Fibrin as a component of the tumor stroma: origins and biological significance

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Fibronectins—adhesive glycoproteins of cell surface and blood

1978 • 1,418 citations

Cellular Adhesiveness and Extracellular Substrata

1978 • 829 citations

The ɛ-(γ-Glutamyl)Lysine Crosslink and the Catalytic Role of Transglutaminases

1977 • 813 citations

Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features.

1977 • 674 citations

TROUSSEAUʼS SYNDROME AND OTHER MANIFESTATIONS OF CHRONIC DISSEMINATED COAGULOPATHY IN PATIENTS WITH NEOPLASMS

1977 • 547 citations

High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in maglinant transformation

1978 • 515 citations

Mitogenic activity of blood components. I. Thrombin and prothrombin.

1975 • 481 citations

Tumor Angiogenesis

1974 • 470 citations

Proceedings: Tumor angiogenesis factor.

1974 • 469 citations

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule

1981 • 444 citations

Molecular mechanism of physiological fibrinolysis

1978 • 410 citations

Interstitial fluid volume: local regulatory mechanisms.

1981 • 395 citations

Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.

1981 • 372 citations

The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin.

1980 • 342 citations

Tumor Shedding and Coagulation

1981 • 291 citations

Studies of the Procoagulant and Fibrinolytic Activity of Promyelocytes in Acute Promyelocytic Leukaemia

1973 • 236 citations

Induction of a Fibrin-Gel Investment: An Early Event in Line 10 Hepatocarcinoma Growth Mediated by Tumor-Secreted Products

1979 • 230 citations

An association between actin and the major histocompatibility antigen H–2

1978 • 226 citations

A factor X-activating cysteine protease from malignant tissue.

1981 • 221 citations

Shedding from the Cell Surface of Normal and Cancer Cells

1980 • 215 citations

Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation.

1981 • 212 citations

Cancer procoagulant A: A factor X activating procoagulant from malignant tissue

1975 • 211 citations

Macrophage production of fibronectin, a chemoattractant for fibroblasts.

1981 • 211 citations

The Role of Serine Proteases in the Blood Coagulation Cascade

1979 • 208 citations

ROLE OF THE CLOTTING SYSTEM IN CELL-MEDIATED HYPERSENSITIVITY

1973 • 208 citations

Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts

1977 • 205 citations

Coagulative properties of cancers

1958 • 201 citations

Fibrin Gel Investment Associated With Line 1 and Line 10 Solid Tumor Growth, Angiogenesis, and Fibroplasia in Guinea Pigs. Role of Cellular Immunity, Myofibroblasts, Microvascular Damage, and Infarction in Line 1 Tumor Regression<xref ref-type="fn" rid="FN2">2</xref>

1979 • 198 citations

Bulk transfer of fluid in the interstitial compartment of mammary tumors.

1975 • 198 citations

Purification and characterization of bovine tissue factor.

1981 • 196 citations

Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung

1981 • 191 citations

Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.

1980 • 186 citations

Association of tissue factor activity with the surface of cultured cells.

1975 • 182 citations

BASOPHILIC LEUKOCYTES IN ALLERGIC CONTACT DERMATITIS

1972 • 179 citations

Occult Cancer in Patients with Acute Pulmonary Embolism

1982 • 175 citations

The chemistry and physiology of human plasma proteins

1980 • 167 citations

Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes.

1977 • 166 citations

Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts

1977 • 161 citations

Mononuclear cell tissue factor: cell of origin and requirements for activation

1979 • 160 citations

TUMORS, MUCUS PRODUCTION, AND HYPERCOAGULABILITY

1974 • 147 citations

Role of the clotting system in cell-mediated hypersensitivity. II. Kinetics of fibrinogen/fibrin accumulation and vascular permeability changes in tuberculin and cutaneous basophil hypersensitivity reactions.

1975 • 147 citations

Differences in domain structures between plasma and cellular fibronectins.

