Pharmacology and Neurochemistry of Apomorphine

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Electrical Signs of Selective Attention in the Human Brain

1973 • 1,881 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

Aromatic Amino Acids and Modification of Parkinsonism

1967 • 1,464 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

Presynaptic regulation of catecholamine release

1974 • 1,145 citations

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

Cardiovascular and renal actions of dopamine: potential clinical applications.

1972 • 1,034 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”

1972 • 1,022 citations

The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs

1954 • 1,014 citations

Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats

1967 • 911 citations

Evidence for dopamine receptor stimulation by apomorphine

1967 • 910 citations

PRE AND POSTSYNAPTIC RECEPTORS

1976 • 778 citations

The distribution of substance P and 5‐hydroxytryptamine in the central nervous system of the dog

1954 • 695 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Physiology and pharmacology of vomiting.

1953 • 684 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

PREVENTION OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM IN INJURED PATIENTS

1959 • 650 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Release of dopamine from dendrites in rat substantia nigra

1976 • 644 citations

6-Hydroxydopamine and catecholamine neurons

1971 • 637 citations

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 • 590 citations

Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat.

1953 • 588 citations

Induction of Mating Behavior in Rats by Luteinizing Hormone-Releasing Factor

1973 • 533 citations

Luteinizing Hormone-Releasing Factor Potentiates Lordosis Behavior in Hypophysectomized Ovariectomized Female Rats

1973 • 512 citations

The Pharmacology of Tardive Dyskinesias

1973 • 512 citations

Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals

1975 • 482 citations

Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens

1973 • 477 citations

The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.

1970 • 475 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines

1974 • 451 citations

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs

1974 • 450 citations

Antiamphetamine effects following inhibition of tyrosine hydroxylase.

1966 • 445 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.

1968 • 435 citations

Evidence for dopamine receptors mediating sedation in the mouse brain

1976 • 421 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Regional distribution of substance P in the brain of the rat

1976 • 417 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission

1971 • 415 citations

Effect of ergot drugs on central catecholamine neurons: Evidence for a stimulation of central dopamine neurons

1973 • 394 citations

Central dopaminergic neurons: Effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid

1976 • 363 citations

The permeability of the hypophysis and hypothalamus to vital dyes, with a study of the hypophyseal vascular supply

1936 • 358 citations

Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine

1973 • 350 citations

Experimental study of the projections of the nucleus of the tractus solitarius and the area postrema in the cat

1967 • 345 citations

DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITY

1974 • 342 citations

Morphine catalepsy in the rat: relation to striatal dopamine metabolism

1972 • 338 citations

Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat

1969 • 331 citations

Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats

1966 • 330 citations

Galactorrhoea: Successful Treatment with Reduction of Plasma Prolactin Levels by Brom-ergocryptine

1972 • 318 citations

Catecholamine receptor agonists

1976 • 318 citations

Role of Cyclic Amp in Cell Function

1970 • 317 citations

Stimulation of Human-Growth-Hormone Secretion by L-Dopa

1970 • 304 citations

Frontiers in Neuroendocrinology, 1973.

1973 • 302 citations

Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3′:5′-Cyclic Monophosphate Formation in Intact Retina

1972 • 286 citations

Similarities between Neurologic Effects of L-Dopa and of Apomorphine

1970 • 271 citations

Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine

1973 • 263 citations

Ascending catecholamine pathways and amphetamine-induced locomotor activity: Importance of dopamine and apparent non-involvement of norepinephrine

1975 • 259 citations

The Role of Catecholamines in the Release of Anterior Pituitary Prolactinin Vitro

1974 • 255 citations

Amphetamine: Differentiation by d and l Isomers of Behavior Involving Brain Norepinephrine or Dopamine

1970 • 252 citations

Dopamine release in substantia nigra?

1976 • 249 citations

Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia

1974 • 245 citations

Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture

1977 • 243 citations

Regulation of monoamine metabolism in the central nervous system.

1972 • 241 citations

Effects of dopaminergic receptor agonists and antagonists on the activity of the neo-striatal cholinergic system

1975 • 236 citations

Tardive Dyskinesia in Patients Treated with Major Neuroleptics: A Review of the Literature

1968 • 235 citations

Involvement of nigro-striatal neurons in the in vivo release of dopamine by amphetamine, amantadine and tyramine.

1973 • 229 citations

Effect of drugs used in psychoses on cerebral dopamine metabolism

1970 • 226 citations

Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α-receptors

1973 • 225 citations

Persistent Dyskinesia

1973 • 222 citations

The role of telencephalic dopaminergic systems in the mediation of apomorphine-sterrotyped behaviour

1973 • 222 citations

Dopamine receptor binding in the corpus striatum of mammalian brain.

1975 • 221 citations

Psychotomimetic drugs

1971 • 217 citations

A New Concept of Organization of the Central Emetic Mechanism: Recent Studies on the Sites of Action of Apomorphine, Copper Sulfate And Cardiac Glycosides

1952 • 214 citations

Dopamine and noradrenaline receptor stimulation: Reversal of reserpine-induced suppression of motor activity

1973 • 210 citations

Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow.

