Vascular A10 cell membranes contain an endothelin metabolizing neutral endopeptidase

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

1990 • 247 citations

Studies on the enzymology of purified preparations of brush border from rabbit kidney

1973 • 212 citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

1990 • 187 citations

Membrane-bound kidney neutral metalloendopeptidase: interaction with synthetic substrates, natural peptides, and inhibitors

1983 • 170 citations

Similarities in mode and sites of action of sarafotoxins and endothelins

1989 • 152 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme

1990 • 142 citations

Specific binding of endothelin on human vascular smooth muscle cells in culture.

1989 • 103 citations

Conversion of porcine big endothelin to endothelin by an extract from the porcine aortic endothelial cells

1990 • 100 citations

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

1989 • 81 citations

Concomitant secretion of big endothelin and its C-terminal fragment from human and bovine endothelial cells

1989 • 57 citations

Endothelin binding sites in porcine‐aortic and rat lung membranes

1989 • 52 citations

Endothelin converting enzyme of bovine carotid artery smooth muscles

1991 • 47 citations

Evidence for pepstatin-sensitive conversion of porcine big endothelin-1 to endothelin-1 by the endothelial cell extract

1990 • 46 citations

Characterization of endothelin converting enzyme in rat lung

1990 • 34 citations