Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

1993 • 949 citations

Cooperation between oncogenes

1991 • 792 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?

1979 • 513 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells

1994 • 418 citations

Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

1995 • 308 citations

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

1993 • 288 citations

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

1990 • 247 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Autologous marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle.

1990 • 174 citations

The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis (review).

1990 • 169 citations

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

1990 • 151 citations

Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial

1993 • 146 citations

Specific inhibition of c-myc protein biosynthesis using an antisense synthetic deoxy-oligonucleotide in human T lymphocytes.

1988 • 119 citations

Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy

1993 • 111 citations

Antisense inhibition of oncogene expression.

1992 • 109 citations

Stable expression of selectable genes introduced into human hematopoietic stem cells by electric field-mediated DNA transfer.

1986 • 108 citations

Analysis of Oligonucleotide Binding, Internalization, and Intracellular Trafficking Utilizing a Novel Radiolabeled Crosslinker

1992 • 95 citations

Electrochemotherapy—a novel method of cancer treatment

1994 • 94 citations

Cellular pharmacology of phosphorothioate homooligodeoxynucleotides in human cells.

1993 • 90 citations

One hundred twenty-five adult patients with primary acute leukemia autografted with marrow purged by mafosfamide: a 10-year single institution experience

1994 • 82 citations

Autologous Bone Marrow Transplantation in Relapsed Adult Acute Leukemia

1980 • 65 citations

Contribution of sequence and phosphorothioate content to inhibition of cell growth and adhesion caused by c-myc antisense oligomers.

1995 • 54 citations

Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission.

1993 • 52 citations

Inhibition of Protein-Tyrosine Kinase Activity in Intact Cells by the Aptameric Action of Oligodeoxynucleotides

1995 • 40 citations

Gene transfer by electroporation: a model for gene therapy.

1990 • 38 citations

ANTISENSE OLIGONUCLEOTIDES: A NEW TOOL IN NEUROSCIENCE

1994 • 37 citations

Elimination of clonogenic Philadelphia-positive cells using BCR-ABL antisense oligodeoxynucleotides.

1993 • 37 citations

Oligonucleotide Pharmacotherapy: An Antigene Strategy

1993 • 36 citations

Intensive combination chemotherapy and autologous bone marrow transplantation leads to the reappearance of philadelphia chromosome-negative cells in chronic myelogenous leukemia

1991 • 34 citations

In vivo expression of a nonselected gene transferred into murine hematopoietic stem cells by electroporation

1986 • 25 citations

Autotransplantation in Multiple Myeloma

1993 • 18 citations

In vivo effects of GM-CSF and IL-3 on hematopoietic cell recovery in bone marrow and blood after autologous transplantation with mafosfamide-purged marrow in lymphoid malignancies.

1994 • 17 citations

Oligodeoxynucleotide‐based therapeutics for human leukemias

1993 • 17 citations

Purging With 4-Hydroperoxycyclophosphamide

1992 • 17 citations

Applications of antisense oligonucleotides in oncology.

1994 • 17 citations

Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937

1993 • 16 citations

Immunomodulation by cytokine antisense oligonucleotides.

1995 • 15 citations

Enrichment for primitive hemopoietic progenitors of marrow cells from 5-fluorouracil-treated mice and normal mice.

1994 • 11 citations

Use of gel‐well culture chambers as a liquid culture system to measure responses of hematopoietic colony‐forming cells to growth factors

1989 • 9 citations

How do antisense oligodeoxynucleotides inhibit the growth of chronic myelogenous leukemia cells? [letter; comment]

1996 • 6 citations

The Use of Monoclonal Antibodies and Immune Markers in the Diagnosis, Prognosis, and Therapy of Acute Leukemia

1994 • 6 citations

Transplantation in multiple myeloma.

1995 • 6 citations

Heterotransplantation of Human Burkitt’s Lymphoma Cell Lines in Athymic Nude Mice: Tumor-Host Relationships

1993 • 3 citations

Antisense inhibition of CHP100 C-myc expression results in reduced in vitro growth kinetics and loss of in vivo tumorigenesis.

1994 • 3 citations