1974 • 208 citations

Turning behavior of mice with unilateral 6-hydroxydopamine lesions in the striatum: Effects of apomorphine, l-DOPA, amantadine, amphetamine and other psychomotor stimulants

1973 • 204 citations

THE INHIBITION OF PROLACTIN SECRETION IN MAN BY CB-154 (2-Br-α-ergocryptine)

1972 • 201 citations

GASTRIN SEGRETION IN THE PANCREAS?

1970 • 200 citations

INTRAVENOUS FEEDING

1974 • 200 citations

DECREASED PLASMA GROWTH HORMONE (GH) LEVELS IN ACROMEGALICS FOLLOWING CB 154(2-Br-α-ERGOCRYPTINE) ADMINISTRATION¹

1974 • 198 citations

Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol

1974 • 195 citations

Area postrema: Chemoreceptor trigger zone for vomiting - is that all?

1974 • 188 citations

Effect of Apomorphine on Growth Hormone, Prolactin, Luteinizing Hormone and Follicle-Stimulating Hormone Levels in Human Serum¹

1973 • 187 citations

Drug‐induced changes in the release of [³H]‐noradrenaline from field stimulated rat iris

1971 • 186 citations

Catecholamine Inhibition of Prolactin Secretion by Isolated Rat Adenohypophyses¹

1970 • 186 citations

Clinical and Hormonal Response To Bromocriptin (CB-154) in the Galactorrhea Syndromes

1974 • 186 citations

Observations on the fine structure of the substantia nigra in the cat

1970 • 185 citations

Effects of amphetamine on the turnover rate of brain catecholamines and motor activity

1972 • 178 citations

Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

1965 • 176 citations

ET495 and brain catecholamine mechanisms: Evidence for stimulation of dopamine receptors

1972 • 176 citations

CHLORPROMAZINE STIMULATION AND L-DOPA SUPPRESSION OF PLASMA PROLACTIN IN MAN¹

1971 • 174 citations

Effect of chlorpromazine on accumulation and disappearance of catecholamines formed from tyrosine-C14 in brain.

1968 • 171 citations

Behavioural effects in rats of morphine and amphetamine and of a combination of the two drugs

1970 • 167 citations

Die enzymatische Entstehung von Oxytyramin im Organismus und die physiologische Bedeutung der Dopadecarboxylase

1942 • 167 citations

The role of presynaptic receptors in the release and synthesis of 3H-dopamine by slices of rat striatum

1976 • 166 citations

Changes in Plasma Growth Hormone Levels in Normal and Acromegalic Subjects Following Administration of 2-Bromo-α-Ergocryptine

1975 • 164 citations

Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.

1976 • 161 citations

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum.

1976 • 160 citations

Effects of Amygdaloid Lesions upon Septal Hyperemotionality in the Rat

1958 • 158 citations

Central Effects of Anticholinergic Drugs Measured by the Apomorphine Gnawing Test in Mice

1969 • 155 citations

Suppression of Prolactin Release by a Purified Porcine PIF Preparation and Catecholamines Infused into a Rat Hypophysial Portal Vessel

1974 • 154 citations

2-Br-α-Ergokryptin: Beeinflussung von Fertilität und Laktation bei der Ratte

1968 • 154 citations

d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway

1976 • 153 citations

Prolactin and Growth Hormone Production as Influenced by Catecholamines and Agents that Affect Brain Catecholamines

1970 • 152 citations

Evidence for a new type of dopamine receptor stimulating agent

1971 • 152 citations

On the mode of action of apomorphine

1973 • 152 citations

Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topography

1974 • 151 citations

Self-injection of apomorphine in the rat: Positive reinforcement by a dopamine receptor stimulant

1974 • 147 citations

Localization of Nigral Dopamine-Sensitive Adenylate Cyclase on Neurons Originating from the Corpus Striatum

1977 • 147 citations

α- and β-Adrenergic Receptors as Mediators of Accumulation of Cyclic Adenosine 3',5'-Monophosphate in Specific Areas of Guinea Pig Brain

1971 • 143 citations

Influence of Norepinephrine and Catecholamine-Depleting Agents on the Synthesis and Release of Prolactin and Growth Hormone¹

1969 • 143 citations

Effects of Neuroleptics on Striatal Tyrosine Hydroxylase: Changes in Affinity for the Pteridine Cofactor

1974 • 141 citations

Decrease in homovanillic acid as evidence for dopamine receptor stimulation by apomorphine in the neostriatum of the rat

1969 • 140 citations

Treatment of Tardive Dyskinesia

1972 • 140 citations

Cellular localization of monoamines in the area postrema of certain mammals

1965 • 140 citations

Mode of Action of Psychomotor Stimulant Drugs

1970 • 139 citations

Morphology of Emetic Chemoreceptor Trigger Zone in Cat Medulla Oblongata

1951 • 138 citations

TREATMENT OF PARKINSONISM WITH BROMOCRIPTINE

1974 • 137 citations

Suppression of Puerperal Lactation with an Ergot Alkaloid: A Double-blind Study

1972 • 137 citations

Pharmacologically Induced Behavioural Supersensitivity to Apomorphine

1973 • 136 citations

Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists

1975 • 134 citations

The Comparative Pharmacology of Flupenthixol and some Reference Neuroleptics

1973 • 133 citations

Dopamine-Sensitive Adenylate Cyclase Occurs in a Region of Substantia Nigra Containing Dopaminergic Dendrites

1976 • 132 citations

Effects of 6-Hydroxydopamine on CNS Catecholamines, Spontaneous Motor Activity and Amphetamine Induced Hyperactivity in Rats

1970 • 131 citations

Injected Apomorphine and Orally Administered Levodopa in Parkinsonism

1972 • 130 citations

An investigation of the structural requirements for dopamine-like renal vasodilation: phenylethylamines and apomorphine.

