Megakaryocyte Maturation and Platelet Release in Normal and Pathologic Conditions

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA

1964 • 1,062 citations

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

1985 • 886 citations

Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)

1985 • 752 citations

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

1982 • 698 citations

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

1982 • 655 citations

Platelets in Biology and Pathology

1981 • 644 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Albinism Associated with Hemorrhagic Diathesis and Unusual Pigmented Reticular Cells in the Bone Marrow: Report of Two Cases with Histochemical Studies

1959 • 539 citations

Induction of erythroid differentiation in the human leukaemia cell line K562

1979 • 470 citations

Platelet alpha-granule proteins: studies on release and subcellular localization

1979 • 451 citations

Hemostasis and Thrombosis, Basic Principles and Clinical Practice

1983 • 450 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.

1986 • 402 citations

Molecular Defects in Interactions of Platelets with the Vessel Wall

1984 • 381 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

Platelet alpha granules contain a growth factor for fibroblasts

1979 • 355 citations

Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features

1988 • 314 citations

Cholinesterase as a Possible Marker for Early Cells of the Megakaryocytic Series

1973 • 297 citations

Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules.

1980 • 293 citations

Growth of mouse megakaryocyte colonies in vitro.

1975 • 289 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 286 citations

Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts

1981 • 276 citations

Gray platelet syndrome

1971 • 276 citations

Biosynthesis of von Willebrand protein by human megakaryocytes.

1985 • 271 citations

Interaction of membrane systems in blood platelets.

1972 • 264 citations

An electron microscope study of the megacaryocyte of the rat bone marrow

1968 • 254 citations

Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).

1984 • 242 citations

Heterogeneity in storage pool deficiency: studies on granule-bound substances in 18 patients including variants deficient in alpha- granules, platelet factor 4, beta-thromboglobulin, and platelet-derived growth factor

1979 • 239 citations

Hereditary macrothrombocytopathia, nephritis and deafness

1972 • 238 citations

The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation

1976 • 230 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 220 citations

Congenital Gigantism of Peroxidase Granules

1954 • 217 citations

Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients

1982 • 209 citations

The growth of large megakaryocyte colonies from human bone marrow

1982 • 207 citations

Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase

1978 • 192 citations

Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro.

1987 • 191 citations

The Origin and Nature of the Blood Plates

1906 • 189 citations

Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes.

1981 • 188 citations

The histogenesis of the blood platelets

1910 • 186 citations

Platelets: Production, Function, Transfusion, and Storage.

1975 • 178 citations

Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells

1984 • 178 citations

STUDIES ON MICROPEROXISOMES V. ARE MICROPEROXISOMES UBIQUITOUS IN MAMMALIAN CELLS?

1973 • 177 citations

Two-factor requirement for murine megakaryocyte colony formation

1982 • 175 citations

THE FINE STRUCTURE OF THE MEGAKARYOCYTE IN THE MOUSE SPLEEN

1957 • 174 citations

The demarcation membrane system of the megakaryocyte: a misnomer?

1982 • 173 citations

The mechanism of platelet release

1980 • 171 citations

Ultrastructural studies of the gray platelet syndrome.

1979 • 169 citations

Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses.

1986 • 164 citations

Human megakaryocytes. I. Characterization of the membrane and cytoplasmic components of isolated marrow megakaryocytes.

1979 • 164 citations

Ultrastructural Localization of 5-Hydroxy-tryptamine in Blood Platelets

1966 • 163 citations

Electron microscopic observations on the membrane systems of the rat blood platelet

1967 • 163 citations

Immunological study of in vitro maturation of human megakaryocytes

1984 • 162 citations

A new hematologic syndrome with a distinct karyotype: the 5 q-- chromosome

1975 • 161 citations

Immunofluorescent identification of human megakaryocyte colonies using an antiplatelet glycoprotein antiserum

1981 • 159 citations

Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome

1988 • 159 citations

Ultrastructure of Human Bone Marrow Cell Maturation

1976 • 157 citations

Fechtner syndrome--a variant of Alport's syndrome with leukocyte inclusions and macrothrombocytopenia

1985 • 153 citations

An electron microscope study of the rat megacaryocyte

1969 • 151 citations

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies

1985 • 150 citations

The significance of megakaryocyte size

1982 • 148 citations

Acute Myelodysplasia with Myelofibrosis: a Report of Eight Cases

1981 • 147 citations

Localization of platelet prostaglandin production in the platelet dense tubular system.