1981 • 146 citations

Some Relationships among Hemostasis, Fibrinolytic Phenomena, Immunity, and the Inflammatory Response

1969 • 140 citations

Fibrin: Structure and Interactions

1982 • 138 citations

Chemotaxis for Human Monocytes by Fibrinogen‐derived Peptides

1976 • 138 citations

Rejection of first-set skin allografts in man. the microvasculature is the critical target of the immune response.

1979 • 134 citations

A difference between plasma and cellular fibronectins located with monoclonal antibodies

1981 • 132 citations

Plasmic Degradation of Crosslinked Fibrin

1980 • 128 citations

The activation of coagulation by extracts of mucus: a possible pathway of intravascular coagulation accompanying adenocarcinomas.

1973 • 127 citations

The role of human T cells (and T cell products) for monocyte tissue factor generation.

1980 • 125 citations

A study of the mechanism by which anticoagulation with warfarin inhibits blood-borne metastases.

1973 • 119 citations

A mechanism of migration inhibition in delayed-type hypersensitivity reactions. II. Lymphokines promote procoagulant activity of macrophages in vitro.

1981 • 118 citations

MALIGNANCY AND HAEMOSTASIS

1980 • 117 citations

Tissue Factor Activity in Lymphocyte Cultures from Normal Individuals and Patients with Hemophilia A

1973 • 112 citations

Anticoagulants in the treatment of cancer

1976 • 111 citations

Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

1978 • 106 citations

Human Breast Carcinoma: Fibrin Deposits ans Desmoplasia. Inflammatory Cell Type and Distribution. Microvasculature and Infarction<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 104 citations

Rationale and experimental design for the va cooperative study of anticoagulation (warfarin) in the treatment of cancer

1979 • 104 citations

Localization <italic>In Vivo</italic> of Radioiodinated Anti-Rat-Fibrin Antibodies and Radioiodinated Rat Fibrinogen in the Murphy Rat Lymphosarcoma and in Other Transplantable Rat Tumors<xref ref-type="fn" rid="FN1">2</xref>

1959 • 103 citations

Leukocyte procoagulant activity in man: an in vitro correlate of delayed-type hypersensitivity.

1982 • 100 citations

Demonstration of fibrin in early stages of experimental metastases.

1976 • 99 citations

Cell surface shedding—The phenomenon and its possible significance

1976 • 92 citations

Effect of fibrin degradation products on microvascular permeability

1978 • 92 citations

Role of the Clotting System in Cell-Mediated Hypersensitivity

1975 • 91 citations

Radioimmunoassay of Fibrinopeptides in Relation to Intravascular Coagulation and Thrombosis

1976 • 89 citations

Evidence that cells from experimental tumours can activate coagulation factor X

1979 • 87 citations

Delayed-Type Hypersensitivity Skin Reactions in Congenital Afibrinogenemia Lack Fibrin Deposition and Induration

1979 • 87 citations

Thromboplastic and fibrinolytic activities of cultured human cancer cell lines

1979 • 86 citations

Cytological observations on carcinoma

1958 • 85 citations

Malignancy and the Hemostatic System

1982 • 85 citations

131I-labeled antibodies to human fibrinogen.Diagnostic studies and therapeutic trials

1967 • 83 citations

Immune complex-induced human monocyte procoagulant activity. I. a rapid unidirectional lymphocyte-instructed pathway.

1981 • 81 citations

Thrombogenic activity of mouse and human tumors: effects on platelets, coagulation, and fibrinolysis, and possible significance for metastases

1976 • 77 citations

The kinetics and metabolic requirements for direct lymphocyte induction of human procoagulant monokines by bacterial lipopolysaccharide.

1981 • 76 citations

Aggregation of platelets and cell membrane vesiculation by rat cells transformed in vitro by Rous sarcoma virus.

1978 • 74 citations

Immunosuppression by micromolecular fibrinogen degradation products in cancer

1976 • 74 citations

Fibronectin.

1980 • 72 citations

Fibrin in human tumors.

