Trypanosoma cruzi Affects Nitric Oxide Production by Murine Peritoneal Macrophages

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism inhibitable by interleukin‐10 and transforming growth factor‐β

1992 • 437 citations

Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells.

1976 • 309 citations

Synergism between tumor necrosis factor‐α and interferon‐γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide‐dependent mechanism

1992 • 290 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Immunosuppression induced by nitric oxide and its inhibition by interleukin‐4

1992 • 172 citations

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

1992 • 136 citations

Trypanosoma cruzi: Cytokine effects on macrophage trypanocidal activity

1991 • 73 citations

Selective binding of Trypanosoma cruzi to host cell membrane polypeptides

1990 • 24 citations