Antagonists of H1 Receptors of Histamine: Recent Developments

Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy)-[1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties

1986 • 351 citations

Mianserin

1978 • 301 citations

Astemizole

1984 • 258 citations

The effects of the H1 and H2 antihistamines on "allergic" histamine release and its inhibition by histamine.

1975 • 233 citations

HETEROGENEITY OF HISTAMINE Hi‐RECEPTORS: SPECIES VARIATIONS IN [³H]MEPYRAMINE BINDING OF BRAIN MEMBRANES

1979 • 225 citations

The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.

1978 • 216 citations

Handbuch der experimentellen Pharmakologie

1936 • 209 citations

Importance of fundamental principles in drug evaluation

1968 • 196 citations

THE BINDING OF [³H]MEPYRAMINE TO HISTAMINE H₁ RECEPTORS IN GUINEA‐PIG BRAIN

1978 • 170 citations

Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle

1977 • 141 citations

[3H]Mianserin: differential labeling of serotonin and histamine receptors in rat brain.

1981 • 137 citations

Pharmacokinetics and biotransformation studies of terfenadine in man.

1982 • 125 citations

Performance studies with antihistamines.

1978 • 123 citations

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

1980 • 106 citations

Pizotifen (BC-105)

1972 • 105 citations

The relative antihistaminic and psychomotor effects of hydroxyzine and cetirizine

1987 • 104 citations

In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole.

1982 • 97 citations

Application of cyclodextrins to chiral analysis by ¹H NMR spectroscopy

1988 • 95 citations

Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents

1986 • 93 citations

Inhibitory activity of terfenadine on histamine-induced skin wheals in man

1977 • 91 citations

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

1985 • 89 citations

Histamine H1 receptors in human brain labelled with [3H]Doxepin

1984 • 84 citations

Some clinical pharmacological studies with terfenadine, a new antihistamine drug.

1978 • 81 citations

Novel type of substituted piperazine with high antiserotonin potency

1970 • 78 citations

Stereochemical aspects of antihistamine action. 4. Absolute configuration of carbinoxamine antipodes

1971 • 67 citations

A comparison of triprolidine and clemastine on histamine antagonism and performance tests in man: Implications for the mechanism of drug induced drowsiness

1975 • 63 citations

Antihistamines, drowsiness, and psychomotor impairment: central nervous system effect of cetirizine.

1987 • 62 citations

Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H₁‐receptor antagonist with negligible ability to penetrate the central nervous system

1986 • 61 citations

Effects of antidepressant drugs on histamine-H1 receptors in the brain

1984 • 60 citations

Histamine challenge and anterior nasal rhinometry: their use in the assessment of pseudoephedrine and triprolidine as nasal decongestants in subjects with hayfever.

1978 • 59 citations

Absolute configurations of the pheniramines, methyl phenidates, and pipradrols

1969 • 57 citations

Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues.

1973 • 57 citations

Bioavailability of terfenadine in man

1981 • 57 citations

[3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates

1981 • 56 citations

EFFECTS ON THE HUMAN CENTRAL NERVOUS SYSTEM OF TWO ISOMERS OF EPHEDRINE AND TRIPROLIDINE, AND THEIR INTERACTION

1974 • 53 citations

Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man.

1979 • 50 citations

Terfenadine, the first non-sedating antihistamine.

1982 • 50 citations

Oxatomide

1984 • 48 citations

Comparative pharmacology of chlorpheniramine (Chlor-Trimeton) and its optical isomers.

1958 • 48 citations

New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines

1985 • 47 citations

Synthese und absolute Konfiguration von Clemastin und seiner Isomeren

1976 • 47 citations

Pharmacology of the specific histamine H1-antagonist astemizole.

1983 • 46 citations

Levocabastine (R 50547): The prototype of a chemical series of compounds with specific H₁‐antihistaminic activity

1986 • 46 citations

High-affinity binding of [3H]doxepin to histamine H1-receptors in rat brain: Possible identification of a subclass of histamine H1-receptors

1982 • 45 citations

New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amines

1985 • 44 citations

Absence of an effect of terfenadine on guinea pig brain histamine H1-receptors in vivo determined by receptor binding techniques.

1982 • 43 citations

Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers.

1984 • 42 citations

Acute and subacute actions on human performance and interactions with diazepam of temelastine (SK & F 93944) and diphenhydramine

1986 • 42 citations

Evidence for tolerance to the central nervous effects of the histamine antagonist, triprolidine, in man

1977 • 41 citations

[Antiviral effect of aqueous plant extracts in tissue culture].

1978 • 40 citations

The relation between biological activity and the degree of resolution of optical isomers

1972 • 38 citations

Dose‐proportionality, bioavailability, and steady‐state kinetics of astemizole in man

1986 • 38 citations

Characterization of [3H]mepyramine binding to the longitudinal muscle of guinea pig small intestine.

