Kinetic Regulation of Catalytic and Transport Activities in Sarcoplasmic Reticulum ATPase

Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

1979 • 1,648 citations

Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.

1977 • 835 citations

Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

1979 • 718 citations

ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE

1962 • 701 citations

Sarcoplasmic Reticulum

1964 • 654 citations

Molecular mechanism of active calcium transport by sarcoplasmic reticulum.

1978 • 586 citations

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.

1978 • 520 citations

Relaxing factor and the relaxation of muscle

1964 • 477 citations

Isolation of sarcoplasmic reticulum by zonal centrifugation and purification of Ca2+-pump and Ca2+-binding proteins

1973 • 474 citations

Calcium Binding Activity of Vesicular Relaxing Factor

1961 • 441 citations

Cooperative calcium binding and ATPase activation in sarcoplasmic reticulum vesicles.

1980 • 384 citations

Aequorin Luminescence: Relation of Light Emission to Calcium Concentration—A Calcium-Independent Component

1977 • 364 citations

Reaction Mechanism of the Ca++-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle*

1967 • 331 citations

The Phosphorylation of the Membranal Protein of the Sarcoplasmic Vesicles during Active Calcium Transport

2005 • 263 citations

ATP synthesis by the reverse of the sarcoplasmic calcium pump

1971 • 261 citations

Acetyl Phosphate as Substrate for Ca2+ Uptake in Skeletal Muscle Microsomes

1971 • 252 citations

The Apparent Binding Constant of Glycoletherdiaminetetraacetic Acid for Calcium at Neutral pH*

1968 • 250 citations

A Borohydride Reduction Method for Characterization of the Acyl Phosphate Linkage in Proteins and Its Application to Sarcoplasmic Reticulum Adenosine Triphosphatase

1973 • 246 citations

Phosphorylation of the sarcoplasmic reticulum membrane by orthophosphate. Inhibition by calcium ions

1973 • 243 citations

Role of water, hydrogen ion, and temperature on the synthesis of adenosine triphosphate by the sarcoplasmic reticulum adenosine triphosphatase in the absence of a calcium ion gradient

1980 • 238 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle: V. Vectorial Requirements for Calcium and Magnesium Ions of Three Partial Reactions of ATPase: Formation and Decomposition of a Phosphorylated Intermediate and ATP-Formation from ADP and the Intermediate*

1971 • 237 citations

ATP and Ca2+ binding by the Ca2+ pump protein of sarcoplasmic reticulum

1973 • 225 citations

The reversibility of the sarcoplasmic calcium pump

1978 • 222 citations

ATP and active transport

1962 • 216 citations

The Effect of Calcium Ionophores on Fragmented Sarcoplasmic Reticulum

1972 • 215 citations

Occurrence and Characteristics of a Rapid Exchange of Phosphate Oxygens Catalyzed by Sarcoplasmic Reticulum Vesicles

1973 • 206 citations

Similarity of the Active Site of Phosphorylation of the Adenosine Triphosphatase for Transport of Sodium and Potassium Ions in Kidney to That for Transport of Calcium Ions in the Sarcoplasmic Reticulum of Muscle

1973 • 206 citations

New Complexon for Titration of Calcium in Presence of Magnesium

1957 • 199 citations

Sarcoplasmic reticulum. VII. Properties of a phosphoprotein intermediate implicated in calcium transport.

1969 • 198 citations

Structure and Function of the Calcium Pump Protein of Sarcoplasmic Reticulum

1982 • 196 citations

Effect of Diethyl Ether on the Adenosine Triphosphatase Activity and the Calcium Uptake of Fragmented Sarcoplasmic Reticulum of Rabbit Skeletal Muscle

1967 • 192 citations

Occlusion of Divalent Cations in the Phosphorylated Calcium Pump of Sarcoplasmic Reticulum

1980 • 191 citations

Indications for an oligomeric structure and for conformational changes in sarcoplasmic reticulum Ca2+-ATPase labelled selectively with fluorescein

1980 • 190 citations

Interaction of calcium and magnesium in activating and inhibiting the nucleoside triphosphatase of sarcoplasmic reticulum vesicles

1975 • 189 citations

Sarcoplasmic Reticulum

1969 • 188 citations

Cell and Muscle Motility

1982 • 185 citations

The interaction of vanadate ions with the Ca-ATPase from sarcoplasmic reticulum.

