Coexpression of P2X(3) and P2X(2) receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons.

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

2000 • 1,016 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

1998 • 540 citations

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1997 • 492 citations

The Expression of P2X3Purinoreceptors in Sensory Neurons: Effects of Axotomy and Glial-Derived Neurotrophic Factor

1998 • 456 citations

Distinct ATP receptors on pain-sensing and stretch-sensing neurons

1997 • 452 citations

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals

1997 • 418 citations

Hetero-oligomeric Assembly of P2X Receptor Subunits

1999 • 411 citations

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds

1999 • 355 citations

Pharmacological characterization of recombinant human and rat P2X receptor subtypes

1999 • 328 citations

ATP P_2XReceptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal Cord

1997 • 264 citations

ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics

1990 • 243 citations

Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia

1998 • 224 citations

Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones.

1995 • 200 citations

Cell type‐specific ATP‐activated responses in rat dorsal root ganglion neurons

1999 • 181 citations

Acute nociception mediated by hindpaw P2X receptor activation in the rat

1997 • 180 citations

P2X Receptor–Mediated Ionic Currents in Dorsal Root Ganglion Neurons

1999 • 160 citations

Coexpression of Rat P2X₂and P2X₆Subunits inXenopusOocytes

2000 • 154 citations

ATP as a peripheral mediator of pain

2000 • 145 citations

Effects of extracellular pH on agonism and antagonism at a recombinant P2X₂ receptor

1997 • 144 citations

P2X receptor‐mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint

1998 • 143 citations

Characterization of cultured dorsal root ganglion neuron P2X receptors

1999 • 138 citations

ATP modulation of synaptic transmission in the spinal substantia gelatinosa

1995 • 119 citations

ATP P_2× Receptors and Sensory Synaptic Transmission Between Primary Afferent Fibers and Spinal Dorsal Horn Neurons in Rats

1998 • 115 citations

Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice

1999 • 110 citations

The antagonist trinitrophenyl‐ATP reveals co‐existence of distinct P2X receptor channels in rat nodose neurones

1998 • 101 citations

Diinosine pentaphosphate (IP₅I) is a potent antagonist at recombinant rat P2X₁ receptors

1999 • 97 citations

Pharmacological properties of P2X₃‐receptors present in neurones of the rat dorsal root ganglia

1998 • 91 citations

Zn²⁺ modulation of ATP‐responses at recombinant P2X₂ receptors and its dependence on extracellular pH

1998 • 89 citations

Properties of the novel ATP-gated ionotropic receptor composed of the P2X(1) and P2X(5) isoforms.

1999 • 82 citations

Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X₃ and P2X_2/3 receptors and between two P2X receptors in rat sensory neurones

2000 • 66 citations

Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons

1996 • 65 citations

Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues

1998 • 65 citations

Molecular Assembly of the Extracellular Domain of P2X2, an ATP-Gated Ion Channel

1997 • 61 citations

Characterization of P2 receptors modulating neural activity in rat rostral ventrolateral medulla

1999 • 53 citations

Activation of P2x-purinoceptors in the nucleus tractus solitarius elicits differential inhibition of lumbar and renal sympathetic nerve activity

1997 • 45 citations

Characterization of Ca²⁺ influx through recombinant P2X receptor in C6BU‐1 cells

1998 • 17 citations

Molecular Biology of P2X Purinoceptors

1998 • 15 citations

Zn2+ modulation of ATP-responses at recombinant P2X receptors: dependence on extracellular pH

1997 • 11 citations

Depression of C fiber-evoked activity by intrathecally administered reactive red 2 in rat thalamic neurons

1998 • 8 citations