Biogenic Amines and Depression

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Biogenic Amines and Emotion

1967 • 878 citations

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

1969 • 645 citations

Inhibition of Uptake of Tritiated-noradrenaline in the Intact Rat Brain by Imipramine and Structurally Related Compounds

1964 • 506 citations

Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.

1969 • 445 citations

Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,α-dimethyl-meta-tyramine

1969 • 417 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

Metabolism of normetanephrine-H3 in rat brain—identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite

1968 • 368 citations

Catecholamine Metabolism, Depressive Illness, and Drug Response

1972 • 341 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine.

1966 • 307 citations

Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients

1975 • 269 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

METABOLISM OF [³H]NOREPINEPHRINE IN THE RAT BRAIN

1965 • 263 citations

Stimulation and destruction of the locus coeruleus: Opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex

1973 • 258 citations

Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients

1971 • 257 citations

Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents

1967 • 252 citations

Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline

1973 • 242 citations

In vivo studies of the metabolism of norepinephrine in the central nervous system.

1968 • 228 citations

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

1975 • 224 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro.

1967 • 215 citations

3-Methoxy-4-Hydroxy Phenylglycol (MHPG) Excretion in Depressive States

1968 • 208 citations

Norepinephrine Metabolites as Biochemical Criteria for Classifying Depressive Disorders and Predicting Responses to Treatment: Preliminary Findings

1973 • 204 citations

L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.

1970 • 181 citations

THE METABOLISM OF [C¹⁴]NORADRENALINE BY CAT BRAIN IN VIVO*

1963 • 166 citations

Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid

1973 • 156 citations

Raphe neurons: effect of tricyclic antidepressant drugs

1972 • 152 citations

Depression and MHPG Excretion

1972 • 150 citations

A CLINICAL AND BIOCHEMICAL STUDY OF A TRIAL OF IPRONIAZID IN THE TREATMENT OF DEPRESSION

1959 • 149 citations

Plasma Levels of Imipramine and Desmethylimipramine during Therapy

1967 • 137 citations

A specific gas-chromatographic method for the measurement of “steady-state” plasma levels of amitriptyline and nortriptyline in patients

1971 • 125 citations

THE UPTAKE OF CIRCULATING [³H]NOREPINEPHRINE BY THE PITUITARY GLAND AND VARIOUS AREAS OF THE BRAIN

1961 • 120 citations

Urinary Catecholamine Metabolites during Behavioral Changes in a Patient with Manic-Depressive Cycles

1973 • 118 citations

Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain

1970 • 115 citations

Diagnostic subgroups of affective disorders and their urinary excretion of catecholamine metabolities

1975 • 112 citations

Amine Precursors and Depression

1975 • 110 citations

Excretion of catecholamine metabolites following intraventricular injection of 6-hydroxydopamine in the Macaca speciosa

1973 • 108 citations

Glycol metabolites of noradrenaline in brain tissue

1969 • 82 citations

Effect of Drugs on Amines in the CNS

1971 • 82 citations

MHPG Excretion in Depressive Disorders: Relation to Clinical Subtypes and Desynchronized Sleep

1973 • 82 citations

Cerebrospinal Fluid MHPG

1973 • 81 citations

Clinical experience with dihydroxyphenylalanine (DOPA) in depression

1963 • 79 citations

INCREASE OF NORADRENALINE METABOLISM FOLLOWING ELECTRICAL STIMULATION OF THE LOCUS COERULEUS IN THE RAT¹

1973 • 79 citations

Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways

1973 • 78 citations

ACCUMULATION AND DISAPPEARANCE OF NORADRENALINE AND ITS MAJOR METABOLITES SYNTHESIZED FROM INTRAVENTRICULARLY INJECTED [³H]DOPAMINE IN THE RAT BRAIN

1974 • 73 citations

Dextroamphetamine Response as a Possible Predictor of Improvement With Tricyclic Therapy in Depression

1971 • 72 citations

Effect of tricyclic antidepressants on the uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices incubated in buffer or human plasma

1973 • 71 citations

3-Methoxy-4-hydroxyphenylglycol in depression

1973 • 67 citations

The metabolism of circulating norepinephrine by human subjects.

1971 • 67 citations

Catecholamine Metabolism, Depression and Stress

1971 • 65 citations

Effects of tricyclic antidepressants on the uptake and metabolism of intracisternally administered norepinephrine-H3 in rat brain

1969 • 63 citations

The Stress of Aircraft Carrier Landings

1970 • 63 citations

Quantitative in Vitro Studies on Noradrenaline Uptake and its Inhibition by Amphetamine, Desipramine and Chlorpromazine

1967 • 56 citations

Mass fragmentographic determination of 4-hydroxy-3-methoxymndelic acid in human urine, cerebrospinal fluid, brain and serum using a deuterium-labelled internal standard

1975 • 53 citations

Serotonin Metabolism in Depression: Clinical Application of the Probenecid Test1

1974 • 48 citations

Estimation of the contribution of peripheral and central noradrenergic neurones to urinary 3-methoxy-4-hydroxyphenylglycol in the rat

1974 • 44 citations

A Pharmacokinetic Approach to the Treatment of Depression

1972 • 43 citations

Relation of Exercise to MHPG Excretion in Normal Subjects

1973 • 43 citations

Uptake of [3H]5-hydroxytryptamine and [3H]noradrenaline by slices of rat brain incubated in plasma from patients treated with chlorimipramine, imipramine or amitriptyline

1973 • 34 citations

Modification by desipramine (DMI) of the availability of norepinephrine released by reserpine in the hypothalamus of the rat in vivo.

1969 • 34 citations

A Technique for Assaying the Kinetics of Norepinephrine Metabolism in the Central Nervous System in Vivo

1966 • 33 citations

CATECHOLAMINE METABOLISM IN THE DOG: COMPARISON OF INTRAVENOUSLY AND INTRAVENTRICULARLY ADMINISTERED [¹⁴C]DOPAMINE AND [³H]NOREPINEPHRINE

1971 • 32 citations

Cerebrospinal fluid levels of 3-methoxy4hydroxyphenylethylene glycol in Parkinsonism before and after treatment with L-DOPA

1971 • 26 citations

Collaborative psychopharmacologic studies exploring catecholamine metabolism in psychiatric disorders

1974 • 23 citations

Psychotropic drugs and dopamine uptake inhibition.

1975 • 21 citations

The effect of unilateral and bilateral lesions in the locus coeruleus on the levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in neocortex

1973 • 18 citations

An in vitro study of the effects of tricyclic antidepressant drugs on the accumulation of C14-serotonin by rabbit brain.

1969 • 13 citations

L-DOPA in the Treatment of Depressive Symptoms

1971 • 11 citations

Modification by a tricyclic series of compounds of the noradrenaline effect on the cat nictitating membrane

1971 • 10 citations

Catecholamine metabolism and affective disorders

1973 • 9 citations

Preliminary clinical experience with L-dopa in endogenous depressions.

1972 • 4 citations