The β-Adrenergic Receptor and its Mode of Coupling to Adenylate Cyclas

Multiple receptors for dopamine

1979 • 3,739 citations

FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE

1962 • 2,684 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method.

1974 • 1,130 citations

Handbook of Psychopharmacology

1978 • 1,034 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

The Pineal Gland: A Neurochemical Transducer

1974 • 872 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

GTP-binding proteins in membranes and the control of adenylate cyclase activity.

1977 • 456 citations

THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION.

1965 • 423 citations

Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptor.

1977 • 391 citations

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

1978 • 347 citations

Activation of pigeon erythrocyte membrane adenylate cyclase by guanylnucleotide analogues and separation of a nucleotide binding protein.

1975 • 337 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.

1979 • 308 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

Opiate-dependent modulation of adenylate cyclase.

1977 • 265 citations

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

1975 • 265 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

1976 • 240 citations

β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex

1976 • 238 citations

alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions.

1979 • 232 citations

Stereospecific [3H](−)-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase

1974 • 229 citations

β-Adrenergic Receptor: Stereospecific Interaction of Iodinated β-Blocking Agent with High Affinity Site

1974 • 229 citations

Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.

1977 • 216 citations

Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity

1978 • 202 citations

Adenylate cyclase activation by the .beta.-adrenergic receptors as a diffusion-controlled process

1979 • 199 citations

Fatty acids as modulators of membrane functions: catecholamine-activated adenylate cyclase of the turkey erythrocyte.

1975 • 187 citations

The control of adenylate cyclase by calcium in turkey erythrocyte ghosts.

1975 • 161 citations

Potassium Release Mediated by the Epinephrine α-Receptor in Rat Parotid Slices

1973 • 158 citations

Evidence for internalization of the recognition site of β-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol

1979 • 157 citations

Affinity chromatography of the beta-adrenergic receptor.

1979 • 156 citations

Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.

1977 • 156 citations

The Binding Characteristics and Number of β-Adrenergic Receptors on the Turkey Erythrocyte

1974 • 151 citations

beta-adrenergic receptors in rat liver: effects of adrenalectomy.

1976 • 150 citations

Noradrenaline binding and the search for catecholamine receptors

1974 • 144 citations

Guanine nucleotide‐controlled interactions between components of adenylate cyclase

1979 • 144 citations

Circadian cycles in binding of 3H-alprenolol to β-adrenergic receptor sites in rat pineal

1975 • 142 citations

Catecholamine binding to the beta-adrenergic receptor.

1977 • 134 citations

Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.

1975 • 133 citations

Alpha-Adrenergic Receptor Identification by [ ³ H]Dihydroergocryptine Binding

1976 • 130 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors

1979 • 129 citations

The effect of catecholamines and prostaglandins upon human and rat erythrocytes

1975 • 125 citations

Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity.

1976 • 124 citations

Uncoupling of Catecholamine Activation of Pigeon Erythrocyte Membrane Adenylate Cyclase by Filipin

1974 • 124 citations

Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states.

1977 • 113 citations

Reversal of Catecholamine Refractoriness by Inhibitors of RNA and Protein Synthesis

1974 • 111 citations

Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain.

1976 • 109 citations

Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.

1979 • 108 citations

Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

1977 • 104 citations

Coupling of a single adenylate cyclase of two receptors: adenosine and catecholamine

1978 • 102 citations

Modulation of the .beta.-receptor adenylate cyclase interactions in cultured Chang liver cells by phospholipid enrichment

1979 • 101 citations

Determination of the turn-off reaction for the hormone-activated adenylate cyclase.

1979 • 98 citations

Pineal β-Adrenergic Receptor: Diurnal Variation in Sensitivity

1974 • 96 citations

The functions of cyclic AMP and calcium as alternative second messengers in parotid gland and pancreas.