1968 • 129 citations

INCREASE IN THE CONTENT OF ADENOSINE 3′5′‐ MONOPHOSPHATE IN MOUSE FOREBRAIN DURING SEIZURES AND PREVENTION OF THE INCREASE BY METHYLXANTHINES

1971 • 126 citations

Comparative Psychotomimetic Effects of Stereoisomers of Amphetamine

1971 • 125 citations

Inhibition by dopamine of 3H-noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane

1975 • 124 citations

Selective potentiation of locomotor effects of amphetamine by midbrain raphé lesions

1972 • 119 citations

Aminergic mechanisms in corpus striatum and amphetamine-induced stereotyped behaviour

1967 • 119 citations

Treatment of Non-puerperal Galactorrhoea with an Ergot Alkaloid

1971 • 119 citations

Behavioral effects of l-Dopa in schizophrenic patients

1973 • 119 citations

Effects on self-stimulation behavior of drugs influencing dopaminergic neurotransmission mechanisms

1973 • 118 citations

A dopamine‐stimulated adenylate cyclase in rat substantia nigra

1976 • 116 citations

6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats

1974 • 116 citations

Ergometrine induced locomotor activity following intracerebral injection into the nucleus accumbens

1973 • 113 citations

Inhibitory role of dopamine and 5-hydroxytryptamine in the sexual behaviour of female rats

1974 • 113 citations

EVIDENCE THAT METHADONE BLOCKS DOPAMINE RECEPTORS IN THE BRAIN

1972 • 111 citations

Effect of apomorphine on motility in rats

1972 • 111 citations

Dopamine receptors: A review

1971 • 110 citations

Postsynaptic receptors are not essential for dopaminergic feedback regulation

1977 • 110 citations

Dopamine-sensitive adenylate cyclase of the caudate nucleus of rats treated with morphine or haloperidol

1975 • 110 citations

Involvement of brain cholinergic mechanisms in the action of chlorpromazine

1974 • 110 citations

Influence of neuroleptic drugs and apomorphine on dopamine‐sensitive adenylate cyclase of retina

1973 • 110 citations

Inhibitory Effect of Dopaminergic Stimulation on GH Release in Acromegaly

1974 • 110 citations

Treatment of Tardive Dyskinesia

1972 • 110 citations

Serotonin synthesis inhibition and estrous behavior in female rats

1970 • 110 citations

Comportement d'agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1970 • 109 citations

Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed rat

1973 • 109 citations

Differences in the nature of the stereotyped behaviour induced by aporphine derivatives in the rat and in their actions in extrapyramidal and mesolimbic brain areas

1975 • 108 citations

Release of Brain Dopamine as the Probable Mechanism for the Hypothermic Effect of D-Amphetamine

1972 • 107 citations

Hypothermic effect of apomorphine in the mouse

1972 • 105 citations

Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis

1974 • 105 citations

Antagonistic effects of apomorphine and haloperidol on rat striatal synaptosomal tyrosine hydroxylase

1974 • 105 citations

Haloperidol increases and apomorphine decreases striatal dopamine metabolism after destruction of striatal dopamine-sensitive adenylate cyclase by kainic acid

1977 • 104 citations

Influence of ?-receptor stimulants on noradrenaline release

1971 • 104 citations

The effect of drugs acting on dopamine receptors on the body temperature of the rat

1972 • 104 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes

1974 • 104 citations

Possible stimulatory role of brain dopamine in the copulatory behavior of male rats

1974 • 103 citations

Antipsychotic Drugs and Dopamine-Stimulated Adenylate Cyclase Prepared from Corpus Striatum of Rat Brain

1974 • 102 citations

Cholinergic-dopaminergic interaction in the striatum: The effect of 6-hydroxydopamine or pimozide treatment on the increased striatal acetylcholine levels induced by apomorphine, piribedil andD-amphetamine

1975 • 98 citations

Behavioral effects of dopamine and p-hydroxyamphetamine injected into corpus striatum of rats

1971 • 96 citations

Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline

1971 • 94 citations

Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine.

1975 • 94 citations

EFFECT OF APOMORPHINE ON HUMAN-GROWTH-HORMONE SECRETION

1972 • 94 citations

A study of the structure of the area postrema with Golgi methods

1960 • 93 citations

Effect of apomorphine and pimozide on synthesis and turnover of labelled catecholamines in mouse brain

1970 • 93 citations

The inhibition of catecholamine biosynthesis by apomorphine

1970 • 93 citations

Inhibition of Rat Prolactin Release by Apomorphinein Vivoandin Vitro

1974 • 91 citations

Influence of ergot alkaloids on pituitary prolactin and prolactin‐dependent processes

1973 • 91 citations

Evidence on the cellular localization of adenyl cyclase in the neostriatum

1976 • 91 citations

Further studies on the possible interaction between dopamine and noradrenaline containing neurons in the brain

1970 • 91 citations

Beiträge zur Pharmakologie des Gehirns

1923 • 90 citations

Role of the tuberculum olfactorium in stereotyped behaviour induced by apomorphine in the rat

1972 • 90 citations

Supersensitivity to dopamine agonists following unilateral, 6-hydroxydopamine-induced striatal lesions in mice.