1976 • 145 citations

Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction

1981 • 141 citations

Fechtner syndrome--a variant of Alport's syndrome with leukocyte inclusions and macrothrombocytopenia

1985 • 141 citations

Gray platelet syndrome: alpha-granule deficiency. Its influence on platelet function.

1981 • 141 citations

Recombinant murine granulocyte macrophage colony-stimulating factor has megakaryocyte colony-stimulating activity and augments megakaryocyte colony stimulation by interleukin 3.

1987 • 139 citations

Effects of recombinant human erythropoietin on megakaryocytes and on platelet production in the rat

1988 • 138 citations

Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17

1988 • 134 citations

Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation.

1988 • 132 citations

Defective alpha-granule production in megakaryocytes from gray platelet syndrome: ultrastructural studies of bone marrow cells and megakaryocytes growing in culture from blood precursors.

1981 • 131 citations

Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line

1987 • 130 citations

Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro

1987 • 129 citations

Migration of Entire Megakaryocytes through the Marrow‐Blood Barrier

1981 • 127 citations

Isolation of intact megakaryocytes from guinea pig femoral marrow. Successful harvest made possible with inhibitions of platelet aggregation; enrichment achieved with a two-step separation technique.

1976 • 127 citations

Human erythroleukemia cell line (HEL) undergoes a drastic macrophage- like shift with TPA

1983 • 126 citations

Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.

1988 • 122 citations

Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions

1984 • 118 citations

Megakaryocyte colony formation from human bone marrow precursors

1979 • 118 citations

Characteristics of bone marrow fibroblast colony-forming cells (CFU-F) and their progeny in patients with myeloproliferative disorders

1982 • 116 citations

Alpha-granule pool of glycoprotein IIb-IIIa in normal and pathologic platelets and megakaryocytes

1990 • 116 citations

Gray platelet syndrome: immunoelectron microscopic localization of fibrinogen and von Willebrand factor in platelets and megakaryocytes

1985 • 116 citations

Specific protein and glycoprotein deficiencies in platelets isolated from two patients with the gray platelet syndrome

1982 • 116 citations

Immunohistochemical localization of membrane and alpha-granule proteins in human megakaryocytes: application to plastic-embedded bone marrow biopsy specimens

1986 • 114 citations

Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics

1988 • 114 citations

Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters

1988 • 113 citations

Cytochemical localization of lysosomal enzymes in rat megakaryocytes and platelets.

1975 • 113 citations

Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line

1979 • 111 citations

The Blast Crisis of Chronic Granulocytic Leukaemia: Megakaryoblastic Nature of Cells as Revealed by the Presence of Platelet‐Peroxidase—A Cytochemical Ultrastructural Study

1978 • 107 citations

Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes.

1987 • 106 citations

Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen.

1979 • 106 citations

Expression of platelet proteins during the in vitro and in vivo differentiation of megakaryocytes and morphological aspects of their maturation.

1986 • 105 citations

Diagnostic significance of detecting pseudo-Pelger-Huet anomalies and micro-megakaryocytes in myelodysplastic syndrome

1986 • 105 citations

Flow cytometric analysis of normal human megakaryocytes

1988 • 104 citations

The Hermansky–Pudlak Syndrome

1985 • 104 citations

Ultrastructural localization of human platelet thrombospondin, fibrinogen, fibronectin, and von Willebrand factor in frozen thin section

1985 • 103 citations

Effects of recombinant human erythropoietin on megakaryocytes and on platelet production in the rat

1988 • 103 citations

Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface.