1981 • 38 citations

A Double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis.

1975 • 37 citations

The binding of doxepin to histamine H₁‐preceptors in guinea‐pig and rat brain

1985 • 37 citations

The binding of conformationally restricted antihistamines to histamine receptors

1973 • 36 citations

[125I]iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain

1986 • 35 citations

Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis.

1986 • 33 citations

Excretion and biotransformation of astemizole in rats, guinea‐pigs, dogs, and man

1986 • 32 citations

Histamine II and Anti-Histaminics

1978 • 32 citations

Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl)piperidines and structurally related compounds

1989 • 29 citations

Oxatomide: Inhibition and stimulation of histamine release from human lung and leucocytes in vitro

1980 • 29 citations

Synthesis of terfenadine.

1982 • 29 citations

Pharmacodynamic and pharmacokinetics of BW 825C: A new antihistamine

1985 • 29 citations

Sensitive Assay for determination of Hydroxyzine in Plasma and its Human Pharmacokinetics

1979 • 25 citations

Triprolidine Radioimmunoassay: Disposition in Animals and Humans

1984 • 25 citations

Pharmacokinetics and tissue distribution of astemizole in the dog

1986 • 25 citations

Effect of mequitazine a non sedative antihistamine on brain H1 receptors

1981 • 24 citations

2 Histamine Receptors in the Mammalian Central Nervous System: Biochemical Studies

1987 • 23 citations

Protection of rats from compound 48/80-induced lethality. A simple test for inhibitors of mast cell-mediated shock.

1978 • 22 citations

(+)- and (-)-3-Methoxycyproheptadine. A comparative evaluation of the antiserotonin, antihistaminic, anticholinergic, and orexigenic properties with cyproheptadine

1977 • 22 citations

Neurotransmitter receptor binding and drug discovery

1983 • 22 citations

Separate binding sites for histaminic drugs in rat cerebral cortex

1980 • 21 citations

Effects of azatadine maleate on subjective appraisal and psychomotor functions relevant to driving performance

1979 • 21 citations

Terfenadine, safety and tolerance in controlled clinical trials.

1982 • 20 citations

Microbial Transformation of the Antihistaminic Drug Triprolidine Hydrochloride

1988 • 20 citations

Competitive and stereoselective histamine H1 antagonistic effect of cicletanide in guinea-pig isolated ileum

1987 • 19 citations

Determination of Triprolidine in Human Plasma by Quantitative TLC

1977 • 18 citations

Antihistamin-Substanzen XLVII. In p- und m-Stellung substituierte Mephenhydraminderivate

1959 • 16 citations

N-Benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties

1984 • 16 citations

Evidence for low brain penetration by the H1-receptor antagonist temelastine (SK & F 93944)

1987 • 15 citations

Radioimmunoassay procedures for astemizole and metabolites in plasma

1986 • 15 citations

Structure-Activity Relationships of H1-Receptor Antagonists

1978 • 15 citations

Studies on histaminergic compounds VIII. A new series of compounds showing H1-antagonistic and H2-agonistic properties; synthesis, in vitro pharmacology and structure—activity relationships

1987 • 14 citations

Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist

1987 • 13 citations

Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors

1987 • 13 citations

Resolution of Chlorpheniramine and the Pharmacological Properties of its Isomers

1959 • 13 citations

A Double-Blind Controlled Evaluation of Actifed® and its Individual Constituents in Allergic Rhinitis

1982 • 12 citations

Chemical development of astemizole‐like compounds

1986 • 12 citations

Gaschromatography of clemastine. A study of plasma kinetics and biological effect.

1978 • 9 citations

[Separation and physiologic activity of the two optic isomers of dimethylaminoethoxy-p-tolylphenylmethane].

1951 • 9 citations

5 Applications of Modern-High-Field NMR Spectroscopy in Medicinal Chemistry

1989 • 8 citations

Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products

1984 • 8 citations

The structure of phenindamine base and salts in the solute state

1988 • 7 citations

General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate. 1st communication: effects on the central nervous system.

1988 • 7 citations

Effect of Azatadine on Human Performance

1980 • 6 citations

Use of Calcium Channel Blocking Agents in the Management of Childhood Asthma

1984 • 6 citations

Pulmonary aerosol actions of LY188695 (KB2413), a new potent H1-receptor antagonist

1987 • 5 citations

Effect of azatadine on human performance.

1980 • 5 citations

No effects on sleep of a histamine H1‐receptor antagonist: temelastine.

1986 • 3 citations

[Initial therapeutic trials in ambulatory patients of a new barely tranquilizing antihistaminic].

1968 • 2 citations

The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions

1982 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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