1975 • 87 citations

Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio

1975 • 86 citations

The substantia nigra and stereotyped behaviour

1972 • 85 citations

Apomorphine-induced aggression in the rat

1971 • 85 citations

Substantia nigra of the rat contains a dopamine sensitive adenylate cyclase

1976 • 84 citations

Evidence for dopamine receptors in the human brain mediating sedation and sleep

1977 • 84 citations

EFFECT OF PSYCHOTHERAPEUTIC DRUGS ON HYPEREMOTIONALITY OF RATS IN WHICH THE OLFACTORY BULB WAS REMOVED

1967 • 84 citations

Is the dopamine sensitive adenylate cyclase in the rat substantia nigra coupled with ‘autoreceptors’?

1976 • 83 citations

Subjective and Penile Plethysmograph Responses Following Aversion-Relief and Apomorphine Aversion Therapy for Homosexual Impulses

1969 • 82 citations

Apomorphine in huntington's chorea: Clinical observations and theoretical considerations

1974 • 82 citations

Altered response to apomorphine in 6-hydroxydopamine-treated rats

1972 • 82 citations

CHLORPROMAZINE AND ENDOCRINE FUNCTION

1967 • 81 citations

The effect of narcotic analgesics on the homovanillic acid content of rat nucleus caudatus

1973 • 81 citations

The effect of trivastal, haloperidol and dibutyryl cyclic AMP on [14C]dopamine synthesis in rat striatum

1973 • 81 citations

Inhibition of Thyrotropin and Prolactin Secretions in Primary Hypothyroidism by 2-Br-α-ergocryptine

1974 • 81 citations

Effects of 2-Br-α-ergocryptine on plasma prolactin level and milk yield in cows

1972 • 79 citations

Inhibition of Prolactin Secretion and Successful Therapy of the Forbes-Albright Syndrome with<scp>l</scp>-Dopa*

1972 • 76 citations

Inhibition by Apomorphine of Prolactin Secretion in Patients with Elevated Serum Prolactin

1974 • 76 citations

STUDIES ON VOMITING

1923 • 76 citations

Supersensitivity of caudate neurones after repeated administration of haloperidol

1975 • 75 citations

Effect of several dopaminergic drugs and trihexyphenidyl on cholinergic parameters in the rat striatum

1974 • 75 citations

Estrus behaviour in spayed rats after estrogen or progesterone treatment in combination with reserpine or tetrabenazine

1964 • 75 citations

The effect of dopamine and other compounds on the activity of neurones ofHelix aspersa; Structure-activity relationships

1969 • 75 citations

Apomorphine and amphetamine stereotypy after 6-hydroxydopamine lesions of the substantia nigra

1974 • 73 citations

Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors

1975 • 71 citations

Intracranial self-stimulation in rats as a function of various stimulus parameters

1973 • 71 citations

Adrenergic Effect of Chronic Administration of Neuroleptics

1967 • 70 citations

Increased release of dopamine from striatal dopaminergic terminals in the rat after treatment with a neuroleptic: Thioproperazine

1970 • 70 citations

Application of steady-state kinetics to the study of catecholamine turnover after monoamine oxidase inhibition or reserpine administration.

1968 • 69 citations

Observations on the effect of levodopa on tardive lingual-facial-buccal dyskinesia

1971 • 69 citations

[Fine structure of the subfornical organ of the dog].

1965 • 69 citations

A re‐evaluation of the cellular morphology of the area postrema in view of recent evidence for a chemoreceptor function

1954 • 69 citations

Comparison of excited phases alter sedatives and tranquilizers

1960 • 69 citations

Hypothalamic Control of Lactation

1970 • 69 citations

A comparison of effects of apomorphine and ET495 on locomotor activity and circling behaviour in mice☆

1974 • 68 citations

Studies of various amphetamines, apomorphine and clonidine on body temperature and brain 5-hydroxytryptamine metabolism in rats

1974 • 68 citations

Drug Effects and Hypothalamic-Anterior Pituitary Function

1974 • 66 citations

Drug Induced Changes in ³H‐Catecholamine Accumulation after ³H‐Tyrosine

1970 • 66 citations

Effects of apomorphine, (+)-amphetamine, and nialamide on tetrabenazine-induced suppression of sexual behavior in the male rat

1969 • 66 citations

Locus of emetic action of morphine and hydergine in dogs.

1954 • 65 citations

Norepinephrine Stimulated Increase of Cyclic AMP Levels in Developing Mouse Brain Cell Cultures

1971 • 64 citations

Enhancement of apomorphine-induced inhibition of striatal dopamine-turnover following chronic haloperidol

1975 • 63 citations

[Inhibition of prolactin secretion by ergocornine and 2-Br-alpha-ergocryptine: direct action on the hypophysis in culture].