1987 • 102 citations

Distribution of Fibrinogen, and Platelet Factors 4 and XIII in Subcellular Fractions of Human Platelets

1975 • 100 citations

Atlas of Blood Cells. Function and Pathology.

1981 • 100 citations

Incorporation of a circulating protein into megakaryocyte and platelet granules.

1987 • 99 citations

Effect of human recombinant erythropoietin on human marrow megakaryocyte colony formation in vitro

1987 • 99 citations

Occurrence of Megakaryocytes in Various Vessels and Their Retention in the Pulmonary Capillaries in Man

1978 • 99 citations

Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL.

1988 • 98 citations

High doses of recombinant erythropoietin stimulate platelet production in mice.

1987 • 98 citations

Subcellular Localization of 5-Hydroxytryptamine and Histamine in Blood Platelets

1967 • 97 citations

Platelet function in the Chediak-Higashi syndrome

1976 • 97 citations

Megakaryocytopoiesis in Rats With Special Reference to Polyploidy

1970 • 97 citations

Thrombocytopoiesis--analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes.

1984 • 97 citations

Constitutive and inducible secretion of platelet-derived growth factor analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers.

1987 • 95 citations

Flow cytometric analysis of normal human megakaryocytes

1988 • 95 citations

Megakaryocyte colony formation from human bone marrow precursors

1979 • 94 citations

Ultrastructural features of abnormal blood platelets. A review.

1976 • 93 citations

Human megakaryocytic progenitors (CFU-M) assayed in methylcellulose: Physical characteristics and requirements for growth

1984 • 93 citations

Platelet glycoprotein IIb. Chromosomal localization and tissue expression.

1987 • 93 citations

Identification of primary lysosomes in human megakaryocytes and platelets

1982 • 93 citations

The Platelet Defect Associated with Albinism

1972 • 93 citations

Structure of the rat platelet factor 4 gene: a marker for megakaryocyte differentiation.

1987 • 93 citations

Uranaffin reaction: a new cytochemical technique for the localization of adenine nucleotides in organelles storing biogenic amines.

1977 • 91 citations

Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics.

1987 • 90 citations

Fate of senescent megakaryocytes in the bone marrow.

1983 • 88 citations

Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations

1988 • 86 citations

Phorbol diesters stimulate the development of an early murine progenitor cell. The burst-forming unit-megakaryocyte.

1985 • 86 citations

Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.

1988 • 85 citations

DNA Metabolism and Development of Organelles in Guinea-Pig Megakaryocytes: A Combined Ultrastructural, Autoradiographic and Cytophotometric Study

1970 • 84 citations

Congenital disorders of platelet function.

1980 • 83 citations

Platelet-derived collagenase inhibitor: characterization and subcellular localization.

1985 • 83 citations

Purification and partial characterization of a megakaryocyte colony-stimulating factor from human plasma.

1985 • 82 citations

Constitutive expression of platelet glycoproteins by the human leukemia cell line K562

1982 • 81 citations

Platelet function in the Chediak-Higashi syndrome

1976 • 81 citations

Immunoglobulin G is a platelet alpha granule-secreted protein.

1985 • 80 citations

Serotonin Deficiency and Prolonged Bleeding in Beige Mice

1976 • 79 citations

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: Its relationship to type β transforming growth factor (TGF‐β)

1988 • 78 citations

Biology of human megakaryocyte factor V

1986 • 78 citations

Biosynthesis of factor V in isolated guinea pig megakaryocytes.

1985 • 76 citations

May‐Hegglin Anomaly: A Defect in Megakaryocyte Fragmentation?

1974 • 76 citations

Rapid deactivation of NADPH oxidase in neutrophils: continuous replacement by newly activated enzyme sustains the respiratory burst

1988 • 75 citations

Immunocytochemical localization of fibrinogen, platelet factor 4, and beta thromboglobulin in thin frozen sections of human blood platelets.