1982 • 178 citations

Adenosine 5'-triphosphate dependent fluxes of manganese and hydrogen ions in sarcoplasmic reticulum vesicles

1980 • 167 citations

The Utilization of Binding Energy in Coupled Vectorial Processes

1980 • 166 citations

Activation of calcium efflux by ADP and inorganic phosphate

1971 • 166 citations

Transport and inhibitory Ca2+ binding sites on the ATPase enzyme isolated from the sarcoplasmic reticulum.

1975 • 156 citations

Transient kinetics of Ca2+ transport of sarcoplasmic reticulum. A comparison of cardiac and skeletal muscle.

1978 • 155 citations

Calcium binding to the sarcoplasmic reticulum of rabbit skeletal muscle

1971 • 154 citations

A study of the phosphorylated intermediate of sarcoplasmic reticulum atpase

1970 • 154 citations

Formation of adenosine triphosphate from Pi and adenosine diphosphate by purified Ca-2+-adenosine triphosphatase.

1975 • 150 citations

Kinetics and Regulation of Sarcoplasmic Reticulum ATPase

1977 • 150 citations

Transient kinetics of sarcoplasmic reticulum Ca2++Mg2+ ATPase studied by fluorescence

1978 • 144 citations

Partial reactions in the catalytic and transport cycle of sarcoplasmic reticulum ATPase

1978 • 140 citations

Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum

1971 • 137 citations

Transient state kinetic effects of calcium ion on sarcoplasmic reticulum adenosine triphosphatase.

1976 • 137 citations

The use of quench reagents for resolution of single transport cycles in sarcoplasmic reticulum.

1979 • 136 citations

Role of the Ca²⁺ion concentration gradient in the adenosine 5'-triphosphate-inorganic phosphate exchange catalyzed by sarcoplasmic reticulum

1974 • 136 citations

Low-temperature studies of the sarcoplasmic reticulum calcium pump

1982 • 128 citations

Calcium efflux dependent formation of ATP from ADP and orthophosphate by the membranes of the sarcoplasmic vesicles

1971 • 125 citations

Modulation of calcium binding in sarcoplasmic reticulum adenosinetriphosphatase

1981 • 125 citations

Substrate Regulation of Membrane Phosphorylation and of Ca2+ Transport in the Sarcoplasmic Reticulum

1973 • 124 citations

Functional reassembly of membrane proteins in planar lipid bilayers

1981 • 123 citations

On a possible mechanism of energy conservation in sarcoplasmic reticulum membrane.

1976 • 121 citations

Reaction Mechanism of the Ca++-Dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle*

1968 • 116 citations

The Calcium Binding Sites Involved in the Regulation of the Purified Adenosine Triphosphatase of the Sarcoplasmic Reticulum

1974 • 115 citations

Phosphoprotein formation during osmo‐chemical energy conversion in the membrane of the sarcoplasmic reticulum

1972 • 114 citations

Fast kinetics of adenosine triphosphate dependent Ca²⁺ uptake by fragmented sarcoplasmic reticulum

1972 • 112 citations

Reaction mechanism of Ca2+-dependent ATP hydrolysis by skeletal muscle sarcoplasmic reticulum in the absence of added alkali metal salts. II. Kinetic properties of the phosphoenzyme formed at the steady state in high Mg2+ and low Ca2+ concentrations.