1971 • 63 citations

Stimulation of a dopamine-sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495)

1974 • 62 citations

Possible Role of Cyclic AMP and Prostaglandin E₁in the Dopaminergic Control of Prolactin Release

1974 • 62 citations

Role of catecholamines in the anorectic effects of amphetamine in rats

1974 • 61 citations

The conformation of dopamine hydrochloride

1971 • 61 citations

Possible involvement of brain serotonin in apomorphine-induced hypothermia

1973 • 61 citations

Effect of Anterior Pituitary Perfusion and Intraventricular Injection of Catecholamines on FSH Release1

1971 • 61 citations

Zum Feinbau des Subfornikal-Organs der Katze

1966 • 60 citations

Stable Reduction of Plasma Growth Hormone (hGH) Levels During Chronic Administration of 2-Br-α-ergocryptine (CB-154) in Acromegalic Patients

1975 • 60 citations

Antagonism of apomorphine-induced stereotypy and emesis in dogs by thioridazine, haloperidol, and pimozide

1972 • 59 citations

The histochemistry of the mammalian area postrema

1949 • 59 citations

Evidence for a sequestration of function within the area postrema based on scanning electron microscopy and the penetration of horseradish peroxidase

1971 • 59 citations

Dopaminergic nature of apomorphine-induced pecking in pigeons

1974 • 58 citations

Der Feinbau des Subfornikalorganes vom Hund

1965 • 58 citations

Effects of apomorphine and amphetamine on schedule-controlled behavior: Reversal of tetrabenazine suppression and dopaminergic correlates

1969 • 58 citations

Reduction of food intake by apomorphine: A pimozide-sensitive effect

1973 • 57 citations

Evidence for selective and long-lasting stimulation of “regulatory” dopamine-receptors by bromocriptine (CB 154)

1977 • 57 citations

CATECHOLAMINE INDUCED INCREASE OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN RAT BRAIN IN VIVO

1972 • 57 citations

Different sensitivities of the phosphodiesterases (adenosine-3′,5′-cyclic phosphate 3′-phosphohydrolase) of dog cerebral cortex and erythrocytes to inhibition by synthetic agents and cold

1971 • 57 citations

Preliminary investigation of the metabolism of piribedil (ET 495); a new central dopaminergic agonist and potential anti-parkinson agent

1973 • 57 citations

Bizarre social behaviour in rats induced by a combination of a peripheral decarboxylase inhibitor and DOPA

1968 • 56 citations

Neurochemical evidence for denervation supersensitivity: The effect of unilateral substantia nigra lesions on apomorphine-induced increases in neostriatal acetylcholine levels

1974 • 55 citations

Changes of kinetic constant of striatal tyrosine hydroxylase elicited by neuroleptics that impair the function of dopamine receptors

1974 • 55 citations

The involvement of dopaminergic systems with the stereotyped behaviour patterns induced by methylphenidate

1974 • 54 citations

Aporphines. 8. Total Synthesis and Pharmacological Evaluation of (±)-Apomorphine, (±)-Apocodeine, (±)-N-n-Propylnorapomorphine, and (±)-N-n--Propylnorapocodeine

1973 • 54 citations

Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11-methoxyaporphine (Isoapocodeine). In vitro enzymic methylation of apomorphine

1972 • 54 citations

Synthesis and pharmacology of centrally acting dopamine derivatives and analogs in relation to Parkinson's disease

1973 • 54 citations

Evidence for a luteolytic function of prolactin in the intact cyclic rat using 2-Br-α-ergokryptine (CB 154)

1971 • 54 citations

Amphetamine Psychosis

1957 • 54 citations

Extra-Blood-Brain-Barrier Brain Structures

1967 • 53 citations

The role of brain norepinephrine in the anorexic effects of dextroamphetamine and monoamine oxidase inhibitors in the rat

1971 • 53 citations

Biochemical aspects of dopamine agonists.

1975 • 53 citations

Ueber die Wirkungen des Apomorphins am Säugethier und am Frosch

1874 • 53 citations

Absence of serotonergic influence on apomorphine-induced stereotypy

1972 • 52 citations

Effects of aporphine and emetine alkaloids on central dopaminergic mechanisms in rats

1972 • 52 citations

The Chemoreceptor Trigger Zone for Emesis in the Monkey

1955 • 51 citations

Comparison of structural and stereoisomers of apomorphine on stereotyped sniffing behavior of the rat

1975 • 51 citations

Effect of Apomorphine on Growth Hormone Release in Humans¹

1973 • 51 citations

2-(2-Cycloalkanonyl)-1,3-dithiolanes as radioprotective agents

1973 • 51 citations

Apomorphine provoked stereotypy in the dog

1972 • 50 citations

Self-inhibition by dopaminergic neurones: Disruption by (±)-α-methyl-p-tyrosine pretreatment or anterior diencephalic lesions

1976 • 50 citations

Treatment of galactorrhea-amenorrhea syndrome with Br-ergocryptine (CB 154): Restoration of ovulatory function and fertility

1973 • 50 citations

Drug-induced syndromes in rats with large, chronic lesions in the corpus striatum

1972 • 49 citations

Subjective and Penile Plethysmograph Responses to Aversion Therapy for Homosexuality: A Follow-up Study

1970 • 49 citations

Behavioural evidence of dopamine receptor stimulation by piribedil (ET495) and its metabolite S584

1974 • 49 citations

TREATMENT OF DRUG-INDUCED DYSKINESIAS

1970 • 48 citations

Fine structure of the area postrema of the rabbit brain

1964 • 48 citations

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY

1973 • 48 citations

Levodopa in the Treatment of Parkinsonism

1971 • 48 citations

A pimozide-sensitive effect of apomorphine on body temperature of the rabbit

1972 • 47 citations

Effects of L-Dopa on Serum Prolactin and PIF in Intact and Hypophysectomized, Pituitary-Grafted Rats

