The Non-Catalytic Role and Complex Management of Acetylcholinesterase in the Mammalian Brain Call for RNA-Based Therapies

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

1996 • 730 citations

Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response

1996 • 355 citations

Novel Functions of Cholinesterases in Development, Physiology and Disease

1994 • 253 citations

Cholinergic regulation of neurite outgrowth from isolated chick sympathetic neurons in culture

1995 • 150 citations

Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice

1995 • 134 citations

Genetic predisposition to adverse consequences of anti–cholinesterases in ‘atypical’ BCHE carriers

1995 • 113 citations

Human Cholinesterases and Anticholinesterases

1993 • 113 citations

Enhanced Hemicholinium Binding and Attenuated Dendrite Branching in Cognitively Impaired Acetylcholinesterase‐Transgenic Mice

1997 • 99 citations

Probing accessible sites for ribozymes on human acetylcholinesterase RNA.

1997 • 96 citations

The effect of acetylcholinesterase on outgrowth of dopaminergic neurons in organotypic slice culture of rat mid-brain

1995 • 82 citations

Differentiation Intensifies the Susceptibility of Pheochromocytoma Cells to Antisense Oligodeoxynucleotide-Dependent Suppression of Acetylcholinesterase Activity

1997 • 24 citations

Shifting patterns of cortical cholinesterases in Alzheimer's disease: implications for treatment, diagnosis, and pathogenesis.

1990 • 22 citations

Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis.

1996 • 17 citations

Pharmacokinetic studies of cholinesterase inhibitors

2009 • 16 citations

Antisense Oligodeoxynucleotide Dependent Suppression of Acetylcholinesterase Expression Reduces Process Extension from Primary Mammalian Neurons

1998 • 4 citations