Development of a novel, Ins(1,4,5)P3-specific binding assay: Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Untersuchungen uber die Harnstoffbildung im Tierkörper

1932 • 3,104 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Computer calculation of equilibrium concentrations in mixtures of metal ions and complexing species

1967 • 642 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.

1987 • 551 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils

1986 • 296 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Determination of the mitochondrial protonmotive force in isolated hepatocytes.

1980 • 263 citations

Use of Isolated Liver Cells and Kidney Tubules in Metabolic Studies

1976 • 252 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells

1986 • 190 citations

Intracellular receptors for inositol 1,4,5-trisphosphate in angiotensin II target tissues.

1987 • 169 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

1984 • 158 citations

Binding of inositol trisphosphate by a liver microsomal fraction

1986 • 145 citations

Binding sites for inositol trisphosphate in the bovine adrenal cortex

1985 • 145 citations

Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils.

1986 • 88 citations

Stereospecific recognition sites for [3H]inositol(1,4,5)-trisphosphate in particulate preparations of rat cerebellum

1987 • 87 citations

The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes

1986 • 70 citations

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

1987 • 66 citations

Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets

1987 • 52 citations

Inositol 1,2-cyclic 4,5-trisphosphate is not a product of μscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands

1987 • 52 citations

Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.

1987 • 45 citations

Bradykinin-induced changes in Inositol trisphosphate mass in MDCK cells

1986 • 37 citations

Metabolism of inositol 1,4,5-trisphosphate in guinea-pig hepatocytes

1987 • 35 citations

Chronic ethanol consumption reduces [3H]inositol (1,4,5) trisphosphate specific binding in mouse cerebellar membrane fragments

1987 • 27 citations

Determination of basal and stimulated levels of inositol triphosphate in [32P]orthophosphate-labeled platelets

1986 • 26 citations

Bradykinin-stimulated changes in inositol phosphate mass in renal papillary collecting tubule cells

1987 • 20 citations

Characterization of a rapid cellular-fractionation technique for hepatocytes. Application in the measurement of mitochondrial membrane potential in situ

1984 • 17 citations

Specific binding of [3H]inositol trisphosphate to rat cerebral cortical microsomal membranes

1987 • 4 citations