The Intestinal Microflora and tbe Colon Cancer Connection

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

1975 • 2,207 citations

Epidemiology of cancer of the colon and rectum

1971 • 1,360 citations

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

1974 • 1,066 citations

Dietary fibre, transit-time, faecal bacteria, steroids, and colon cancer in two Scandinavian populations. Report from the International Agency for Research on Cancer Intestinal Microecology Group.

1977 • 685 citations

BACTERIA AND qTIOLOGY OF CANCER OF LARGE BOWEL

1971 • 641 citations

Studies on the Intestinal Flora

1969 • 568 citations

Effect of diet on human fecal flora: comparison of Japanese and American diets

1974 • 518 citations

Large-Bowel Cancer in Hawaiian Japanese2

1973 • 492 citations

Metabolism of foreign compounds by gastrointestinal microorganisms.

1973 • 483 citations

Environmental Factors and Cancer of the Colon and Breast

1973 • 448 citations

Mutagen testing using TRP+ reversion in Escherichia coli

1976 • 439 citations

Large-Bowel Carcinogenesis: Fecal Constituents of Populations With Diverse Incidence Rates of Colon Cancer2

1973 • 413 citations

Human intestinal flora

1976 • 390 citations

The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1

2015 • 349 citations

The Relationship Between Diet and Rat Fecal Bacterial Enzymes Implicated in Colon Cancer 2 3

1976 • 338 citations

Studies of Intestinal Microflora

1967 • 331 citations

Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.

1973 • 328 citations

Intestinal Bacteria And The Hydrolysis Of Glycosidic Bonds

1971 • 320 citations

A review of the genotoxicity of food, drug and cosmetic colours and other azo, triphenylmethane and xanthene dyes

1982 • 318 citations

The significance of azo-reduction in the mutagenesis and carcinogenesis of azo dyes

1983 • 306 citations

The human intestinal microflora

1986 • 290 citations

Studies of Intestinal Microflora

1967 • 289 citations

Effect of Diet and Lactobacillus acidophilus Supplements on Human Fecal Bacterial Enzymes23

1980 • 285 citations

A CASE-CONTROL STUDY OF RELATIONSHIPS OF DIET AND OTHER TRAITS TO COLORECTAL CANCER IN AMERICAN BLACKS1

1979 • 278 citations

Selektive Erzeugung von Darmkrebs bei Ratten durch 1,2-Dimethyl-hydrazin

1967 • 273 citations

Nutrition and its Relationship to Cancer

1980 • 256 citations

The geographical distribution of cancer.

1969 • 253 citations

Low-Fiber Intake as an Etiologic Factor in Cancer of the Colon 2

1975 • 251 citations

Effect of Lactobacillus acidophilus Dietary Supplements on 1,2-Dimethylhydrazine Dihydrochloride-Induced Intestinal Cancer in Rats23

1980 • 240 citations

Colon carcinogens: Their metabolism and mode of action

1971 • 234 citations

Carcinogenic Properties of Nuts From <italic>Cycas Circinalis</italic> L. Indigenous to Guam<xref ref-type="fn" rid="FN2">2</xref>

1963 • 227 citations

Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function

1964 • 207 citations

Epidemiological correlations between diet and cancer frequency.

1981 • 200 citations

Fecal microbial flora in Seventh Day Adventist populations and control subjects

1977 • 185 citations

Discussion of Current Bacteriological Investigations of the Relationships between Instestinal Flora, Diet, and Colon Cancer

1975 • 176 citations

Alterations in fecal microflora enzymes related to diet, age, lactobacillus supplements, and dimethylhydrazine

1977 • 167 citations

Fecal Bacterial β-Glucuronidase: Control by Diet

1974 • 162 citations

Bacterial Content of Healthy Small Intestine

1953 • 142 citations

The normal colonic bacterial flora.

1975 • 137 citations

Toxicology of cycasin.

1968 • 132 citations

TREATMENT OF HEPATIC ENCEPHALOPATHY BY ALTERATION OF INTESTINAL FLORA WITH LACTOBACILLUS ACIDOPHILUS

1965 • 131 citations

Bile acid induction specificity of 7α-dehydroxylase activity in an intestinal Eubacterium species

1980 • 118 citations

The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone

1965 • 115 citations

The absorption, fate and excretion in rats of the water-soluble azo dyes, FD&C Red No. 2, FD&C Red No. 4, and FD&C Yellow No. 6.

1962 • 111 citations

Effect of beta-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats.

1982 • 111 citations

CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS.

