti-pyruvate dehydrogenase autoantibodies in primary biliary cirrhosis

1991 • 30 citations

Autoantibodies to histones and their subfractions in chronic liver diseases

1989 • 26 citations

Deficient interleukin-2 responsiveness of T lymphocytes from patients with primary biliary cirrhosis

1992 • 25 citations

Lymphocytotoxic antibodies in primary biliary cirrhosis

1985 • 16 citations

Antinuclear autoantibodies in chronic liver diseases.

1989 • 16 citations

Detection of Antimitochondrial Antibodies: Characterization by Enzyme Immunoassay and Immunoblotting

1989 • 14 citations

Demonstration of Immune Complexes Containing the Ribonucleoprotein Antigen Ro in Primary Biliary Cirrhosis

1986 • 13 citations

Reduced numbers of CD8+ T cells and B cell-expression of Leu-8 antigen in peripheral blood of patients with primary biliary cirrhosis.

1994 • 12 citations

New therapeutic avenues in autoimmunity

1996 • 12 citations

Primary biliary cirrhosis and autoimmune rheumatic diseases: prediction and prevention.

1992 • 8 citations

T cell autoreactivity against a 28 kD biliary protein (B1-p28) in primary biliary cirrhosis

1995 • 4 citations