1983 • 75 citations

The localization of calcium and phosphorus in human platelets

1974 • 75 citations

Cell-lineage antigens of the stem cell-megakaryocyte-platelet lineage are associated with the platelet IIb-IIIa glycoprotein complex

1985 • 75 citations

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function.

1987 • 74 citations

Uncoordinated expression of fibrinogen compared with thrombospondin and von Willebrand factor in maturing human megakaryocytes

1989 • 74 citations

Thrombopoietin: its biology, purification, and characterization.

1988 • 73 citations

Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase

1984 • 73 citations

New synthesis of a platelet-specific protein: platelet factor 4 synthesis in a megakaryocyte-enriched rabbit bone marrow culture system.

1983 • 72 citations

Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukaemia II. STUDIES WITH MONOCLONAL ANTIBODIES AND TERMINAL TRANSFERASE

1985 • 71 citations

Mouse megakaryocytes secrete acetylcholinesterase

1981 • 70 citations

Abnormal Platelet Function in Chediak‐Higashi Syndrome

1977 • 70 citations

Fine Structure and Peroxidase Activity of Circulating Micromegakaryoblasts and Platelets in a Case of Acute Myelofibrosis

1973 • 69 citations

Growth of human megakaryocyte colonies in culture from fetal, neonatal, and adult peripheral blood cells: ultrastructural analysis.

1979 • 69 citations

Cell surface phenotyping of megakaryoblasts

1987 • 68 citations

Myelofibrosis and acute megakaryoblastic leukemia in a child: Topographic relationship between fibroblasts and megakaryocytes with an α-granule defect

1982 • 68 citations

Origin of Pulmonary Megakaryocytes

1965 • 67 citations

Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma.

1987 • 67 citations

Acute megakaryoblastic leukaemia in children

1986 • 67 citations

Modest stimulatory effect of recombinant human GM-CSF on colony growth from peripheral blood human megakaryocyte progenitor cells.

1987 • 66 citations

Mepacrine, a tool for investigating the 5-hydroxytryptamine organelles of blood platelets by fluorescence microscopy.

1977 • 65 citations

Evidence that abnormal platelet functions in human Chédiak-Higashi syndrome are the result of a lack of dense bodies.

1983 • 65 citations

Purification of human megakaryocytes by fluorescence-activated cell sorting

1987 • 64 citations

The megakaryocyte in thrombocytopenia: A microscopic study which supports the theory that platelets are produced in the pulmonary circulation

1983 • 64 citations

Megakaryocyte morphogenesis stimulated in vitro by whole and partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation

1987 • 63 citations

Effect of recombinant and purified human haematopoietic growth factors on in vitro colony formation by enriched populations of human megakaryocyte progenitor cells

1988 • 63 citations

In vitro stimulation of megakaryocyte maturation by megakaryocyte stimulatory factor.

1987 • 63 citations

Origin of platelet-derived growth factor in megakaryocytes in guinea pigs.

1980 • 63 citations

Human megakaryocytes. V. Changes in the phenotypic profile of differentiating megakaryocytes.

1985 • 63 citations

Immunocytochemical Localization of Albumin and Factor XIII in Thin Cryo Sections of Human Blood Platelets

1984 • 62 citations

Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations

1988 • 62 citations

Electron microscopic and functional studies on platelets in gray platelet syndrome.

1984 • 61 citations

Emperipolesis of Granular Leukocytes within Megakaryocytes in Human Hemopoietic Bone Marrow

1970 • 61 citations

Erythroid properties of K562 cells

1983 • 61 citations

Colony formation by megakaryocytic progenitors in essential thrombocythaemia

1987 • 60 citations

Proplatelets and stress platelets

1987 • 60 citations

The Pulmonary Vessels as a Filter for Circulating Megakaryocytes in Rats

1974 • 60 citations

Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment

1986 • 60 citations

Platelets: production, function, transfusion, and storage

1974 • 58 citations

The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa

1987 • 58 citations

Dysplastic Platelets and Circulating Megakaryocytes in Chronic Myeloproliferative Diseases. II. Ultrastructure of Circulating Megakaryocytes

