Tuberculosis—Immunopathogenesis and Therapy

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection

1989 • 1,587 citations

Tuberculosis in Patients with Human Immunodeficiency Virus Infection

1999 • 1,483 citations

Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis

1991 • 996 citations

Anonymous Mycobacteria in Pulmonary Disease

1959 • 873 citations

Tuberculosis in Patients with Human Immunodeficiency Virus Infection

1991 • 849 citations

Polymerase Chain Reaction Amplification of a Repetitive DNA Sequence Specific for Mycobacterium tuberculosis

1990 • 763 citations

Controlled chemoprophylaxis trials in tuberculosis. A general review.

1970 • 714 citations

Resurgent Tuberculosis in New York City: Human Immunodeficiency Virus, Homelessness, and the Decline of Tuberculosis Control Programs

1991 • 670 citations

Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.

1990 • 544 citations

Efficacy of various duration of isoniazid preventive therapy for tuberculosis : five years follow-up in the IUAT trial

1982 • 518 citations

Treatment of Tuberculosis in Patients with Advanced Human Immunodeficiency Virus Infection

1991 • 486 citations

Stress proteins, infection, and immune surveillance

1989 • 477 citations

IS6110, an IS-like element ofMycobacterium tuberculosiscomplex

1990 • 441 citations

Insertion element IS986 from Mycobacterium tuberculosis: a useful tool for diagnosis and epidemiology of tuberculosis

1990 • 419 citations

Racial Differences in Susceptibility to Infection byMycobacterium tuberculosis

1990 • 407 citations

Extrapulmonary tuberculosis revisited: a review of experience at Boston City and other hospitals.

1984 • 386 citations

Isoniazid-Associated Hepatitis in 114 Patients

1975 • 372 citations

Detection ofMycobacterium tuberculosisin Sputum Samples Using a Polymerase Chain Reaction

1991 • 364 citations

Tuberculosis as an Endemic and Nosocomial Infection among the Elderly in Nursing Homes

1985 • 345 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Extrapulmonary Tuberculosis Revisited

1984 • 332 citations

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

1990 • 331 citations

Transmission of tubercle bacilli: The effects of chemotherapy

1976 • 305 citations

The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein

1988 • 297 citations

Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium tuberculosis

1970 • 289 citations

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

1987 • 287 citations

Exogenous Reinfection with Tuberculosis in a Shelter for the Homeless

1986 • 272 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Evaluation of rapid radiometric method for drug susceptibility testing of Mycobacterium tuberculosis

1981 • 247 citations

A 62-Dose, 6-Month Therapy for Pulmonary and Extrapulmonary Tuberculosis

1990 • 240 citations

Isoniazid-Associated Hepatitis

1972 • 239 citations

Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages

1987 • 239 citations

Present aspects of bacterial resistance in tuberculosis.

1965 • 214 citations

Clinical and roentgenographic spectrum of pulmonary tuberculosis in the adult

1977 • 208 citations

Frequency of Negative Intermediate-Strength Tuberculin Sensitivity in Patients with Active Tuberculosis

1971 • 196 citations

The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.

1988 • 189 citations

Characterization of a Mycobacterium tuberculosis insertion sequence belonging to the IS3 family

1990 • 188 citations

L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.

1991 • 180 citations

T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis

1991 • 174 citations

Extrapulmonary tuberculosis. Experience of a community hospital and review of the literature

1985 • 172 citations

Increased Mortality and Tuberculosis Treatment Failure Rate among Human Immunodeficiency Virus (HIV) Seropositive Compared with HIV Seronegative Patients with Pulmonary Tuberculosis Treated with “Standard” Chemotherapy in Kinshasa, Zaire

1991 • 169 citations

Enumeration of Tubercle Bacilli in Sputum of Patients with Pulmonary Tuberculosis

1973 • 167 citations

Serum Transaminase Elevations and Other Hepatic Abnormalities in Patients Receiving Isoniazid

1969 • 156 citations

Human immune response to Mycobacterium tuberculosis antigens

1991 • 155 citations

Controlled Trial of 2, 4, and 6 Months of Pyrazinamide in 6-Month, Three-Times-Weekly Regimens for Smear-positive Pulmonary Tuberculosis, Including an Assessment of a Combined Preparation of Isoniazid, Rifampin, and Pyrazinamide: Results at 30 Months

1991 • 154 citations

Experimental Short-course Preventive Therapy of Tuberculosis with Rifampin and Pyrazinamide

1989 • 149 citations

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens.

1986 • 146 citations

MOLECULAR BIOLOGY OF THE MYCOBACTERIA

1989 • 145 citations

Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium tuberculosis

1970 • 141 citations

Mycobacterial diseases

1990 • 141 citations

Rapid identification of Mycobacterium avium complex in culture using DNA probes

1987 • 137 citations

Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate

1990 • 136 citations

Structure of Mycobacteria: Recent Developments in Defining Cell Wall Carbohydrates and Proteins

1989 • 135 citations

Preventive Therapy With Isoniazid

1986 • 134 citations

Five-Year Follow-Up of a Controlled Trial of Five 6-Month Regimens of Chemotherapy for Pulmonary Tuberculosis

1987 • 119 citations

A Retrospective Cohort Study of the Risk of Tuberculosis Among Women of Childbearing Age with HIV Infection in Zaire

1991 • 114 citations

Occupational Tuberculous Infections among Pulmonary Physicians in Training

1990 • 113 citations

Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages

1988 • 110 citations

Human alveolar macrophages: HLA-DR-positive macrophages that are poor stimulators of a primary mixed leukocyte reaction.