1960 • 71 citations

Comparison of Procoagulant Activities in Extracts of Normal and Malignant Human Tissue&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 69 citations

IMMUNOLOGIC REJECTION OF DIETHYLNITROSAMINE-INDUCED HEPATOMAS IN STRAIN 2 GUINEA PIGS

1973 • 69 citations

Increased Production and Expression of Tissue Thromboplastin-Like Procoagulant Activity In Vitro by Allogeneically Stimulated Human Leukocytes

1978 • 68 citations

Isolation of vasoactive peptides from human fibrin and fibrinogen degraded by plasmin

1978 • 68 citations

The Chemotactic Activity of Fibrin Lysis Products

1972 • 68 citations

Disseminated intravascular coagulation in cancer patients: Supportive evidence

1973 • 67 citations

Lodgement and extravasation of tumour cells in blood-borne metastasis: an electron microscope study

1978 • 67 citations

A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS. A POSSIBLE MEDIATOR OF THE DELAYED REACTION.

1963 • 66 citations

Techniques for inhibiting tumor metastases

1975 • 64 citations

Hematologic changes and thromboembolic complications in neoplastic disease and their relationship to metastasis.

1975 • 61 citations

Studies on the physiological activity of the peptide released during the fibrinogen-fibrin conversion

1964 • 59 citations

Blood coagulation and the inflammatory response.

1977 • 58 citations

Variations in the staining characteristics of human fibrin.

1957 • 58 citations

Generation of chemotactic activity for leukocytes by the action of thrombin on human fibrinogen.

1973 • 57 citations

Comparison of procoagulant activity in tissue culture medium from normal and transformed fibroblasts.

1978 • 57 citations

Beitrag zur Biologie der Gewebezellen

1925 • 56 citations

Hemostatic abnormalities associated with malignant diseases

1977 • 55 citations

Structure-activity relationships of vasoactive peptides derived from fibrin or fibrinogen degraded by plasmin

1980 • 54 citations

Antibody-Induced Modulation and Shedding of Mammary Tumor Virus Antigens on the Surfaces of GR Ascites Leukemia Cells as Compared With Normal Antigens2

1976 • 51 citations

Tissue factor activity of normal and neoplastic cells: quantitation and species specificity.

1983 • 51 citations

[5] Purification and characterization of tissue factor apoprotein

1976 • 49 citations

Fibrinogen kinetics in patients with neoplastic disease

1978 • 47 citations

Detection of Antigens of a New Diethylnitrosamine-Induced Transplantable Hepatoma by Delayed Hypersensitivity

1968 • 46 citations

Expression of cell-mediated hypersensitivity in vivo--recent advances.

1980 • 44 citations

Isolation of plasma membrane fragments and vesicles from ascites fluid of lymphoma-bearing mice and their possible role in the escape mechanism of tumors from host immune rejection

1978 • 44 citations

Block Copolymers

1973 • 43 citations

Fibrin deposits in Hodgkin's disease.

1982 • 40 citations

Warfarin Treatment of Mice Bearing Autochthonous Tumors: Effect on Spontaneous Metastases

1968 • 40 citations

The extract from the tissue of gastric cancer as procoagulant in disseminated intravascular coagulation syndrome

1977 • 38 citations

Interaction Between ‘Sensitized Lymphocytes’ and Antigen &lt;i&gt;in vitro&lt;/i&gt;

1972 • 38 citations

Data for Defining Fibrinogen and Its Plasmic Degradation Products

1975 • 37 citations

Characterization of the Coagulant Activity of Cultured Human Fibroblasts

1971 • 37 citations

Cancer cell procoagulant activity: Evaluation by an amidolytic assay

1980 • 37 citations

Pepstatin, an inhibitor of leukokinin formation and ascitic fluid accumulation.

1975 • 36 citations

Reed-Sternberg cells in Hodgkin's disease contain fibronectin

1981 • 34 citations

Proteinaceous precipitate in nodular (follicular) lymphomas

1973 • 34 citations

Lymphokines as Inflammatory Mediators

1979 • 34 citations

Clot forming and clot stabilizing enzymes from the mouse tumor YPC-1

1966 • 33 citations

Release of Cell-Surface Tumor-Associated Antigens by Viable Melanoma Cells From Humans2

1977 • 32 citations

Acute promyelocytic leukemiaA model for understanding the role of the malignant cell in hemostasis

1974 • 31 citations

Inhibition of lymphocyte protein synthesis by fibrinogen-derived peptides.