1974 • 57 citations

STORAGE OF 5-HYDROXYTRYPTAMINE IN MEGAKARYOCYTES

1972 • 55 citations

Metal ion contents of gel-filtered platelets from patients with storage pool disease

1975 • 55 citations

Megakaryocyte--platelet axis and the process of platelet formation and release

1980 • 55 citations

In vitro studies of megakaryocytopoiesis in thrombocytotic disorders of man

1983 • 54 citations

Reversal of acute ("malignant") myelosclerosis by allogeneic bone marrow transplantation

1982 • 54 citations

Congenital macrothrombocytopenia, leucocyte inclusions, deafness and proteinuria: functional and electron microscopic observations on platelets and megakaryocytes

1988 • 53 citations

Immature megakaryocytes in the mouse: In vitro relationship to megakaryocyte progenitor cells and mature megakaryocytes

1982 • 52 citations

Immature dense granules in platelets from mice with platelet storage pool disease

1987 • 52 citations

Identification of Circulating Micromegakaryocytes in a Case of Refractory Anemia: An Electron Microscopic-Cytochemical Study

1972 • 52 citations

Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.

1983 • 52 citations

Atypical Megakaryocytes in Preleukemic Phase of Acute Myeloid Leukemia

1973 • 51 citations

Optimal techniques for the immunocytochemical demonstration of?-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets

1984 • 51 citations

Separation of human megakaryocytes by state of differentiation on continuous gradients of Percoll: size and ploidy analysis of cells identified by monoclonal antibody to glycoprotein IIb/IIIa

1986 • 51 citations

The dense bodies of human platelets. Origin of serotonin storage particles from platelet granules.

1968 • 51 citations

Localization of 5‐Hydroxytryptamine in Blood Platelets: An Autoradiographic and Ultrastructural Study

1968 • 51 citations

Characterization of the blast cell population in two neonates with Down's syndrome and transient myeloproliferative disorder

1987 • 51 citations

Origin of megakaryocyte granules from Golgi vesicles

1960 • 50 citations

Immature dense granules in platelets from mice with platelet storage pool disease

1987 • 50 citations

Interrelationship between mitosis and endomitosis in cultures of human megakaryocyte progenitor cells [published erratum appears in Blood 1987 May;69(5):1547]

1987 • 50 citations

Animal model of human disease: Chédiak-Higashi syndrome.

1978 • 49 citations

CALCIUM-CONTAINING PLATELET GRANULES

1974 • 47 citations

A platelet abnormality in the Chediak-Higashi syndrome of man

1976 • 47 citations

Immunohistological comparison of platelet factor 4 (PF4), fibronectin (Fn) and factor VIII related antigen (VIIIR:Ag) in human platelet granules

1982 • 47 citations

Studies on a new variant of the Hermansky‐Pudlak syndrome: Qualitative, ultrastructural, and functional abnormalities of the platelet‐dense bodies associated with a phospholipase a defect

1978 • 46 citations

Clonal Expression of the Tn Antigen in Erythroid and Granulocyte Colonies and Its Application to Determination of the Clonality of the Human Megakaryocyte Colony Assay

1982 • 46 citations

Polyploid megakaryocytes develop randomly from a multicompartmental system of committed progenitors.

1982 • 46 citations

The c-sis gene expression in cells from a patient with acute megakaryoblastic leukemia and Down's syndrome

1987 • 45 citations

Fibrinogen biosynthesis in isolated guinea pig megakaryocytes

1985 • 45 citations

Studies on subcellular fractions of human plateless by the lactoperoxidase-iodination technique

1976 • 45 citations

Interrelationship between mitosis and endomitosis in cultures of human megakaryocyte progenitor cells [published erratum appears in Blood 1987 May;69(5):1547]

1987 • 44 citations

Human megakaryocytopoiesis: In vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers

1988 • 44 citations

Megakaryocyte fragments and the microtubule coil.

