Arachidonic Acid Transformation and Tumor Production

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

1970 • 981 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

1977 • 797 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Regulation of the immune response by prostaglandins

1980 • 772 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

1978 • 715 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

1976 • 573 citations

Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

1977 • 573 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.

1978 • 489 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Prostaglandins as Mediators of Hypercalcemia Associated with Certain Types of Cancer

1975 • 461 citations

Structure of slow-reacting substance of anaphylaxis from guinea-pig lung

1980 • 426 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Control of lymphokine secretion by prostaglandins

1976 • 415 citations

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

1975 • 393 citations

N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat.

1979 • 388 citations

EVIDENCE THAT THE BONE RESORPTION-STIMULATING FACTOR PRODUCED BY MOUSE FIBROSARCOMA CELLS IS PROSTAGLANDIN E2

1972 • 379 citations

Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae.

1968 • 376 citations

Accumulation of Cyclooxygenase Products of Arachidonic Acid Metabolism in Gerbil Brain During Reperfusion After Bilateral Common Carotid Artery Occlusion

1980 • 367 citations

The Wider World

1974 • 358 citations

Subversion of immune system by tumor cells and role of prostaglandins.

1975 • 355 citations

PROSTAGLANDIN SECRETION BY MEDULLARY CARCINOMA OF THE THYROID

1968 • 353 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

1980 • 301 citations

Tumor-promoting Agents in Two-stage Carcinogenesis1

2015 • 296 citations

Stimulation and Blockade of Prostaglandin Biosynthesis

1971 • 286 citations

Nonparathyroid Humoral Hypercalcemia in Patients with Neoplastic Diseases

1973 • 285 citations

SIGNIFICANCE OF PHOSPHOLIPASE A FOR PROSTAGLANDIN FORMATION

1971 • 282 citations

Stimulation of bone resorption by various prostaglandins in organ culture

1975 • 275 citations

Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.

1980 • 274 citations

Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria

1978 • 271 citations

Corticosteroids inhibit prostaglandin production by rheumatoid synovia

1975 • 261 citations

Specificities of Prostaglandins B1, F1α, and F2α Antigen-Antibody Reactions

1971 • 260 citations

Prostaglandin Suppression of Mitogen-Stimulated Lymphocytes In Vitro

1978 • 258 citations

Age and Sleep

1964 • 254 citations

Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids

1975 • 239 citations

Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.

1977 • 234 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 233 citations

PROSTAGLANDINS IN AMINE-PEPTIDE-SECRETING TUMOURS

1968 • 208 citations

Prostaglandins from tumours of human large bowel

1977 • 202 citations

Inhibition of tumour growth in vivo and in vitro by prostaglandin E

1976 • 196 citations

Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.

1978 • 196 citations

The Inhibition by Aspirin and Indomethacin of Osteolytic Tumour Deposits and Hypercalcaemia in Rats with Walker Tumour, and its Possible Application to Human Breast Cancer

1973 • 194 citations

Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase

1978 • 193 citations

Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells

1980 • 192 citations

Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells.

1977 • 188 citations

Prostaglandins and cancer: An update

1974 • 188 citations

Pharmacological control of prostaglandin and thromboxane release from macrophages

1978 • 187 citations

Prostaglandins in Hematology

1974 • 186 citations

Hypercalcemia and tumor-prostaglandins: The VX2 carcinoma model in the rabbit

1975 • 185 citations

Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

1980 • 185 citations

Antigen stimulation of prostaglandin synthesis and control of immune responses.

1976 • 184 citations

Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells

1975 • 184 citations

Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins

1976 • 183 citations

Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.

1977 • 183 citations

Stimulation of bone resorption by various prostaglandins in organ culture

1975 • 181 citations

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187

1977 • 178 citations

Mechanism of inhibition of tumour growth by aspirin and indomethacin

1978 • 178 citations

Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption

1974 • 176 citations

Prostaglandins and the immune response

1977 • 176 citations

Prostaglandin production by mouse fibrosarcoma cells in culture: Inhibition by indomethacin and aspirin

1972 • 166 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).

1978 • 160 citations

The action of prostaglandin synthetase on 2-arachidonyl-lecithin

1968 • 160 citations

Indomethacin-Responsive Hypercalcemia in a Patient with Renal-Cell Adenocarcinoma

1974 • 159 citations

Alteration of tumor growth by aspirin and indomethacin: Studies with two transplantable tumors in mouse

1976 • 157 citations

Effects of phorbol-12,13-diesters on prostaglandin production and phospholipase activity in canine kidney (MDCK) cells

1977 • 155 citations

Prostaglandin synthesis by fetal rat bone in vitro: Evidence for a role of prostacyclin

1979 • 155 citations

Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA

1980 • 147 citations

Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes.