1972 • 47 citations

The induction and antagonism of central nervous system stimulant-induced stereotyped behavior in the cat

1972 • 47 citations

The effect of dopamine and of apomorphine on dB-cAMP-induced stimulation of synaptosomal tyrosine hydroxylase

1974 • 47 citations

Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine

1973 • 46 citations

Effects of apomorphine on self-stimulation behavior

1974 • 45 citations

On the role of serotonin in apomorphine-induced locomotor stimulation in rats

1974 • 45 citations

Centrally acting emetics. 6. Derivatives of .beta.-naphthylamine and 2-indanamine

1972 • 44 citations

Differential effects of amphetamine, fenfluramine and norfenfluramine stereoisomers on the increase of striatum homovanillic acid in rats

1973 • 44 citations

The anti-emetic activity of 10-(gamma-dimethylaminopropyl)-2-chlorophenothiazine (chlorpromazine) in dog and cat.

1954 • 44 citations

Apomorphine in Parkinsonian tremor.

1970 • 44 citations

Influence of midbrain raphe lesion on some pharmacological and biochemical effects of apomorphine in rats

1974 • 43 citations

The Role of Brain Monoamines and Pineal Indoles in the Secretion of Gonadotrophins and Gonadotrophin-Releasing Factors

1973 • 43 citations

Effect of nigral lesion on chlorpromazine-induced acceleration of dopamine synthesis from [14C]tyrosine

1971 • 42 citations

Attenuation of Postganglionic Sympathetic Nerve Activity by L-Dopa

1970 • 41 citations

Fine-structure of the rat's intercolumnar tubercle and its adjacent ependyma and choroid plexus, with especial reference to the appearance of its sinusoidal vessels in experimental argyria

1968 • 40 citations

Dyskinetic phenomena caused by the intrastriatal injection of phenylethylamine, phenylpiperazine, tetrahydroisoquinoline and tetrahydronaphthalene derivatives in the guinea pig

1975 • 40 citations

CENTRAL EMETIC ACTION AND TOXIC EFFECTS OF DIGITALIS IN CATS.

1965 • 40 citations

Is There an Interaction between Dopamine and Noradrenaline Containing Neurons in the Brain?

1970 • 40 citations

Effects of dopaminergic drugs and acute medial forebrain bundle lesions on striatal acetylcholine levels

1975 • 40 citations

The preferred conformation of dopamine from molecular orbital theory.

1970 • 40 citations

Central actions of 6-hydroxydopamine and other phenylethylamine derivatives on body temperature in the rat.

1972 • 40 citations

Apomorphine antagonism of the elevation of homovanillic acid induced by antipsychotic drugs

1972 • 39 citations

Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in parkinsonism

1976 • 38 citations

Apomorphine: Facilitation of sexual behaviour in female rats

1975 • 38 citations

Antiemetic Effectiveness of Haloperidol in Human Volunteers Challenged With Apomorphine

1971 • 38 citations

Comparative studies of emesis in pigeons and dogs.

1957 • 38 citations

Centrally acting emetics. II. Norapomorphine and derivatives

1968 • 38 citations

Effets de l�sions du septum, de l'amygdale, du striatum, de la substantia nigra et de l'ablation des bulbes olfactifs sur le comportement d'agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1973 • 38 citations

Dopamine receptor site sensitivity in hyperthyroid guinea pigs: A possible model of hyperthyroid chorea

1973 • 37 citations

Tremor Inhibition in Parkinson Syndrome After Apomorphine Administration Under L-Dopa and Decarboxylase-Inhibitor Basic Therapy

1972 • 37 citations

A Manual of Pharmacology and Its Application to Therapeutics and Toxicology

1948 • 36 citations

EFFECTS OF LOW DOSES OF A DOPAMINE-RECEPTOR STIMULATOR IN MANIA

1976 • 35 citations

On the dopaminergic nature of the gnawing compulsion induced by apomorphine in mice

1970 • 35 citations

Effect of l-DOPA on brain acetylcholine and choline in rats

1973 • 34 citations

Potentiation of Apomorphine Effect (Compulsive Gnawing Behaviour) in Mice

1967 • 34 citations

LSD and dopamine-sensitive adenylate-cyclase in various rat brain areas

1975 • 34 citations

Hypotensive effects of apomorphine in anesthetized cats

1971 • 34 citations

Dopamine agonist and antagonist activities of piribedil (ET495) and its metabolites

1974 • 33 citations

A NOTE ON APOMORPHINE AS A SEDATIVE

1945 • 33 citations

INFLUENCE OF CHLORPROMAZINE AND PROMETHAZINE ON VOMITING INDUCED WITH APOMORPHINE IN MAN

1954 • 33 citations

Rat mammary cancer inhibition by a prolactin suppressor, 2-bromo-α-ergokryptine (CB 154)

1971 • 33 citations

Aporphines. 9. Synthesis and Pharmacological Evaluation of (±) 9, 10-Dihydroxyaporphine [(±)-Isoapomorphine], (±)-,(-)-, and (±)-1,2-Dihydroxyaporphine, and (+)-1, 2, 9, 10 - Tetrahydroxyaporphine.