1987 • 44 citations

Ultrastructure of resting and activated storage pool deficient platelets from animals with the Chédiak-Higashi syndrome.

1982 • 43 citations

Hereditary nephritis, deafness and abnormal thrombopoiesis

1976 • 43 citations

THE MEGAKARYOCYTE BLOOD COUNT

1966 • 42 citations

Demarcation membrane system in rat megakaryocyte and the mechanism of platelet formation: a membrane reorganization process

1978 • 42 citations

The functional capacity of guinea pig megakaryocytes. I. Uptake of 3H-serotonin by megakaryocytes and their physiologic and morphologic response to stimuli for the platelet release reaction.

1977 • 42 citations

Effect of calcium and magnesium on binding of beta, gamma-methylene ATP to sarcoplasmic reticulum.

1977 • 41 citations

Reversal of marrow fibrosis in acute megakaryoblastic leukaemia after remission‐induction and consolidation chemotherapy followed by bone marrow transplantation

1983 • 41 citations

Application of flow cytometry and cell sorting to megakaryocytopoiesis

1979 • 41 citations

Gray platelet syndrome: Selective ?-granule deficiency and thrombocytopenia due to increased platelet turnover

1985 • 40 citations

Mepacrine Stains the Dense Bodies of Human Platelets and not Platelet Lysosomes

1981 • 40 citations

Recombinant gibbon interleukin‐3 stimulates megakaryocyte colony growth in vitro from human peripheral blood progenitor cells

1988 • 40 citations

Megakaryoblastic leukemia in an infant: Establishment of a megakaryocytic tumor cell line in athymic nude mice

1986 • 40 citations

Megakaryocyte--platelet axis and the process of platelet formation and release

1980 • 40 citations

Anti-HEL cell monoclonal antibodies recognize determinants that are also present in hemopoietic progenitors

1984 • 40 citations

Development of two distinct membrane systems associated in giant complexes in pathological megakaryocytes.

1975 • 39 citations

Megakaryoblastic transformation of chronic myelogenous leukemia

1982 • 39 citations

Origin and development of the demarcation system in megakaryocytes of rat bone marrow

1972 • 39 citations

Fibrinogen Associated with Subcellular Platelet Particles

1973 • 39 citations

The Hermansky-Pudlak syndrome: ultrastructure of bone marrow macrophages.

1973 • 39 citations

Analysis of phorbol ester stimulated human megakaryocyte development

1988 • 38 citations

Evaluation of bone marrow megakaryocyte ploidy distributions in persons with normal and abnormal platelet counts.

1988 • 38 citations

Grey platelet syndrome: studies on platelet alpha‐granules, lysosomes and defective response to thrombin

1987 • 38 citations

Fibrinogen synthesis by megakaryocyte rich human marrow cell concentrates

1985 • 38 citations

Philadelphia Chromosome–Positive Thrombocythemia and Megakaryoblast Leukemia

1987 • 37 citations

Sulfated proteoglycans and sulfated proteins in guinea pig megakaryocytes and platelets in vivo. Relevance to megakaryocyte maturation and platelet activation.

1988 • 37 citations

Ultrastructural demonstration of tubular inclusions coinciding with von Willebrand factor in pig megakaryocytes

1988 • 37 citations

Atlas of Blood Cells, Function and Pathology

1982 • 37 citations

Ultrastructure of rat megakaryocytes after prolonged thrombocytopenia

1977 • 36 citations

MORPHOLOGICAL AND BIOCHEMICAL CONFIRMATION OF GRAY PLATELET SYNDROME IN TWO SIBLINGS

1983 • 36 citations

Growth characteristics of circulating hematopoietic progenitor cells from patients with essential thrombocythemia

1988 • 35 citations

Isolation of human megakaryocytes by density centrifugation and counterflow centrigual elutriation.

1984 • 35 citations

Human platelet factor 4: Subcellular localization and characteristics of release from intact platelets

1980 • 35 citations

Modulation of megakaryocyte emperipolesis by phlebotomy: megakaryocytes as a component of marrow-blood barrier.

