The Roles of Bcl-XL and Apopain in the Control of Erythropoiesis by Erythropoietin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Reactive oxygen species and programmed cell death

1996 • 745 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor

1990 • 468 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2

1996 • 348 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties

1978 • 269 citations

ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

1996 • 267 citations

THE ROLE OF ERYTHROPOIETIN IN REGULATION OF POPULATION SIZE AND CELL CYCLING OF EARLY AND LATE ERYTHROID PRECURSORS IN MOUSE BONE MARROW

1977 • 251 citations

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.

1994 • 249 citations

Erythropoietin receptor characteristics on primary human erythroid cells

1991 • 249 citations

Purification of human blood burst‐forming units‐erythroid and demonstration of the evolution of erythropoietin receptors

1990 • 241 citations

Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin.

1987 • 225 citations

Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells

1988 • 198 citations

Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents

1996 • 171 citations

Apoptosis of human erythroid colony‐forming cells is decreased by stem cell factor and insulin‐like growth factor I as well as erythropoietin

1993 • 162 citations

Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: a mechanism for controlled rates of erythrocyte production

1993 • 153 citations

Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells [see comments]

1992 • 148 citations

Splenic erythroblasts in anemia‐inducing friend disease: A source of cells for studies of erythropoietin‐mediated differentiation

1984 • 146 citations

Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

1996 • 138 citations

Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.

1994 • 133 citations

Erythropoietic precursors in mice under erythropoietic stimulation and suppression.

1977 • 132 citations

Erythropoietin Induces the Tyrosine Phosphorylation, Nuclear Translocation, and DNA Binding of STAT1 and STAT5 in Erythroid Cells

1995 • 122 citations

Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells [see comments]

1992 • 110 citations

Primitive human hematopoietic precursors express Bcl-x but not Bcl-2

1995 • 104 citations

Evolutionary conservation of a genetic pathway of programmed cell death

1996 • 93 citations

Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)

1996 • 87 citations

Roles of erythropoietin, insulin-like growth factor 1, and unidentified serum factors in promoting maturation of purified murine erythroid colony-forming units

1992 • 78 citations

Erythropoietin receptors on murine erythroid colony-forming units: natural history

1989 • 78 citations

Control of red cell production: the roles of programmed cell death (apoptosis) and erythropoietin

1990 • 78 citations

Control of globin gene transcription by erythropoietin in erythroblasts from friend virus-infected mice.

1985 • 77 citations

Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.

1994 • 73 citations

BCL-2, a novel regulator of apoptosis

1996 • 63 citations

Abundance and stability of erythropoietin receptor mRNA in mouse erythroid progenitor cells

1991 • 42 citations

Erythropoietin Stimulates Transcription of the TAL1/SCL Gene and Phosphorylation of Its Protein Products

1995 • 39 citations

c-myc expression affects proliferation but not terminal differentiation or survival of explanted erythroid progenitor cells

1996 • 25 citations