Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long- term repopulating stem cells

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Data analysis

1996 • 2,754 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

1993 • 949 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

1977 • 563 citations

Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma

1991 • 538 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Expression of Thy-1 on human hematopoietic progenitor cells.

1993 • 477 citations

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

1990 • 456 citations

CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

1968 • 441 citations

Comparison of haematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants.

1992 • 427 citations

Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells

1990 • 414 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Reconstitution of Hematopoiesis after High-Dose Chemotherapy by Autologous Progenitor Cells Generated ex Vivo

1995 • 382 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Defining a Therapeutic Dose of Peripheral Blood Stem Cells

1992 • 334 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL- 6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts

1996 • 326 citations

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure.

1982 • 295 citations

Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer

1996 • 184 citations

Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells

1994 • 181 citations

Two phases of engraftment established by serial bone marrow transplantation in mice

1989 • 179 citations

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

1992 • 178 citations

Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow.

1990 • 171 citations

Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential

1993 • 166 citations

Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells.

1992 • 160 citations

The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.

1991 • 157 citations

Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells

1995 • 146 citations

Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells.

1991 • 146 citations

Maintenance of transplantation potential in ex vivo expanded CD34(+)- selected human peripheral blood progenitor cells

1994 • 139 citations

Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells

1994 • 137 citations

Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro

1993 • 135 citations

Ex vivo expansion of hematopoietic stem and progenitor cells--robbing Peter to pay Paul? [editorial]

1993 • 129 citations

Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential.

1996 • 112 citations

Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability

1989 • 100 citations

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil- treated murine marrow

1993 • 97 citations

The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors.

1991 • 86 citations

Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor

1996 • 85 citations

Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics.

1992 • 71 citations

Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells

1996 • 63 citations

Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: differential activity of cultured bone marrow and enriched stem cell populations.

1994 • 58 citations

Use of 5-fluorouracil to analyze the effect of macrophage inflammatory protein-1 alpha on long-term reconstituting stem cells in vivo

1993 • 49 citations

Endotoxin-induced sensitivity of hematopoietic stem cells to chemotherapeutic agents.

1972 • 17 citations

Changes in expression of major histocompatibility complex (MHC) class-I antigen on hematopoietic progenitors during murine development.

1987 • 10 citations