1986 • 35 citations

Characterization of human megakaryocyte colony-stimulating factor in the urinary extracts from patients with aplastic anemia and idiopathic thrombocytopenic purpura

1983 • 35 citations

Immunological characterization of the leukemic megakaryocytic line at light and electron microscopic levels

1984 • 33 citations

Megakaryoblastic leukemia in an infant: Establishment of a megakaryocytic tumor cell line in athymic nude mice

1986 • 33 citations

Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias.

1987 • 33 citations

The Wistar Furth rat: an animal model of hereditary macrothrombocytopenia

1988 • 33 citations

Megathrombocytopenia Associated with Glomerulonephritis, Deafness and Aortic Cystic Medianecrosis

1978 • 32 citations

Giant platelet granules in a child with the chediak‐higashi syndrome

1979 • 32 citations

Serotonin storage organelles in human megakaryocytes.

1971 • 31 citations

Megakaryocyte colony formation by bone marrow progenitors in myelodysplasia syndromes

1986 • 31 citations

An Electron Microscopic Study of the Bone Marrow of the Rat in an Experimental Myelogenous Leukemia

1972 • 31 citations

Circulating Megakaryocytes in Blood from the Antecubital Vein in Healthy, Adult Humans

1978 • 31 citations

Myeloproliferative Disorders Terminating in Acute Micromegakaryoblastic Leukaemia

1979 • 31 citations

Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.

1982 • 30 citations

Platelet peroxidase-positive blast cells in transient myeloproliferative disorder with Down's syndrome

1988 • 30 citations

Application of flow cytometry and cell sorting to megakaryocytopoiesis

1979 • 30 citations

Cytochemical profile of megakaryoblastic leukaemia: a study with cytochemical methods, monoclonal antibodies, and ultrastructural cytochemistry.

1987 • 30 citations

Absence of tubular structures and immunolabeling for von Willebrand factor in the platelet alpha-granules from porcine von Willebrand disease [published erratum appears in Blood 1987 Feb;69(2):707]

1986 • 30 citations

THE HISTOGENESIS OF BLOOD PLATELETS

1913 • 30 citations

Suppression of maturation of megakaryocyte colony forming unit in vitro by a platelet‐released glycoprotein

1987 • 30 citations

Thrombocytosis-induced suppression of small acetylcholinesterase- positive cells in bone marrow of rats

1979 • 30 citations

Ultrastructural localization of coagulation factor V in human platelets

1986 • 29 citations

EMPERIPOLESIS OF GRANULOCYTES WITHIN MEGAKARYOCYTES

1985 • 27 citations

Synthesis and localization of sulphated mucopolysaccharide in megakaryocytes and platelets of the rat, an analysis by electron-microscope autoradiography

1972 • 27 citations

Megakaryocyte Polyploidization in Acute Leukaemia and Preleukaemia

1974 • 27 citations

New insights into the regulation of human megakaryocytopoiesis.

1987 • 26 citations

A marker for megakaryocytes: serotonin accumulation in guinea pig megakaryocytes.

1981 • 26 citations

A monoclonal antibody to platelet glycoproteins IIb and IIIa complex: its use in purifying human megakaryocytes from sternal bone marrow aspirates for immunofluorescence studies of Ia-like antigens.

1983 • 25 citations

CFU-M-derived human megakaryocytes synthesize glycoproteins IIb and IIIa

1986 • 25 citations

Storage pool deficiency in cattle with the Chediak-Higashi syndrome results from an absence of dense granule precursors in their megakaryocytes

1988 • 25 citations

Megakaryoblastic transformation in myeloproliferative disorders

1984 • 24 citations

Megakaryocyte progenitors in the bone marrow and peripheral blood of patients with myeloproliferative diseases

1987 • 24 citations

Pulmonary platelet production: a physical analogue of mitosis?

1988 • 24 citations

Immunoelectron microscopic localization of platelet factor 4 and fibrinogen in the granules of human platelets.

1983 • 24 citations

Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.

