Synapsin I, A Phosphoprotein Associated with Synaptic Vesicles: Possible Role in Regulation of Neurotransmitter Release

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

The role of protein phosphorylation in neural and hormonal control of cellular activity

1982 • 1,116 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

1984 • 610 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.

1983 • 555 citations

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.

1983 • 535 citations

Protein Phosphorylation and Neuronal Function

1985 • 525 citations

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C

1985 • 476 citations

Casein Kinases—Multipotential Protein Kinases

1982 • 454 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

1977 • 411 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

Presynaptic calcium currents in squid giant synapse

1981 • 366 citations

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

1978 • 346 citations

A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions

1983 • 342 citations

Regulation of Endogenous Phosphorylation of Specific Proteins in Synaptic Membrane Fractions from Rat Brain by Adenosine 3′:5′-Monophosphate

1973 • 341 citations

Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

1978 • 332 citations

Protein phosphorylation in the nervous system

1984 • 329 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum.

1985 • 301 citations

Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites.

1981 • 296 citations

Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain.

1984 • 292 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Neural Tissues Express High Levels of the Cellular src Gene Product pp60^c-src

1983 • 288 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization

1983 • 265 citations

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.

1982 • 257 citations

Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.

1984 • 248 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1983 • 247 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain

1984 • 241 citations

Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

1981 • 233 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus

1984 • 209 citations

PHOSPHORYLATION OF LIVER HISTONE FOLLOWING THE ADMINISTRATION OF GLUCAGON AND INSULIN

1969 • 208 citations

Synapsin I in Nerve Terminals: Selective Association with Small Synaptic Vesicles

1984 • 205 citations

Dissociation and reassociation of the phosphorylated and nonphosphorylated forms of adenosine 3':5' -monophosphate-dependent protein kinase from bovine cardiac muscle.

1976 • 197 citations

ACTH, cyclic nucleotides, and brain protein phosphorylation in vitro

1976 • 181 citations

Receptor biochemistry and methodology

1985 • 181 citations

Neural tissues express high levels of the cellular src gene product pp60c-src.

1983 • 179 citations

Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices.

1978 • 178 citations

Protein phosphorylation in the nervous system.

1985 • 177 citations

Adenosine 3′,5-Monophosphatedependent Phosphorylation of a Specific Protein in Synaptic Membrane Fractions from Rat Cerebrum

1972 • 177 citations

Cyclic AMP-dependent phosphorylation of the alpha subunit of the sodium channel in synaptic nerve ending particles.

1984 • 169 citations

Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinase.

1982 • 168 citations

Synaptic Phosphoproteins: Specific Changes After Repetitive Stimulation of the Hippocampal Slice

1979 • 162 citations

Ca2+ -activated K+ conductance in internally perfused snail neurons is enhanced by protein phosphorylation.

1982 • 158 citations

Purification and properties of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase.

1980 • 157 citations

The Functioning of the Giant Nerve Fibres of the Squid1

1938 • 153 citations

Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation.

1984 • 151 citations

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

1980 • 149 citations

An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum

1978 • 140 citations

Tyrosine 3-monooxygenase is phosphorylated by Ca2+-, calmodulin-dependent protein kinase, followed by activation by activator protein

1981 • 138 citations

A multifunctional calmodulin‐dependent protein kinase

1983 • 134 citations

Receptor Biochemistry ahd Methodology

1984 • 122 citations

Calcium in Synaptic Transmission

1982 • 121 citations

Phosphorylation of acetylcholine receptor by endogenous membrane protein kinase in receptor-enriched membranes of Torpedo californica

1977 • 113 citations

Phosphorylation of the? subunit of the sodium channel by protein kinase C

1984 • 111 citations

Widespread distribution of protein I in the central and peripheral nervous systems.

1979 • 108 citations

A technique for recording functional activity in specific groups of medullated and non‐medullated fibres in whole nerve trunks

1957 • 95 citations

Intracellular injection of protein kinase inhibitor blocks the serotonin-induced increase in K+ conductance in Aplysia neuron R15.

1982 • 93 citations

Protein Kinase Injection Reduces Voltage-Dependent Potassium Currents

1983 • 90 citations

Self-phosphorylation of cyclic guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung. Effect of cyclic adenosine 3':5'-monophosphate, cyclic guanosine 3':5'-monophosphate and histone.