1978 • 146 citations

The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

1972 • 145 citations

Stimulation of prostaglandin synthesis by tumor-promoting phorbol-12, 13-diesters in canine kidney (MDCK) cells. Cycloheximide inhibits the stimulated prostaglandin synthesis, deacylation of lipids, and morphological changes

1978 • 142 citations

Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.

1979 • 139 citations

BREAST CANCER, PROSTAGLANDINS, AND BONE METASTASES

1975 • 136 citations

Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator

1980 • 134 citations

Cocarcinogenesis and biological effects of tumor promoters.

1982 • 133 citations

Ionophores stimulate prostaglandin and thromboxane biosynthesis

1977 • 133 citations

The relationship between concentration of prostaglandin E and rates of cell replication

1974 • 133 citations

Epidermal growth factor stimulates prostaglandin biosynthesis by canine kidney (MDCK) cells

1977 • 133 citations

Plasminogen activator in chick fibroblasts: Induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester

1978 • 132 citations

Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids

1976 • 132 citations

Endogenous prostaglandins and osmotic water flow in the toad bladder

1972 • 131 citations

Biological activities of prostaglandin analogues and metabolites on bone in organ culture

1977 • 128 citations

Effect of prostaglandin endoperoxides and metabolites on bone resorption in vitro

1977 • 125 citations

Prostaglandins: Physiological Pharmacological and Pathological Aspects

1976 • 120 citations

The mobilization of arachidonic acid in platelets exposed to thrombin or ionophore A23187. Effects of adenosine triphosphate deprivation.

1977 • 119 citations

Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.

1977 • 117 citations

Prostaglandin E-mediated mitogenic stimulation of mouse epidermis in vivo by divalent cation ionophore A 23187 and by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1981 • 110 citations

Review: Prostaglandins and cancer

1980 • 110 citations

Role of 3′,5′ -Adenosine Monophosphate in Regulation of Morphology and Growth of Transformed and Normal Fibroblasts

1972 • 109 citations

Enhancement of natural and antibody-dependent lymphocyte cytotoxicity by drugs which inhibit prostaglandin production by tumor target cells

1978 • 108 citations

Determination of cyclooxygenase products and prostaglandin metabolites using high-pressure liquid chromatography and radioimmunoassay

1979 • 108 citations

Biochemical Aspects of Prostaglandins and Thromboxanes

1977 • 107 citations

ANTICONVULSANTS AND FETAL MALFORMATIONS

1976 • 106 citations

Prostaglandin synthesis inhibition: Effect on bone changes and sarcoma tumor induction in balb/c mice

1975 • 104 citations

The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells.

1981 • 104 citations

Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.

1977 • 103 citations

Tumor Growth Inhibition and Potentiation of Immunotherapy by Indomethacin in Mice<xref ref-type="fn" rid="FN1">2</xref>

1979 • 102 citations

Retinoic acid inhibition of the comitogenic action of mezerein and phorbol esters in bovine lymphocytes.

1978 • 99 citations

Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma

1973 • 97 citations

Indomethacin inhibition of cell proliferation induced by the phorbolester TPA is reversed by prostaglandin E2 in mouse epidermis in vivo

1978 • 97 citations

Cancer growth, response to treatment and survival time in mice: Beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen

1979 • 97 citations

Enhancement of carcinogenesis by prostaglandins

1978 • 96 citations

Retinoids as well as tumour promoters enhance deacylation of cellular lipids and prostaglandin production in MDCK cells

1978 • 95 citations

Prostaglandins E and F in Endocrine Diarrheagenic Syndromes

1976 • 94 citations

Fluocinolone acetonide: A potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis

1977 • 93 citations

Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.

1979 • 92 citations

A Re-evaluation of the Concept of Cocarcinogenesis

2015 • 85 citations

Change in growth and morphology of fibroblasts by prostaglandins.

1971 • 84 citations

Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187

1980 • 82 citations

Stimulation of prostaglandin production in bone by phorbol diesters and melittin

1978 • 82 citations

Intravenous Infusion of Prostaglandin E₂Raises Plasma Calcium Concentration in the Rat*

1975 • 81 citations

Plasma prostaglandins in hypercalcemic patients with neoplastic disease

1977 • 81 citations

Elevated levels of prostaglandin E2 in Yoshida hepatoma and the inhibition of tumour growth by non-steroidal anti-inflammatory drugs

1980 • 80 citations

Prostaglandins: Physiological, Pharmacological and Pathological Aspects.