1978 • 111 citations

A new mechanism by which an H⁺concentration gradient drives the synthesis of adenosine triphosphate, pH jump, and adenosine triphosphate synthesis by the Ca²⁺ dependent adenosine triphosphatase of sarcoplasmic reticulum

1977 • 110 citations

Substrate regulation of the sarcoplasmic reticulum ATPase. Transient kinetic studies.

1979 • 110 citations

A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models.

1980 • 109 citations

Phosphorylation of solubilized sarcoplasmic reticulum by orthophosphate and its thermodynamic characteristics. The dominant role of entropy in the phosphorylation.

1975 • 108 citations

Conformational heterogeneity of the copper binding site in azurin. A time-resolved fluorescence study

1983 • 106 citations

Ca2+-dependent effect of ATP on spin-labeled sarcoplasmic reticulum.

1977 • 104 citations

Fast-kinetic evidence for an activating effect of ATP on the Ca2+ transport of sarcoplasmic reticulum ATPase.

1979 • 101 citations

Reaction mechanism of Ca2+-dependent ATP hydrolysis by skeletal muscle sarcoplasmic reticulum in the absence of added alkali metal salts. III. Sequential occurrence of ADP-sensitive and ADP-insensitive phosphoenzymes.

1978 • 101 citations

Pseudosubstrates of the sarcoplasmic Ca2+-ATPase as tools to study the coupling between substrate hydrolysis and Ca2+ transport

1979 • 98 citations

Kinetics of the cooperativity of the Ca2+-transporting adenosine triphosphatase of sarcoplasmic reticulum and the mechanism of the ATP interaction

1977 • 98 citations

Metal Chelate Stability Constants of Aminopolycarboxylate Ligands

1960 • 97 citations

The use of 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate for studies of nucleotide interaction with sarcoplasmic reticulum vesicles.

1982 • 93 citations

Calcium Gradient‐Dependent and Calcium Gradient‐Independent Phosphorylation of Sarcoplasmic Reticulum by Orthophosphate

1978 • 92 citations

Sarcoplasmic Reticulum

1971 • 92 citations

Calcium and proton dependence of sarcoplasmic reticulum ATPase

1983 • 89 citations

Can free energy transduction be localized at some crucial part of the enzymatic cycle?

1981 • 88 citations

Phosphorylation of the sarcoplasmic reticulum membrane by orthophosphate through two different reactions

1974 • 87 citations

Binding of cations by microsomes from rabbit skeletal muscle

1966 • 86 citations

Characterization of Cardiac Sarcoplasmic Reticulum ATP‐ADP Phosphate Exchange and Phosphorylation of the Calcium Transport Adenosine Triphosphatase

1976 • 83 citations

ATP synthesis by sarcoplasmic reticulum ATPase following Ca2+, PH, temperature, and water activity jumps.

1982 • 82 citations

Dynamic reversal of enzyme carboxyl group phosphorylation as the basis of the oxygen exchange catalyzed by sarcoplasmic reticulum adenosine triphosphatase

1977 • 82 citations

Effects of divalent cations and nucleotides on the reactivity of the sulfhydryl groups of sarcoplasmic reticulum membranes. Evidence for structural changes occurring during the calcium transport cycle.

1978 • 80 citations

ELEMENTARY PROCESSES IN THE HYDROLYSIS OF ATP BY SARCOPLASMIC RETICULUM MEMBRANES*

1974 • 80 citations

Calcium Binding to Sarcoplasmic Membranes

1971 • 80 citations

Behavior of the Ca2+ transport sites linked with the phosphorylation reaction of ATPase purified from the sarcoplasmic reticulum.

1976 • 77 citations

Ca2+ Uptake and Acetyl Phosphatase of Skeletal Muscle Microsomes

1969 • 77 citations

Slow dissociation of ATP from the calcium ATPase.

1982 • 75 citations

Regulation of steady state level of phosphoenzyme and ATP synthesis in sarcoplasmic reticulum vesicles during reversal of the Ca2+ pump.

