Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Structure and Function of the CFTR Chloride Channel

1999 • 977 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties

1993 • 456 citations

Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis

1999 • 437 citations

Pathophysiology of Gene-Targeted Mouse Models for Cystic Fibrosis

1999 • 405 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Pharmacology of CFTR Chloride Channel Activity

1999 • 285 citations

ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator

1996 • 264 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein

1995 • 207 citations

Phosphorylation by Protein Kinase C Is Required For Acute Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Protein Kinase A

1997 • 204 citations

A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells

1990 • 169 citations

Phosphatase inhibitors activate normal and defective CFTR chloride channels.

1994 • 153 citations

Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein

1999 • 120 citations

Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Phenotypic Analysis of Cell Cultures of Human Tracheal Epithelium, Tracheobronchial Glands, and Lung Carcinomas

1993 • 117 citations

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

1999 • 113 citations

Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.

1993 • 92 citations

Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding.

1994 • 88 citations

Organic extraction of P i with isobutanol/toluene

1984 • 79 citations

Regulation of CFTR Cl ⁻ channel gating by ATP binding and hydrolysis

2000 • 76 citations

Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein

1999 • 61 citations

cAMP- and Ca2+-independent Activation of Cystic Fibrosis Transmembrane Conductance Regulator Channels by Phenylimidazothiazole Drugs

1996 • 52 citations

A recombinant polypeptide model of the second nucleotide‐binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase

1997 • 51 citations

Antisense oligonucleotide to PKC-ε alters cAMP-dependent stimulation of CFTR in Calu-3 cells

1998 • 48 citations

[27] Coupling factors from higher plants

1980 • 44 citations

ATP Hydrolysis by a CFTR Domain: Pharmacology and Effects of G551D Mutation

2000 • 43 citations

Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

2000 • 31 citations

Function and dysfunction of the CFTR chloride channel.

1995 • 30 citations