1988 • 23 citations

Megakaryocytic colony formation in polycythaemia vera and secondary erythrocytosis

1988 • 23 citations

Effects of megakaryocyte colony-stimulating factor on terminal cytoplasmic maturation of human megakaryocytes.

1987 • 23 citations

Megakaryocyte and platelet ultrastructure in the Wistar Furth rat.

1988 • 23 citations

Acute Megakaryocytic Leukemia

1978 • 22 citations

Acetylcholinesterase in the platelet-megakaryocyte system. II. Structural localization in megakaryocytes of the rat, mouse, and cat.

1981 • 21 citations

Immuno-electron microscopical demonstration of lysosomes in human blood platelets and megakaryocytes using anti-cathepsin D

1985 • 21 citations

Megakaryocytopoiesis: incorporation of tritiated thymidine by small acetylcholinesterase-positive cells in murine bone marrow during antibody-induced thrombocytopenia

1987 • 19 citations

Immunohistochemical localization of membrane and alpha-granule proteins in plastic-embedded mouse bone marrow megakaryocytes and murine megakaryocyte colonies

1986 • 19 citations

Intracellular growth factors in polycythemia vera and other myeloproliferative disorders.

1987 • 18 citations

Antigenic differences between human platelets and megakaryocytes.

1987 • 18 citations

Selective uptake of [3H]arachidonic acid into the dense tubular system of human platelets

1987 • 17 citations

Identification of a light density murine megakaryocyte progenitor (LD- CFU-M)

1988 • 16 citations

Mepacrine Labelling Test and Uranaffin Cytochemical Reaction in Human Megakaryocytes

1982 • 16 citations

Expression of myeloid-specific antigens on two human erythroleukaemia cell lines, HEL and K562

1984 • 16 citations

Analysis of human hemopoietic progenitor cells for the expression of glycoprotein IIIa.

1988 • 16 citations

Chromosomal Localization and Tissue Expression

1987 • 16 citations

Growth factor production by a human megakaryocytic tumor cell line

1988 • 14 citations

Precursors of monoamine-storage organelles in developing megakaryocytes of the rat

1983 • 14 citations

Phenotypes of blasts in acute erythroblastic and megakaryoblastic leukemia - Review.

1987 • 13 citations

Interaction of ristocetin and bovine plasma with guinea pig megakaryocytes: a means to enrich megakaryocytes based on membrane rather than physical characteristics

1987 • 12 citations

Abnormalities of Granulocytes and Megakaryocytes in Preleukemic Syndromes

1979 • 10 citations

Evidence that platelets are produced in the pulmonary circulation by a physical process.

1986 • 9 citations

Leukaemoid reaction with megakaryocytic features in newborns with Down's syndrome

1988 • 8 citations

Megakaryocytic Leukaemia as a Phase of Myeloproliferative Disorders

1982 • 8 citations

Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase

1978 • 7 citations

Polycyth�mia vera: Elektronenmikroskopische Befunde am Knochenmark von zehn unbehandelten Patienten

1979 • 7 citations

The role of erythropoietin, megakaryocyte colony-stimulating factor, and T-cell-derived factors on human megakaryocyte colony formation: evidence for T-cell-mediated and T-cell-independent stem cell proliferation.

1987 • 7 citations

Diploid and tetraploid precursors of megakaryocytes in normal human bone marrow detected by immunofluorescence

1987 • 6 citations

Platelet peroxidase deficiency in a case of myelodysplastic syndrome with myelofibrosis.

1983 • 5 citations

Serotonin uptake by progeny of murine megakaryocyte precursors (CFU-M) in vitro.

1984 • 5 citations

Serotonin incorporation as a marker of murine megakaryocyte proliferation in liquid cultures.

1988 • 5 citations

Cytochemical demonstration of ‘platelet’ peroxidase at the light microscope level

1987 • 4 citations

Acquired refractory anaemia with excess of blasts of promegakaryoblastic type

1986 • 3 citations

Deleted Work

1955 • 0 citations