1976 • 72 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1972 • 71 citations

Sarcoplasmic reticulum ATPase phosphorylation from inorganic phosphate in the absence of a calcium gradient. Steady state and kinetic fluorescence studies.

1981 • 68 citations

High and low affinity Ca2+ binding to the sarcoplasmic reticulum: use of a high-affinity fluorescent calcium indicator

1977 • 68 citations

Ca2+-controlled conformational states of the Ca2+ transport enzyme of sarcoplasmic reticulum.

1978 • 67 citations

Biphasic kinetics of ATP hydrolysis by calcium-dependent ATPase of the sarcoplasmic reticulum of skeletal muscle. Evidence for a nucleoside triphosphate effector site.

1979 • 67 citations

Phosphorylation from Inorganic Phosphate and ATP Synthesis of Sarcoplasmic Membranes

1977 • 66 citations

Slow transition of phosphoenzyme from ADP-sensitive to ADP-insensitive forms in solubilized Ca2+, Mg2+-ATPase of sarcoplasmic reticulum: Evidence for retarded dissociation of Ca2+ from the phosphoenzyme

1979 • 66 citations

Properties of the Sarcoplasmic ATPase Reconstituted by Oleate and Lysolecithin after Lipid Depletion

1972 • 65 citations

Proton gradient formation during transport of Ca2+ by sarcoplasmic reticulum

1978 • 65 citations

Vanadate inhibition of the Ca²⁺‐dependent conformational change of the sarcoplasmic reticulum Ca²⁺‐ATPase

1982 • 65 citations

Interdependence of H+, Ca2+, and Pi (or vanadate) sites in sarcoplasmic reticulum ATPase.

1984 • 64 citations

Detection of an initial burst of Ca2+ translocation in sarcoplasmic reticulum

1977 • 63 citations

The Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle

1961 • 62 citations

Equilibrium cooperative binding of calcium and protons by sarcoplasmic reticulum ATPase.

1982 • 58 citations

Allosteric Inhibition by Alkali Ions of the Ca2+ Uptake and Adenosine Triphosphatase Activity of Skeletal Muscle Microsomes

1971 • 56 citations

Phosphorylation of skeletal muscle microsomes by acetylphosphate

1970 • 54 citations

Sequential reactions in Pi utilization for ATP synthesis by sarcoplasmic reticulum.

1979 • 52 citations

Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum

1971 • 52 citations

pH-Induced changes in the reactions controlled by the low- and high-affinity calcium(2+)-binding sites in sarcoplasmic reticulum

1977 • 52 citations

Calcium and magnesium regulation of phosphorylation by ATP and ITP in sarcoplasmic reticulum vesicles.

1976 • 52 citations

Rapid kinetic studies of active Ca2+ transport in sarcoplasmic reticulum

1980 • 50 citations

The binding of nucleotides and bivalent cations to the calcium-and-magnesium ion-dependent adenosine triphosphatase from rabbit muscle sarcoplasmic reticulum

1976 • 49 citations

Phosphorylation of (Ca2+)-adenosinetriphosphatase by inorganic phosphate: van't Hoff analysis of enthalpy changes

1981 • 49 citations

Mechanism of calcium‐independent phosphorylation of sarcoplasmic reticulum ATPase by orthophosphate

1979 • 48 citations

Structural effects of substrate utilization on the ATPase chains of sarcoplasmic reticulum

1982 • 46 citations

Uncoupling of calcium control and phosphohydrolase activity in sarcoplasmic reticulum vesicles.

1980 • 46 citations

Ionized and Bound Calcium Inside Isolated Sarcoplasmic Reticulum of Skeletal Muscle and Its Significance in Phosphorylation of Adenosine Triphosphatase by Orthophosphate

1979 • 43 citations

Induction by nucleotide triphosphate hydrolysis of a form of sarcoplasmic reticulum ATPase capable of medium phosphate-oxygen exchange in presence of calcium.