1977 • 80 citations

Arachidonic acid metabolism by cells in culture: analyses of culture fluids for cyclooxygenase products by radioimmunoassay before and after separation by high pressure liquid chromatography

1979 • 77 citations

Partial characterization of a prostaglandin-induced suppressor factor

1980 • 76 citations

Elevated Prostaglandins and Suppressed Parathyroid Hormone Associated with Hypercalcemia and Renal Cell Carcinoma

1975 • 76 citations

Specificity of phospholipases in methylcholanthrene-transformed mouse fibroblasts activated by bradykinin, thrombin, serum, and ionophore A23187.

1979 • 75 citations

Prostaglandin: Increased Production by Renal Cell Carcinoma

1977 • 75 citations

Human breast tumour-induced osteolysis and prostaglandins

1976 • 72 citations

Role of prostaglandins in the production of hypercalcemia by tumors.

1978 • 71 citations

Cyclooxygenase products of arachidonic acid metabolism by mouse bone in organ culture

1980 • 71 citations

Prostaglandins: Chemical and Biochemical Aspects

1976 • 69 citations

Memorandum on B. C. G.; a British review.

1946 • 66 citations

Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblasts.

1978 • 65 citations

Indomethacin enhancement of spleen‐cell responsiveness to mitogen stimulation in tumorous mice

1976 • 64 citations

Effects of phorbol ester tumor promoters on arachidonic acid metabolism in chick embryo fibroblasts.

1979 • 64 citations

Arachidonic acid and prostaglandin E2 release and enhanced cell proliferation induced by the phorbol ester TPA in a murine epidermal cell line

1981 • 64 citations

Prostaglandins and cyclic nucleotides in moloney sarcoma tumors

1974 • 63 citations

Tumor-mediated immunosuppression: Prevention by inhibitors of prostaglandin synthesis

1977 • 62 citations

Prostaglandin-E2-9-ketoreductase in rabbit kidney

1975 • 62 citations

Inflammatory, tumor initiating and promoting activities of polycyclic aromatic hydrocarbons and diterpene esters in mouse skin as compared with their prostaglandin releasing potency in vitro

1978 • 61 citations

Prostaglandin production by type II alveolar epithelial cells

1979 • 61 citations

Prostaglandin-mediated hypercalcemia in the VX2 carcinoma-bearing rabbit

1977 • 60 citations

Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3. Requirement for protein synthesis.

1977 • 59 citations

Effects of retinoic acid and juvenile hormone on the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate.

1978 • 59 citations

Prostaglandin E and cancer Growth

1980 • 57 citations

Prostaglandin mediation of collagenase-induced bone resorption

1976 • 56 citations

Altered lipid microviscosity in lymphoblastoid cells treated with 12‐O‐tetradecanoyl phorbol 13‐acetate, a tumor promoter

1979 • 52 citations

Relationships, among the steroids, of anti-inflammatory properties and inhibition of prostaglandin production and arachidonic acid release by transformed mouse fibroblasts.

1977 • 52 citations

Ionophore A23187 raises cyclic AMP levels in macrophages by stimulating prostaglandin E formation

1979 • 51 citations

The Effect of Cortisone on Chemical Carcinogenesis in the Mouse Skin

1954 • 49 citations

Multiple effects of dexamethasone on protein synthesis and hyperplasia caused by a tumor promoter.

1973 • 49 citations

Practical Applications of Prostaglandins and their Synthesis Inhibitors

1979 • 49 citations

The use of immobilized ligands and [125I] protein a for immunoassays of thromboxane B2, prostaglandin D2, 13,14-dihydro-prostaglandin E2, 5,6-dihydro-prostaglandin I2, 6-keto-prostaglandin F1α, 15-hydroxy-9α,11α(epoxymethano)prosta5, 13-dienoic acid and 15-hydroxy-11α,9α(epoxymethano)prosta-5,13-dienoic acid

1979 • 48 citations

Effects of indomethacin on moloney sarcoma virus-induced tumors

1974 • 46 citations

Initiation of Bone Resorption by the Classical and Alternative C Pathways and Its Mediation by Prostaglandins

1977 • 46 citations

Multiple molecular forms of prostaglandin 15-hydroxydehydrogenase and 9-ketoreductase in chicken kidney

1977 • 46 citations

Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin E2 in rabbits bearing the VX2 carcinoma: Effects of hydrocortisone and indomethacin

1977 • 45 citations

Enhancement of anti-cancer activity of cytotoxic chemotherapy with protection of normal tissues by inhibition of P.G. synthesis

1978 • 43 citations

Practical Applications of Prostaglandins and Their Synthesis Inhibitors.

