Induction and Rejoining of DNA Single-Strand Breaks in Relation to Cellular Growth in Human Cells Exposed to Three Hydroperoxides at 0°C and 37°C

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

1988 • 1,505 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Molecular Pharmacology

1964 • 599 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues.

1982 • 490 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

1984 • 350 citations

DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells

1988 • 323 citations

Mammalian Cells Are Not Killed by DNA Single-Strand Breaks Caused by Hydroxyl Radicals from Hydrogen Peroxide

1985 • 305 citations

Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction.

1985 • 300 citations

tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1989 • 222 citations

Comparison of the effects of hydrogen peroxide and X-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79)

1981 • 163 citations

Free-radical generation by copper ions and hydrogen peroxide. Stimulation by Hepes buffer

1988 • 158 citations

Calcium chelator Quin 2 prevents hydrogen‐peroxide‐induced DNA breakage and cytotoxicity

1989 • 157 citations

Free radical involvement in the oxidate phenomena induced by tert-butyl hydroperoxide in erythrocytes

1983 • 153 citations

Detection of peroxyl and alkoyl radicals produced by reaction of hydroperoxides with heme-proteins by electron spin resonance spectroscopy

1988 • 150 citations

Hydrogen Peroxide-Induced Base Damage in Deoxyribonucleic Acid

1990 • 134 citations

DNA strand breaks in human leukocytes induced by superoxide anion, hydrogen peroxide and tumor promoters are repaired slowly compared to breaks induced by ionizing radiation

1986 • 123 citations

Spin trapping of the primary radical involved in the activation of the carcinogen N-hydroxy-2-acetylaminofluorene by cumene hydroperoxide-hematin.

1980 • 116 citations

Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. Formation of alkyl and alkoxyl radicals from tert-butyl hydroperoxide and cumene hydroperoxide.

1987 • 113 citations

Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide

1986 • 104 citations

ACTION OF HYDROGEN PEROXIDE ON HUMAN FIBROBLAST IN CULTURE

1979 • 99 citations

Hydrogen peroxide cytotoxicity. Low-temperature enhancement by ascorbate or reduced lipoate

1989 • 96 citations

Cell Killing and DNA Damage in Chinese Hamster V79 Cells Treated with Hydrogen Peroxide

1989 • 91 citations

Studies on the photolytic breakdown of hydroperoxides and peroxidized fatty acids by using electron spin resonance spectroscopy. Spin trapping of alkoxyl and peroxyl radicals in organic solvents

1986 • 87 citations

Effects of variation in glutathione peroxidase activity on DNA damage and cell survival in human cells exposed to hydrogen peroxide and t-butyl hydroperoxide

1990 • 86 citations

Three Classes of DNA Strand Breaks Induced by X-irradiation and Internal β-rays

1986 • 83 citations

Dissociation of the accumulation of single-strand breaks in DNA from the killing of cultured hepatocytes by an oxidative stress.

1989 • 76 citations

Detection of Induced DNA Strand Breaks with Improved Sensitivity in Human Cells

1980 • 75 citations

Deoxyribonucleic acid-protein and deoxyribonucleic acid interstrand crosslinks induced in isolated chromatin by hydrogen peroxide and ferrous ethylenediaminetetraacetate chelates

1982 • 60 citations

DNA repair kinetics after low doses of X-rays

1984 • 59 citations

DNA strand breaks induced by hydrogen peroxide in isolated rat hepatocytes

1988 • 45 citations

Induction and repair of DNA single-strand breaks in EM9 mutant cho cells treated with hydrogen peroxide

1987 • 43 citations

Variations among cultured cells in glutathione peroxidase activity in response to selenite supplementation

1987 • 33 citations

Differential effects of glutathione depletion and metallothionein induction on the induction of DNA single-strand breaks and cytotoxicity by tert-butyl hydroperoxide in cultured mammalian cells

1989 • 22 citations

Effects of iron chelators and glutathione depletion on the induction and repair of chromosomal aberrations by tert-butyl hydroperoxide in cultured Chinese hamster cells

1989 • 20 citations

Selenite-induced Increase in Glutathione Peroxidase Activity Protects Human Cells from Hydrogen Peroxide-induced DNA Damage, but Not from Damage Inflicted by Ionizing Radiation

1989 • 20 citations

Cellular Protection Against Damage by Hydroperoxides: Role of Glutathione

1988 • 14 citations

Electron Spin Resonance Studies on the Degradation of Hydroperoxides by Rat Liver Cytosol

1990 • 9 citations

A direct assay for detection of chemically induced changes in the rejoining kinetics of radiations induced DNA strand breaks

1987 • 8 citations

Lipid peroxidation increase Ca2+ permeability of hepatocyte plasma membrane

1990 • 4 citations

Structure of DNA-protein crosslinks formed in mammalian chromatin upon treatment with hydrogen peroxide and metal ions

1990 • 3 citations

“The derivative assay”—An analysis of two fast components of DNA rejoining kinetics

1989 • 2 citations