1978 • 42 citations

[The influence of oxalate on calcium transport of isolated sarcoplasmic reticular vesicles].

1965 • 42 citations

Effect of calcium and magnesium on binding of beta, gamma-methylene ATP to sarcoplasmic reticulum.

1977 • 41 citations

Phosphorylation by Inorganic Phosphate of Sarcoplasmic Membranes

1977 • 41 citations

The Binding of Calcium and Magnesium to Sarcoplasmic Reticulum Vesicles as Studied by Manganese Electron Paramagnetic Resonance

1978 • 40 citations

Effects of anions, pH and magnesium on calcium accumulation and release by sarcoplasmic reticulum vesicles

1977 • 40 citations

Comparison between ATP-Supported and GTP-Supported Phosphate Turnover of the Calcium-Transporting Sarcoplasmic Reticulum Membranes

1979 • 38 citations

Interaction of fragmented sarcoplasmic reticulum with 14C-ADP, 14C-ATP, and 32P-ATP. Effect of Ca and Mg

1968 • 36 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1973 • 35 citations

The Structure and Function of Sarcoplasmic Reticulum Membranes

1971 • 35 citations

THE MECHANISM OF SARCOPLASMIC RETICULUM ATPase*

1982 • 34 citations

Effect of temperature on the Ca2+ transport ATPase of sarcoplasmic reticulum

1977 • 34 citations

ATP ↔P_i exchange and membrane phosphorylation in sarcoplasmic reticulum vesicles. Activation by silver in the absence of Ca²⁺ ion concentration gradient

1975 • 34 citations

Spin labelled sarcoplasmic reticulum vesicles: Ca²⁺‐induced spectral changes

1976 • 33 citations

Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis.

1982 • 32 citations

Reaction Mechanism of p-Nitrophenylphosphatase of Sarcoplasmic Reticulum

1978 • 31 citations

The Modification of the Reconstituted Sarcoplasmic ATPase by Monovalent Cations

1972 • 29 citations

The initial phase of Ca²⁺‐uptake and ATPase activity of sarcoplasmic reticulum vesicles

1977 • 27 citations

Binding and Release of Cations by Sarcoplasmic Reticulum before and after Removal of Lipid

1972 • 26 citations

Allosteric modification by K+ of the (Ca2+ + Mg2+)-dependent ATPase of sarcoplasmic reticulum. Interaction with Mg2+.

1978 • 26 citations

Phosphorylation of the Ca2+-Mg2+-dependent ATPase of the Sarcoplasmic Reticulum Coupled with Cation Translocation*

1972 • 22 citations

Pathway for ATP synthesis by sarcoplasmic reticulum ATPase

1980 • 22 citations

Mechanism of active transport: free energy dissipation and free energy transduction.

1982 • 21 citations

Steady state of an ATP-driven calcium pump: limitations on kinetic and thermodynamic parameters.

1982 • 21 citations

ATP-Pi and ITP-Pi exchange by cardiac sarcoplasmic reticulum

1979 • 17 citations

The Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle

1981 • 14 citations

Ca2+-dependent inhibitory effects of Na+ and K− on Ca2+ transport in sarcoplasmic reticulum vesicles

1975 • 13 citations

Transient-state kinetic studies on the mechanism of furylacryloylphosphatase-coupled calcium ion transport with sarcoplasmic reticulum adenosine triphosphatase

1981 • 9 citations

ATP synthesis by Ca2+ + Mg2+-ATPase in detergent solution at constant Ca2+ levels

1980 • 8 citations

Die Nucleosidtriphosphat-Nukleosiddiphosphat-Transphosphorylase-Aktivität der Vesikel des sarkoplasmatischen Retikulums

1966 • 7 citations

Gibt es zwei phosphorylierte Intermediate des aktiven Calcium-Transportes in den Membranen des Sakroplasmatischen Reticulums?

1967 • 5 citations