Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

AUTOANTIBODIES AGAINST NEUTROPHILS AND MONOCYTES: TOOL FOR DIAGNOSIS AND MARKER OF DISEASE ACTIVITY IN WEGENER'S GRANULOMATOSIS

1985 • 1,914 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase in Patients with Systemic Vasculitis and Idiopathic Necrotizing and Crescentic Glomerulonephritis

1988 • 1,431 citations

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

1990 • 1,214 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Anticytoplasmic Autoantibodies: Their Immunodiagnostic Value in Wegener Granulomatosis

1989 • 733 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Antineutrophil cytoplasmic antibodies

1998 • 451 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with wegener's granulomatosis

1993 • 293 citations

Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.

1994 • 293 citations

Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo

1994 • 285 citations

Ectosomes Released by Human Neutrophils Are Specialized Functional Units

1999 • 251 citations

Neutrophil priming: the cellular signals that say ‘amber’ but not ‘green’

1995 • 240 citations

Antibodies Against Granule Proteins Activate Neutrophils In Vitro

1991 • 226 citations

A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis

1999 • 223 citations

Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a FcγRII-dependent process

1994 • 219 citations

Anti-phospholipid autoantibodies bind to apoptotic, but not viable, thymocytes in a beta 2-glycoprotein I-dependent manner.

1996 • 210 citations

Elevated Circulating E-Selectin, Intercellular Adhesion Molecule 1, and von Willebrand Factor in Patients with Severe Infection

1998 • 205 citations

Association of autoantibodies to myeloperoxidase with different forms of vasculitis

1990 • 199 citations

Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils.

1997 • 192 citations

Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies

1995 • 163 citations

Presence of Proteinase 3 in Secretory Vesicles: Evidence of a Novel, Highly Mobilizable Intracellular Pool Distinct From Azurophil Granules

1999 • 163 citations

Antineutrophil Cytoplasmic Autoantibodies Interact with Primary Granule Constituents on the Surface of Apoptotic Neutrophils in the Absence of Neutrophil Priming

1996 • 147 citations

Mild Endotoxaemia and the Inflammatory Response Induced by a Marathon Race

1997 • 130 citations

Priming of Human Neutrophil Respiratory Burst by Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Involves Partial Phosphorylation of p47

1999 • 118 citations

Serum myeloperoxidase and serum cytokines in anti-myeloperoxidase antibody-associated glomerulonephritis.

1993 • 84 citations

Antineutrophil cytoplasmic antibodies preferentially engage Fc gammaRIIIb on human neutrophils.

1998 • 82 citations

Endotoxaemia, production of tumour necrosis factor ? and polymorphonuclear neutrophil activation following strenuous exercise in humans

1998 • 76 citations

Association of myeloperoxidase with heparin: oxidative inactivation of proteins on the surface of endothelial cells by the bound enzyme.

1998 • 71 citations

Modulation of human neutrophil inflammatory responses by nitric oxide: studies in unprimed and LPS-primed cells

1997 • 71 citations

Antineutrophil Cytoplasmic Antibodies Preferentially Engage FcγRIIIb on Human Neutrophils

1998 • 69 citations

Cross-linking of Fc gamma receptor IIa and Fc gamma receptor IIIb induces different proadhesive phenotypes on human neutrophils.

1997 • 65 citations

Comparison of Properties of Membrane Bound Versus Soluble Forms of Human Leukocytic Elastase and Cathepsin G

1994 • 63 citations

Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils

1999 • 51 citations

New developments in pathogenesis of systemic vasculitis

1998 • 50 citations

Priming of human neutrophil superoxide generation by tumour necrosis factor‐α is signalled by enhanced phosphatidylinositol 3,4,5‐trisphosphate but not inositol 1,4,5‐trisphosphate accumulation

1998 • 43 citations

Human mast cells expressing recombinant proteinase 3 (PR3) as substrate for clinical testing for anti-neutrophil cytoplasmic antibodies (ANCA)

1997 • 42 citations

Limited Prognostic Value of Changes in Antineutrophil Cytoplasmic Antibody Titers in Patients with Wegener’s Granulomatosis

1993 • 34 citations

Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis

1990 • 13 citations

Possible in vivo tolerance of human polymorphonuclear neutrophil to low-grade exercise-induced endotoxaemia

1998 • 12 citations

O-Phenylenediamine oxidation by phorbol myristate acetate-stimulated human polymorphonuclear leukocytes: Characterization of two distinct oxidative mechanisms

1987 • 11 citations

Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and other diseases: clinical issues

1994 • 8 citations

Sensibilité et spécificité des anticorps anticytoplasme des neutrophiles (c-ANCA) au cours des vascularites systémiques

1994 • 4 citations

The spectrum of disease associated with a positive ANCA

1993 • 4 citations