1982 • 28 citations

Thromboplastic activity of human ovarian tumours

1975 • 27 citations

Immune complex-induced human monocyte procoagulant activity. II. Cellular kinetics and metabolic requirements.

1982 • 26 citations

New Vasoconstrictor, Bovine Peptide B, released during Blood Coagulation

1967 • 25 citations

A proteolytic procoagulant associated with malignant transformation

1981 • 24 citations

Pathways of Blood Clotting Initiation by Cancer Cells

1979 • 24 citations

Tumor fluid thromboplastin activity

1968 • 24 citations

Suppressive effect of low molecular weight fibrinogen degradation products on human and rat lymphocytes

1978 • 23 citations

Intrafollicular hyalinosis and arterial hyalinosis of the spleen: Histochemical and immunofluorescence studies

1969 • 22 citations

Localization of intracranial tumors.Comparative study with131I-labeled antibody to human fibrinogen and neohydrin-203Hg

1967 • 22 citations

Rupture of the uterus after classical Caesarean section

1931 • 20 citations

Diffusible thromboplastins of human cancer and chorion tissue

1968 • 19 citations

Species Differences of Clotting Factors in Ox, Dog, Horse, and Man. Thromboplastin and Proconvertin

1957 • 18 citations

Tumor immunity in prognosis : the role of mononuclear cell infiltration

1982 • 18 citations

Quantitative study on thromboplastin in various strains of Yoshida ascites hepatoma cells of rat.

1974 • 17 citations

New Vasoconstrictor, Bovine Peptide-B, released during Blood Coagulation

1967 • 17 citations

Cancer Cell Procoagulant Activity

1979 • 16 citations

Thromboplastic and fibrinolytic properties of three transplantable rat tumours.

1970 • 16 citations

Comparative Studies on Blood Coagulation Factor XIII

1978 • 14 citations

Follicular lymphoma with deposits of amorphous hyaline material

1974 • 13 citations

Tissue factor in cultured cells: metabolic control.

1976 • 12 citations

Properties of leukokininogen isolated from human neoplastic ascites

1979 • 12 citations

Synthesis of Thromboplastin Protein by a Murine Macrophage-Like Cell Line

1982 • 12 citations

Leukokinin-forming system in the ascitic fluid of a murine mastocytoma

1973 • 11 citations

Immunohistochemical studies of antibodies in anti-Murphy lymphosarcoma sera.

1959 • 11 citations

Kininogenases of Blood Cells (Alternate Kinin Generating Systems)

1979 • 9 citations

Brief Communication: Presence of A-Type and Absence of C-Type Virus Particles in a Chemically Induced Guinea Pig Hepatoma

1974 • 9 citations

THROMBOPLASTIC AND FIBRINOLYTIC ACTIVITIES OF V2 AND V7 CARCINOMAS OF RABBIT, WITH SPECIAL REFERENCE TO FIBRIN DEPOSITION AND THROMBUS FORMATION IN THE TUMORS

1978 • 8 citations

THROMBOPHLEBITIS IN CANCER PATIENTS

1981 • 8 citations

Physical Stability of Cell Culture Procoagulants Detectable in First-Stage Coagulation Factor Assays

1972 • 7 citations

PLASMJN AND PLASMINOGEN ACTIVATORS: KINETICS, AND KINETICS OF PLASMINOGEN ACTIVATION

1981 • 7 citations

Leukokinins; their pharmacological properties and role in the pathology of fluid (ascites) accumulation

1978 • 6 citations

Murine tumor cell activity on in vitro hemostasis.

1976 • 5 citations

Pepstatin, an inhibitor of acid kininogenases and ascites retardant in neoplastic disease.

1979 • 5 citations

A factor with procoagulant activity produced by stimulated human leukocyte cultures

1980 • 4 citations

Leukokinin-H generated from human ascites fluid; its isolation and pharmacology

1979 • 3 citations

Renal disease.

1977 • 3 citations

Fibrin and cancer.

1971 • 2 citations

Fibrin and cancer.

1971 • 1 citations