1973 • 33 citations

O-methylation of apomorphine and the metabolic prolongation of apomorphine-induced stereotyped behaviour

1973 • 32 citations

Biochemical and behavioral antagonism between fenfluramine and apomorphine in rats

1974 • 32 citations

Spectrofluorometric Assay of Apomorphine in Brain Tissue

1971 • 32 citations

Structural effects in drug distribution: comparative pharmacokinetics of apomorphine analogues

1974 • 32 citations

Prevention of<scp>l</scp>-Dopa-Induced Growth Hormone Stimulation by Hyperglycemia

1973 • 32 citations

Comparison between the effects of apomorphine and amphetamine on operant behavior

1972 • 31 citations

The effects of reserpine on uptake of epinephrine in brain and certain areas outside the blood-brain barrier.

1962 • 31 citations

Effect of clonidine on cardiac acceleration in vagotomized dogs

1973 • 30 citations

Apomorphine and its dopamine-like action

1972 • 30 citations

Development of tolerance in rats to the hypothermic effects of d-amphetamine and apomorphine

1974 • 30 citations

Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice

1974 • 30 citations

Synthesis and biological activity of some aporphine derivatives related to apomorphine

1974 • 30 citations

Effects of morphine and chlorpromazine on apomorphine-induced stereotyped behaviour

1974 • 29 citations

The absence of blood-brain barrier from certain areas of the central nervous system.

1961 • 29 citations

The Apomorphine Antagonism Test in Dogs

1971 • 29 citations

Aporphines V: Total Synthesis of (±)-Apomorphine

1970 • 29 citations

The influence of caffeine on d-amphetamine- and apomorphine-induced stereotyped behavior

1974 • 29 citations

Effects of apomorphine on exploration

1972 • 29 citations

On the dopamine-like action of apomorphine

1971 • 29 citations

The cardiovascular effects of apomorphine in the anaesthetized rat

1973 • 29 citations

Evidence for the methylation of apomorphine by catechol-O-methyl-transferase in vivo and in vitro

1973 • 28 citations

Induction and Inhibition of In Vivo Glucuronidation of Apomorphine in Mice

1971 • 27 citations

Apomorphine-induced accumulation of cyclic amp in isolated retinas of the rabbit

1974 • 26 citations

Changes in body core and skin temperature following intracerebroventricular injection of substances in the conscious rat: interpretation of data

1972 • 26 citations

Effects of apomorphine on self-stimulation

1973 • 26 citations

Effects of piribedil on noradrenaline and MOPEG-SO4 levels in the rat brain

1974 • 25 citations

Biological Disposition of Apomorphine IV. Isolation and Characterization of “Bound” Apomorphine

1961 • 24 citations

Effects of amantadine and 1-Dopa on apomorphine- and d-amphetamine-induced stereotyped behaviour in rats

1973 • 24 citations

Aphrodisiac effect ofl-DOPA and apomorphine in male sexually sluggish rats

1974 • 24 citations

Studies on the pharmacology of N-allylnormorphine.

1954 • 24 citations

Influence de l'isolement sur le comportement d' agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1971 • 23 citations

The influence of single and chronic morphine administration on some central effects of amphetamine and apomorphine

1970 • 23 citations

Effects of apomorphine on free-operant avoidance behavior in the rat

1968 • 23 citations

BLOCKADE BY APOMORPHINE OF HALOPERIDOL-INDUCED DYSKINESIA IN SCHIZOPHRENIC PATIENTS

1972 • 23 citations

Some Kinetic and Thermodynamic Characteristics of Apomorphine Degradation

1965 • 23 citations

Antagonistic effects of neuroleptics and apomorphine on synaptosomal tyrosine hydroxylase in vitro

1974 • 23 citations

Human renin inhibition by a diazoacyl reagent: Relationship of the enzyme to other proteinases

1975 • 23 citations

INHIBITION BY APOMORPHINE OF DOPAMINE DEAMINATION IN THE RAT BRAIN

1974 • 23 citations

Testicular Endocrine Function in a Pubertal Boy with 3β-Hydroxysteroid Dehydrogenase Deficiency

1974 • 23 citations

Catecholamines and The Control of Prolactin Secretion in Humans

1973 • 22 citations

Thermotropic activity of apomorphine in the rabbit: a central site of action

1975 • 22 citations

SOME OBSERVATIONS ON PECKING IN PIGEONS

1961 • 21 citations

Antagonism of 2-Br-α-ergokryptine-methanesulfonate (CB 154) to certain endocrine actions of centrally active drugs

1972 • 21 citations

In Vitro Metabolism of Certain Nornuciferine Derivatives

1971 • 21 citations

SUCCESSFUL OVULATION AND PREGNANCY ACHIEVED BY CB-154 (2-Br-α-ergocryptine) IN A WOMAN WITH CHIARI-FROMMEL SYNDROME¹

1974 • 20 citations

Effect of piribedil and one of its metabolites on the concentration of homovanillic acid in the rat brain

1974 • 20 citations

The effect of blocking dopamine release on synthesis rate of dopamine in the striatum of the rat

1975 • 20 citations

Apomorphine: Modification of Its Hyperthermic Effect in Rabbits by p -Chlorophenylalanine

1974 • 20 citations

On apomorphine and dopamine receptors

1972 • 20 citations

Cerebral phosphodiesterase and the dopamine receptor

1973 • 19 citations

Effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys

1975 • 19 citations

Emetic Responses of Monkeys to Apomorphine, Hydergine, Deslanoside and Protoveratrine.