1975 • 93 citations

Synergistic activation of adenylate cyclase by guanylyl imidophosphate and epinephrine

1976 • 91 citations

Stereospecific Binding of Propranolol and Catecholamines to the β-Adrenergic Receptor

1974 • 91 citations

Hormone-receptor-adenylate cyclase interactions

1979 • 89 citations

Membrane Potential of Brown Adipose Tissue

1968 • 86 citations

Temperature‐induced interconversion of alpha‐and beta‐adrenoceptors in the frog heart.

1976 • 83 citations

The quantitative aspects of drug-receptor interactions.

1975 • 83 citations

Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.

1976 • 80 citations

THE ROLE OF ADENINE AND GUANINE NUCLEOTIDES IN THE ACTIVITY AND RESPONSE OF ADENYLATE CYCLASE SYSTEMS TO HORMONES: EVIDENCE FOR MULTI-SITE TRANSITION STATES

1974 • 77 citations

Comparison of the Lipolytic Activity of Circulating and Locally Released Noradrenaline during Acidosis

1974 • 74 citations

Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action.

1976 • 73 citations

The receptors concerned in the actions of catecholamines on glucose release, membrane potential and ion movements in guinea‐pig liver

1972 • 63 citations

Catecholamine receptors

2006 • 62 citations

Direct localisation of β-adrenoceptor sites in rat cerebellum by a new fluorescent analogue of propranolol

1976 • 59 citations

Ligand specificity and characteristics of the β-adrenergic receptor in turkey erythrocyte plasma membranes

1975 • 59 citations

Demonstration of Dopamine-sensitive Adenylate Cyclase in Malignant Neuroblastoma Cells and Change in Sensitivity of Adenylate Cyclase to Catecholamines in “Differentiated” Cells

1974 • 59 citations

Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

1975 • 58 citations

The role of GTP in the activation of adenylate cyclase

1977 • 54 citations

Tentative identification of β-adrenoreceptor subunits

1978 • 50 citations

Functional implantation of a solubilized β-adrenergic receptor in the membrane of a cell

1980 • 46 citations

The absence of desensitization in the beta adrenergic receptors of turkey reticulocytes and erythrocytes and its possible origin

1978 • 46 citations

Probing of β-adrenergic receptors by novel fluorescent β-adrenergic blockers

1977 • 44 citations

The Allosteric Inhibition by Calcium of Soluble and Partially Purified Adenylate Cyclase from Turkey Erythrocytes

1977 • 41 citations

β-ADRENERGIC STIMULATION OF PROTEIN CARBOXYMETHYLATION AND AMYLASE SECRETION IN RAT PAROTID

1979 • 39 citations

Temperature dependence of .beta. receptor, adenosine receptor, and sodium fluoride stimulated adenylate cyclase from turkey erythrocytes

1980 • 38 citations

Affinity label for beta-adrenergic receptor in turkey erythrocytes.

1976 • 37 citations

The interaction of catecholamines, Ca2+ and adenylate cyclase in the intact turkey erythrocyte

1975 • 35 citations

Photoaffinity labelling of the β-adrenergic receptors and receptor reserve for isoprenaline

1976 • 34 citations

The mode of coupling of adenylate cyclase to hormone receptors and its modulation by GTP

1978 • 33 citations

Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts

1977 • 33 citations

An irreversible blocker for the β-adrenergic receptor

1976 • 29 citations

Direct evidence for beta-adrenoreceptors on the Purkinje cells of mouse cerebellum

1977 • 29 citations

Synthesis of a photoaffinity probe for the beta-adrenergic receptor

1977 • 28 citations

Activation of turkey erythrocyte adenylate cyclase by two receptors: Adenosine and catecholamines

1977 • 27 citations

Temperature immutability of adenyl cyclase-coupled β adrenergic recptors

1974 • 27 citations

The mechanism of partial agonism in the beta-receptor dependent adenylate cyclase of turkey erythrocytes.

1979 • 23 citations

Ultrastructural probing of β‐adrenoreceptors on cell surfaces

1978 • 18 citations