Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium.

Statistical principles in experimental design.

1962 • 27,228 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Molecular Basis of Visual Excitation

1968 • 1,002 citations

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle

1998 • 896 citations

Ageing and degeneration in the macular region: a clinico-pathological study.

1976 • 868 citations

Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice

1999 • 854 citations

Mutations in RPE65 cause autosomal recessive childhood–onset severe retinal dystrophy

1997 • 645 citations

Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.

1984 • 556 citations

THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RAT

1971 • 540 citations

Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat Chimeras

1976 • 534 citations

Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.

1989 • 482 citations

Retinal age pigments generated by self-assembling lysosomotropic detergents

1993 • 456 citations

Isolation and one-step preparation of A2E and iso -A2E, fluorophores from human retinal pigment epithelium

1998 • 454 citations

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR -mediated retinal and macular degeneration

2000 • 446 citations

Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies.

1978 • 394 citations

The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium.

1978 • 384 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro

1993 • 330 citations

Fluorophores of the human retinal pigment epithelium: Separation and spectral characterization

1988 • 299 citations

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

2000 • 273 citations

Circadian nature of rod outer segment disc shedding in the rat.

1980 • 204 citations

Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium

1986 • 146 citations

Rod outer segment disc shedding in relation to cyclic lighting

1976 • 123 citations

Deficiencies of vitamins E and A in the rat. Retinal damage and lipofuscin accumulation.

1980 • 121 citations

A QTL on distal Chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors

2000 • 118 citations

Age-related changes in the retinal pigment epithelium of pigmented rats

1984 • 110 citations

Lipofuscin accumulation resulting from senescence and vitamin E deficiency: Spectral properties and tissue distribution

1984 • 96 citations

Lipofuscin autofluorescence: Evidence for vitamin A involvement in the retina

1987 • 85 citations

Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes

1996 • 79 citations

Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment

1989 • 78 citations

THE ROLES OF VITAMIN E AND UNSATURATED FATTY ACIDS IN THE VISUAL PROCESS

1982 • 76 citations

AGE‐RELATED CHANGES IN THE FLUORESCENCE OF MELANIN and LIPOFUSCIN GRANULES OF THE RETINAL PIGMENT EPITHELIUM: A TIME‐RESOLVED FLUORESCENCE SPECTROSCOPY STUDY

1991 • 73 citations

Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium

1986 • 70 citations

[46] Genetic analysis of RPE65: From human disease to mouse model

2000 • 67 citations

Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium.

1989 • 65 citations

The Gene for the Retinal Pigment Epithelium-Specific Protein RPE65 Is Localized to Human 1p31 and Mouse 3

1994 • 65 citations

Vitamin A storage and peroxisomes in retinal pigment epithelium and liver.

1977 • 43 citations

Influence of dietary vitamin a on autofluorescence of leupeptin-induced inclusions in the retinal pigment epithelium

1992 • 42 citations

Iron-induced fluorescence in the retina: dependence on vitamin A.

1994 • 40 citations

Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats.

1991 • 36 citations

Photoreceptor Recovery in Retinoid-deprived Rats After Vitamin A Replenishment

1993 • 26 citations

Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium

1995 • 22 citations

Vitamin A and Lipofuscin

1987 • 13 citations

Long-term variations in cyclic light intensity and dietary vitamin A intake modulate lipofuscin content of the retinal pigment epithelium

1999 • 12 citations

The Microenvironment and Vision

1987 • 8 citations