1962 • 19 citations

Amines c�r�brales et comportement d'agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1974 • 19 citations

Auto-oxidation of Apomorphine

1961 • 18 citations

Emesis in birds.

1966 • 18 citations

Accelerated synthesis of dopamine in the rat brain after methadone

1972 • 18 citations

Dual mechanism of anti-emetic action of 10(gamma-dimethylaminopropyl)-2-chlorophenothiazine hydrochloride (chlorpromazine) in dogs.

1955 • 18 citations

Loss of Biological Activity of Apomorphine from Auto-Oxidation

1963 • 18 citations

Bulbocapnine's ability to antagonize the adrenergic inhibitory action of dopamine and analogs

1975 • 17 citations

Effects of amantadine, amphetamine and apomorphine on the locomotor activity in rats

1973 • 17 citations

Die pharmakologischen Eigenschaften des reinen Apokodeins

1926 • 17 citations

Conversion of Apocodeine to Apomorphine and Norapomorphine in Rats

1974 • 17 citations

An analysis of methylphenidate induced gnawing in guinea pigs

1970 • 16 citations

Effets comparés du Piribédil et de trois de ses métabolites sur le système extrapyramidal du rat

1974 • 16 citations

Reactions to apomorphine and spiroperidol of rats with striatal lesions: The relevance of kind and size of the lesion

1974 • 15 citations

SERUM FSH RISE INDUCED BY CB-154 (2-Br-α-ergocryptine) IN POSTPARTUM WOMEN

1974 • 15 citations

The mechanism of antagonism between apomorphine and metoclopramide on unit discharges from nuclear structures in the brainstem of the cat

1968 • 14 citations

Effects of apomorphine in vitro on the uptake and release of catecholamines in crude synaptosomal preparations of rat striatum and hypothalamus

1975 • 14 citations

Evidence that in rats 1-benzyl- -methoxy-3-trifluoromethylphenethylamine (SK& F 1-39728) dissociates anorexia from central stimulation and actions on brain monoamine stores.

1972 • 14 citations

Amphetamine- and apomorphine-induced alteration of the behavior of rats submitted to a competitive situation in a straight runway

1973 • 13 citations

Effect of Perphenazine on the Secretion of Prolactin in Vivo and in Vitro

1973 • 13 citations

N-Allylnorapomorphine^1a

1965 • 12 citations

The effect of L-dopa on chronotropic responses to cardioaccelerator nerve stimulation in dogs.

1971 • 12 citations

Antagonism of Apomorphine by Chlorinated Phenothiazines

1961 • 12 citations

THE HALOGENO-MORPHIDES AND -CODIDES, AND THE MECHANISM OF THE MORPHINE-APOMORPHINE TRANSFORMATION¹

1940 • 11 citations

Comparative effects of apomorphine, piribedil and other neurotropic agents on central analgesic-induced catatonia in the rat

1974 • 10 citations

Antiemetics in the Pigeon**College of Pharmacy, Ohio State University, Columbus 10

1957 • 9 citations

Analysis of apomorphine and norapomorphine in urine by thin-layer chromatographic fluorescence quenching

1973 • 9 citations

APOMORPHINE IN DYSTONIA MUSCULORUM DEFORMANS

1973 • 8 citations

Blockade of apomorphine pecking with phenothiazines

1965 • 8 citations

Note on the Characteristics of an Apomorphine Response in Pigeons**Received November 13, 1959, from the College of Pharmacy, University of Illinois, Chicago.

1960 • 8 citations

APOMORPHINE IN THE TREATMENT OF ADDICTION TO “OTHER DRUGS”*

1953 • 8 citations

The influence of piribedil (ET495) on components of locomotor activity

1975 • 7 citations

Functional Development of the Central Emetic Mechanism in the Puppy Dog

1971 • 7 citations

MODE OF ACTION OF CHLORPROMAZINE ON UNIT DISCHARGES FROM NUCLEAR STRUCTURES IN THE BRAINSTEM OF CATS

1970 • 7 citations

Influence de la surr�nalectomie, de l'hypophysectomie, de la thyroidectomie, de la castration ainsi que de la testost�rone sur le comportement d'agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1972 • 6 citations

Treatment of Sydenham's chorea with a combination of l-Dopa and a peripheral Dopa decarboxylase inhibitor

1975 • 5 citations

Biogenic Amines in the Hypothalamus: Effect of L-DOPA on Human Growth Hormone Levels in Patients with Huntington's Chorea

1973 • 5 citations

New Method for Assaying Antiapomorphine Activity in Pigeons

1970 • 4 citations

[METOCLOPRAMIDE AND THE APOMORPHINE TEST IN THE RAT].

1964 • 4 citations

Effects of 2-BR-α-ergokryptine (CB 154) on sex-linked rejection of pituitary isografts in female C57BL mice

1973 • 3 citations

On the anti-apomorphine effect of fenfluramine

1974 • 3 citations

The effect of β-phenethylamine on noradrenaline and dopamine turnover in rat brain

1974 • 3 citations

THE TREATMENT OF HOMOSEXUALITY AND ASSOCIATED PERVERSIONS BY PSYCHOTHERAPY AND AVERSION THERAPY

1967 • 2 citations