1977 • 90 citations

A specific substrate from rabbit cerebellum for guanosine-3‘:5‘-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites.

1981 • 88 citations

A specific substrate from rabbit cerebellum for guanosine 3‘:5‘-monophosphate-dependent protein kinase. I. Purification and characterization.

1981 • 85 citations

Nerve impulses increase the phosphorylation state of protein I in rabbit superior cervical ganglion

1982 • 85 citations

Dopamine and depolarizing agents regulate the state of phosphorylation of protein I in the mammalian superior cervical sympathetic ganglion.

1980 • 84 citations

Serotonin stimulates phosphorylation of Protein I in the facial motor nucleus of rat brain

1981 • 80 citations

Calsequestrin, Myosin, and the Components of the Protein‐Glycogen Complex in Rabbit Skeletal Muscle

1978 • 76 citations

Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.

1985 • 68 citations

Purification and characterization of protein IIIb, a mammalian brain phosphoprotein.

1982 • 64 citations

Evidence for phosphorylation of rat brain guanylate cyclase by cyclic AMP-dependent protein kinase

1981 • 61 citations

Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.

1981 • 61 citations

A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.

1981 • 60 citations

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents.

1982 • 58 citations

Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein.

1982 • 57 citations

Evidence for protein phosphorylation and dephosphorylation in membrane fragments isolated from the electric organ of Electrophorus electricus

1977 • 52 citations

Regulation of the Muscarinic Acetylcholine Receptor: Effects of Phosphorylating Conditions on Agonist and Antagonist Binding

1983 • 51 citations

Isolation of brain Ca2+-calmodulin tubulin kinase containing calmodulin binding proteins

1982 • 45 citations

Protein kinases of retinal rod outer segments: identification and partial characterization of cyclic nucleotide dependent protein kinase and rhodopsin kinase

1981 • 45 citations

Synapsin Ia, Synapsin Ib, Protein IIIa, and Protein IIIb, Four Related Synaptic Vesicle‐Associated Phosphoproteins, Share Regional and Cellular Localization in Rat Brain

1988 • 44 citations

Cross‐Reaction of Anti‐Rat B‐50: Characterization and Isolation of a “B‐50 Phosphoprotein” from Bovine Brain

1984 • 43 citations

Cellular and subcellular localization of protein I in the peripheral nervous system.

1982 • 41 citations

Neuronal localization of specific brain phosphoproteins

1978 • 36 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus

1981 • 36 citations

Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus.

1981 • 36 citations

Phosphorylation induces a decrease in the biological activity of the protein inhibitor (GABA-modulin) of gamma-aminobutyric acid binding sites.

1983 • 35 citations

The Squid Giant Synapse

1984 • 34 citations

ACTH and Synaptic Membrane Phosphorylation in Rat Brain

1982 • 33 citations

Evidence that High Frequency Stimulation Influences the Phosphorylation of Pyruvate Dehydrogenase and that the Activity of this Enzyme is Linked to Mitochondrial Calcium Sequestration

1982 • 33 citations

Role of calmodulin in the activation of tryptophan hydroxylase.

1982 • 29 citations

D-l and D-2 dopaminergic receptors regulate protein phosphorylation in the rat neurohypophysis

1985 • 27 citations

Attachment of the Synapse‐Specific Phosphoprotein Protein I to the Synaptic Membrane: A Possible Role of the Collagenase‐Sensitive Region of Protein I

1981 • 23 citations

Protein Phosphorylation in the Regulation and Adaptation of Receptor Function

1982 • 17 citations

Long-term potentiation in the hippocampal slice: Possible involvement of pyruvate dehydrogenase

1984 • 16 citations

Nuclear Protein Phosphorylation and the Regulation of Gene Expression

1982 • 12 citations

Activation of Multiple S6 Phosphorylation and its Possible Role in the Alteration of mRNA Expression

1982 • 9 citations

Possible nuclear protein kinase regulation of homologous ribonucleic acid polymerases from small dense nuclei of mouse brain during morphine tolerance-dependence

1981 • 9 citations

Ribosomal Protein Phosphorylation and Protein Synthesis in the Brain

1982 • 4 citations