Downregulation of endothelin receptors by autocrine production of endothelin-1

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Binding and receptor down‐regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 215 citations

Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation

1991 • 211 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines.

1991 • 198 citations

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

1991 • 165 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

1990 • 161 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1

1990 • 158 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

Production of endothelin-1 by rat cultured mesangial cells

1990 • 108 citations

Specific binding of endothelin on human vascular smooth muscle cells in culture.

1989 • 103 citations

Endothelin-1 induces prostacyclin release from bovine aortic endothelial cells

1991 • 84 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein

1992 • 56 citations

Phosphoramidon inhibits the generation of endothelin‐1 from exogenously applied big endothelin‐1 in cultured vascular endothelial cells and smooth muscle cells

1991 • 49 citations

Endothelin-3 stimulates production of endothelium-derived nitric oxide via phosphoinositide breakdown

1991 • 47 citations

Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland

1992 • 44 citations

The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1–38] in conscious rats

1991 • 42 citations

Isolation, characterisation, growth and culture of endothelial cells from the rat aorta

1986 • 30 citations

In vitro degradation of endothelin-1 by endopeptidase 24.11 (enkephalinase)

1991 • 30 citations

Vascular A10 cell membranes contain an endothelin metabolizing neutral endopeptidase

1991 • 20 citations

Effects of dietary fat and adipose tissue location on insulin action in young boar adipocytes

1991 • 20 citations

Partial purification of phosphoramidon-sensitive endothelin converting enzyme in porcine aortic endothelial cells: High affinity for Ricinuscommunis agglutinin

1992 • 16 citations

Identification of endothelin converting enzyme in bovine lung membranes using a new fluorogenic substrate

1992 • 14 citations

Endothelin releasing activity in calf serum and porcine follicular fluid

1990 • 13 citations

Smooth Muscle Cells Contain a Factor Responsible for Decreasing Big Endothelin and Endothelin-1 Produced by Cultured Endothelial Cells

1991 • 12 citations

Human serum stimulates endothelin-1 synthesis more potently than prostacyclin production by cultured vascular endothelial cells

1991 • 10 citations