1980 • 43 citations

Biochemical aspects of prostaglandins and thromboxanes

1981 • 42 citations

Bone Resorption in Vitro and in Vivo in PGE-Treated Mice

1977 • 42 citations

Antihypertensive Function of a Renal-Cell Carcinoma

1974 • 40 citations

Direct immunochemical detection of prostaglandin-e and cyclic nucleotides in human malignant tumors

1977 • 39 citations

Vasoactive substances in Kaposi's sarcoma

1971 • 39 citations

Prostaglandins: Effect on plasma calcium concentration

1973 • 39 citations

Stimulation of the release of prostaglandins from polymorphonuclear leukocytes by the calcium ionophore A23187

1978 • 38 citations

Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma.

1978 • 38 citations

Effects of hydrocortisone on the hypercalcemia and plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in mice bearing the HSDM1 fibrosarcoma

1977 • 38 citations

Prostaglandins and cancer

1976 • 36 citations

Prostaglandins and Hypercalcemic States

1978 • 36 citations

Effect of indomethacin on blastogenesis of lymphocytes from cancer patients: Differentiation of patient types

1979 • 36 citations

α-Tocopherol inhibits 12−O-tetradecanoylphorbol-13-acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of madin-darby canine kidney cells

1980 • 35 citations

Humoral similarities of carcinoid tumors and medullary carcinomas of the thyroid.

1973 • 32 citations

Induction of plasminogen activator and prostaglandin biosynthesis in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate.

1980 • 30 citations

Tumor promoting phorbol diesters stimulate release of radioactivity from [3H]-arachidonic acid labeled- but not [14C]linoleic acid labeled-cells. Indomethacin inhibits the stimulated release from [3H]arachidonate labeled cells

1978 • 30 citations

University News

1972 • 30 citations

Stimulation by carcinogens and promoters of prostaglandin production by dog kidney (MDCK) cells in culture.

1978 • 29 citations

N-(4-hydroxyphenyl)retinamide: a synthetic analog of vitamin A that is a potent inhibitor of prostaglandin biosynthesis

1980 • 24 citations

A radioimmunoassay for 6-keto-prostaglandin F1 alpha.

1980 • 24 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-accelerated phospholipid metabolism by 5,8,11,14-eicosatetraynoic acid.

1980 • 24 citations

Use of inhibitors of prostaglandin synthesis in patients with breast cancer.

1980 • 24 citations

On the molecular structure of receptors for co-carcinogens and some anti-cancer drugs

1975 • 21 citations

Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats

1977 • 20 citations

Analysis by high performance liquid chromatography of cyclooxygenase products of arachidonic acid metabolism in plasma of rabbits bearing the VX2 carcinoma

1980 • 15 citations

Human breast carcinomas release prostaglandin-like material into the blood.

1980 • 13 citations

BENIGN BREAST LESIONS AND OSTEOLYSIS

1976 • 12 citations

The site of VX2 tumor transplantation affects the development of hypercalcemia in rabbits

1980 • 12 citations

Prostaglandins and their relationships to malignant and benign human breast tumors.

1980 • 11 citations

Inhibition of lymphoma cell proliferation by supernatant from fibrosarcoma cultures: Preliminary evidence that the inhibitory material is prostaglandin E

1977 • 10 citations

Regulation of phospholipase activity in platelets.

1978 • 10 citations

Prostaglandins in neural crest-tumours

1975 • 9 citations

Prostaglandins in neural crest-tumours

1975 • 9 citations

Prostaglandin production and metabolism in human breast cancer.

1980 • 9 citations

Prostacyclin potently resorbs bone in vitro.

1980 • 8 citations

Improved anticancer effect by combining cytotoxic drugs with an inhibitor of prostaglandin synthesis.

1980 • 6 citations

Stimulation by ionophore A₂₃₁₈₇and carbamylcholine of prostaglandins release from the thyroid glandin vitro

1977 • 5 citations

Tumor promoter 12-O-tetradecanoylphorbol-13-acetate is not a prostaglandin E-type agonist

1979 • 5 citations

Perioperative behavior of prostaglandin E2 and 13,14-dihydro-15-keto-PGF2 alpha in serum of bronchial carcinoma patients.

1980 • 5 citations