Distinct activated and non-activated RNA polymerase II complexes in yeast.

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

1983 • 1,095 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae

1987 • 676 citations

The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

1988 • 662 citations

An RNA polymerase II holoenzyme responsive to activators

1994 • 586 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.

1980 • 410 citations

Eucaryotic RNA Polymerase Conditional Mutant that Rapidly Ceases mRNA Synthesis

1987 • 353 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

1991 • 319 citations

Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II

1987 • 306 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.

1992 • 266 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II.

1989 • 250 citations

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.

1995 • 245 citations

Transcriptional elongation by RNA polymerase II is stimulated by transactivators

1994 • 243 citations

Construction of an improved host strain for two hybrid screening

1994 • 242 citations

Transcription on nucleosomal templates by RNA polymerase II in vitro: inhibition of elongation with enhancement of sequence-specific pausing.

1991 • 239 citations

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

1995 • 239 citations

Association of an activator with an RNA polymerase II holoenzyme.

1995 • 237 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.

1995 • 220 citations

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1992 • 219 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Conserved Arrangement of Nested Genes at the Drosophila Gart Locus

1987 • 184 citations

Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.

1992 • 182 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Postinitiation Transcriptional Control in Drosophila melanogaster

1990 • 177 citations

A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1

1991 • 176 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID

1992 • 170 citations

RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals

1990 • 163 citations

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

1992 • 162 citations

RNA polymerase II C-terminal domain required for enhancer-driven transcription

1995 • 155 citations

DNA Melting on Yeast RNA Polymerase II Promoters

1993 • 154 citations

An RNA polymerase I enhancer in Saccharomyces cerevisiae.

1986 • 151 citations

Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes.

1987 • 132 citations

The TBP-TFIIA Interaction in the Response to Acidic Activators in Vivo

1995 • 132 citations

Mutations in RNA polymerase II enhance or suppress mutations in GAL4.

1989 • 123 citations

A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.

1995 • 123 citations

Increased Recruitment of TATA-Binding Protein to the Promoter by Transcriptional Activation Domains in Vivo

1994 • 114 citations

Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation.

1990 • 114 citations

Functional distinctions between yeast TATA elements.

1989 • 111 citations

Regulation of transcriptional elongation by RNA polymerase II

1995 • 111 citations

Effects of activation-defective TBP mutations on transcription initiation in yeast

1994 • 110 citations

Recruiting TATA-Binding Protein to a Promoter: Transcriptional Activation without an Upstream Activator

1995 • 108 citations

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

1986 • 96 citations

The multifunctional TFIIH complex and transcriptional control

1994 • 88 citations

TBP mutants defective in activated transcription in vivo.

1995 • 87 citations

The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat

1993 • 85 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

Sequence of the Saccharomyces GAL region and its transcription in vivo

1984 • 78 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

An RNA Polymerase I Enhancer in Saccharomyces cerevisiae

1986 • 62 citations

Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences.

1994 • 53 citations

A Three-Step Pathway of Transcription Initiation Leading to Promoter Clearance at an Activated RNA Polymerase II Promoter

1996 • 52 citations

Distinct modes of transcription read through or terminate at the c-myc attenuator.

1992 • 48 citations

Involvement of the SIN4 Global Transcriptional Regulator in the Chromatin Structure of Saccharomyces cerevisiae

1992 • 39 citations

Functional Distinctions between Yeast TATA Elements

1989 • 37 citations

mRNA transcription in nuclei isolated from Saccharomyces cerevisiae.

1986 • 29 citations

mRNA Transcription in Nuclei Isolated from Saccharomyces cerevisiae

1986 • 10 citations