1986 • 108 citations

Airborne Contagion and Air Hygiene

1955 • 103 citations

The Epidemiology of Tuberculosis in Physicians

1979 • 101 citations

An Outbreak of Tuberculosis in a Shelter for Homeless Men: A Description of Its Evolution and Control

1991 • 99 citations

The Rising Age of the Tuberculosis Patient: A Sign of Success and Failure

1980 • 98 citations

Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes.

1987 • 95 citations

The competing risks of tuberculosis and hepatitis for adult tuberculin reactors.

1975 • 92 citations

Rapid identification using a specific DNA probe of Mycobacterium avium complex from patients with acquired immunodeficiency syndrome

1987 • 90 citations

A Mouse Model of the Recrudescence of Latent Tuberculosis in the Elderly

1988 • 88 citations

Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis

1990 • 85 citations

Potential value of serology for diagnosis of extrapulmonary tuberculosis

1990 • 83 citations

What Animal Models Can Teach Us About the Pathogenesis of Tuberculosis in Humans

1989 • 76 citations

Relationships Among Mycobacteria and Nocardiae Based upon Deoxyribonucleic Acid Reassociation

1973 • 72 citations

The use of isoniazid among household contacts of open cases of pulmonary tuberculosis.

1965 • 67 citations

Tuberculosis in House Staff: A Decision Analysis Comparing the Tuberculin Screening Strategy with the BCG Vaccination

1991 • 64 citations

Rapid drug-susceptibility testing of Mycobacterium tuberculosis.

1981 • 64 citations

Infectivity of sputum-positive tuberculous patients on chemotherapy.

1974 • 63 citations

Tuberculosis in Correctional Institutions

1989 • 63 citations

THE IMMUNOLOGY OF TUBERCULOSIS

1980 • 56 citations

Gamma/Delta T-Lymphocytes Are Not Increased in Number in Granulomatous Lesions of Patients with Tuberculosis or Sarcoidosis

1991 • 53 citations

Aerial transmission of mycobacteria.

1969 • 50 citations

Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: identification of an M. leprae-specific repetitive sequence

1989 • 50 citations

Five-Year Follow-Up of a Clinical Trial of Three 6-Month Regimens of Chemotherapy Given Intermittently in the Continuation Phase in the Treatment of Pulmonary Tuberculosis

1988 • 48 citations

A Review of the Methods of Identification and Differentiation of Mycobacteria

1981 • 48 citations

Genetic Control of Susceptibility to Mycobacterial Infections

1989 • 47 citations

In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis

1987 • 47 citations

Assessment of a Daily Combined Preparation of Isoniazid, Rifampin, and Pyrazinamide in a Controlled Trial of Three 6-Month Regimens for Smear-positive Pulmonary Tuberculosis

1991 • 47 citations

Drug-resistant Tuberculosis in an Urban Population Including Patients at Risk for Human Immunodeficiency Virus Infection

1992 • 45 citations

Tuberculosis in physicians. Compliance with preventive measures.

1987 • 42 citations

Respiratory Defense Mechanisms. Part II.

1978 • 42 citations

A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus

1990 • 42 citations

Risk of Tuberculous Infection Among House Staff in an Urban Teaching Hospital

1985 • 41 citations

Time Course and Boosting of Tuberculin Reactions in Nursing Home Residents^1–4

1986 • 38 citations

The spectrum of tuberculosis as currently seen in a metropolitan hospital.

1973 • 36 citations

Pulmonary tuberculosis in residents of lodging houses, night shelters and common hostels in Glasgow: A 5-year prospective survey

1985 • 36 citations

Techniques of DNA hybridization detect small numbers of mycobacteria with no cross-hybridization with non-mycobacterial respiratory organisms.

1985 • 33 citations

Histochemical studies relating the activation of macrophages to the intracellular destruction of tubercle bacilli.

1977 • 32 citations

Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice

1991 • 31 citations

[Epidemiology of tuberculosis].

1985 • 29 citations

Chemoprophylaxis in inactive tuberculosis: long-term evaluation of a Canadian trial.

1976 • 28 citations

Respiratory Infections.

1986 • 24 citations

Evaluation of the Potential Role of Serodiagnosis of Tuberculosis in a Clinic in Bolivia by Decision Analysis

1991 • 19 citations

Effect of isoniazid upon the reactivation of inactive tuberculosis. Preliminary report.

1962 • 18 citations

Effect of Isoniazid upon the Reactivation of Inactive Tuberculosis¹

1965 • 16 citations

A Cloned DNA Fragment for Identification of Mycobacterium tuberculosis

1989 • 16 citations

ELISA Analysis of BACTEC® Bottles for the Earlier Diagnosis of Tuberculosis

1989 • 13 citations

The Use of Sputum Cultures in the Evaluation of Immigrants Classified as Tuberculosis Suspects

1989 • 10 citations

Host-Parasite Relationships in Experimental Airborne Tuberculosis

2015 • 8 citations