1964 • 105 citations

Tumor Induction in Germfree Rats With Methylazoxymethanol (MAM) and Synthetic MAM Acetate<xref ref-type="fn" rid="FN1">2</xref>

1967 • 103 citations

Mutagens in the feces of 3 South-African populations at different levels of risk for colon cancer

1979 • 103 citations

Structure elucidation of a potent mutagen from human feces

1982 • 101 citations

Metabolic epidemiology of colon cancer: enzymic activity of fecal flora

1976 • 100 citations

Metabolic epidemiology of large bowel cancer Fecal mutagens in high- and low-risk population for colon cancer A preliminary report

1980 • 99 citations

The influence of a diet rich in wheat fibre on the human faecal flora

1976 • 99 citations

Structures of fecapentaenes, the mutagens of bacterial origin isolated from human feces

1983 • 93 citations

Diet and Colon Cancer: Assessment of Risk by Fiber Type and Food Source

1988 • 92 citations

Azo reduction of trypan blue to a known carcinogen by a cell-free extract of a human intestinal anaerobe

1978 • 91 citations

Lactobacillus acidophilus (Enpac) in Treatment of Hepatic Encephalopathy

1966 • 90 citations

Effects of differing purified cellulose, pectin, and hemicellulose fiber diets on fecal enzymes in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

1986 • 87 citations

Colonic-rectal cancer: fiber and other dietary factors

1978 • 84 citations

Fecal bile acids in two Japanese populations with different colon cancer risks.

1979 • 74 citations

Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects, and bowel cancer patients

1978 • 72 citations

Effects of a high-beef diet on bowel flora: a preliminary report

1974 • 72 citations

The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans☆

1983 • 65 citations

Mutagens in feces from vegetarians and non-vegetarians

1981 • 64 citations

Metabolism of the carcinogen N-hydroxy-N-2-fluorenylacetamide in germ-free rats

1970 • 63 citations

Fecal profiles of anaerobic microflora of large bowel cancer patients and patients with nonhereditary large bowel polyps.

1978 • 63 citations

METABOLIC FATE OF FOOD COLORANTS

1981 • 61 citations

The relationship between nitro group reduction and the intestinal microflora.

1975 • 58 citations

CHEMICALS As Causes Of CANCER

1966 • 54 citations

Influence of diet and age on fecal bacterial enzymes

1978 • 52 citations

In vitro production of human fecal mutagen

1980 • 44 citations

Stimulation of mutagen production in human feces by bile and bile acids

1982 • 42 citations

Effect of Antibiotics on Incidence of Rat Intestinal Tumors Induced by 1,2-Dimethylhydrazine Dihydrochloride<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 40 citations

Effect of Intestinal Microflora on 3,2′-Dimethyl-4-aminobiphenyl-Induced Carcinogenesis in F344 Rats2

1978 • 39 citations

Risk factors from geographic epidemiology for gastrointestinal cancer.

1982 • 39 citations

Production of Intestinal Mutagens

1983 • 38 citations

Conversion of Congo red and 2-azoxyfluorene to mutagens following in vitro reduction by whole-cell rat cecal bacteria

1983 • 36 citations

Effects of diet on the fecal excretion and bacterial modification of acidic and neutral steroids, and implications for colon carcinogenesis.

1981 • 35 citations

Production of a mutagen from ponceau 3R by a human intestinal anaerobe

1979 • 34 citations

Bile Acid Transformation by the Intestinal Flora and Cholesterol Saturation in Bile

1982 • 33 citations

Aromatisation of quinic acid and shikimic acid by bacteria and the production of urinary hippurate

1965 • 32 citations

Metabolism of the carcinogen N-2-Fluorenylacetamide in germ-free and conventional rats

1970 • 29 citations

Metabolic activation of DMH by colonic microsomes: A process influenced by type of dietary fat

1982 • 28 citations

Mutagenicity of different fractions of extract of human feces

1983 • 26 citations

Effect of oral lactobacillus feedings on fecal lacto bacillus counts

1972 • 24 citations

Fecal factors which modify the formation of fecal co-mutagens in high- and low-risk population for colon cancer

1980 • 23 citations

Mutagenic activation of biliary metabolites of 1-nitropyrene by intestinal microflora

1985 • 20 citations

Carcinogenic chemicals in food as an environmental health issue.

1974 • 19 citations

Influence of high dietary cellulose on fecal glycosidases in experimental rat colon carcinogenesis.

1984 • 17 citations

DNA‐damaging activity in ethanol‐soluble fractions of feces from New Zealand groups at varying risks of colorectal cancer

1985 • 13 citations