Early aldosterone action: toward filling the gap between transcription and transport

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1996 • 2,002 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Nongenomic actions of steroid hormones

2003 • 944 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Epithelial sodium channel regulated by aldosterone-induced protein sgk

1999 • 728 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

SPECIFIC, NONGENOMIC ACTIONS OF STEROID HORMONES

1997 • 663 citations

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

1988 • 576 citations

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

1998 • 545 citations

An epithelial serine protease activates the amiloride-sensitive sodium channel

1997 • 509 citations

Mineralocorticoid and Glucocorticoid Receptor Activities Distinguished by Nonreceptor Factors at a Composite Response Element

1993 • 461 citations

Renal potassium transport: mechanisms and regulation

1998 • 341 citations

GLUCOCORTICOID AND MINERALOCORTICOID RECEPTORS: Biology and Clinical Relevance

1997 • 313 citations

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

1993 • 299 citations

Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS

1994 • 285 citations

Aldosterone-induced increase in the abundance of Na+ channel subunits

1996 • 257 citations

Steroid receptor heterodimerization demonstrated in vitro and in vivo.

1995 • 242 citations

Localization and regulation by steroids of the ?, ? and ? subunits of the amiloride-sensitive Na+ channel in colon, lung and kidney

1995 • 233 citations

Regulation of Na channels of the rat cortical collecting tubule by aldosterone.

1993 • 208 citations

Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells.

1997 • 192 citations

Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.

1993 • 190 citations

Specific DNA Binding of Stat5, but Not of Glucocorticoid Receptor, Is Required for Their Functional Cooperation in the Regulation of Gene Transcription

1997 • 184 citations

Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia

1992 • 183 citations

A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.

1995 • 181 citations

Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions

1997 • 179 citations

Antagonism in the humanmineralocorticoid receptor

1998 • 171 citations

In vivo phosphorylation of the epithelial sodium channel

1998 • 168 citations

Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver.

1996 • 152 citations

Transcriptional control of sodium transport in tight epithelia by adrenal steroids

1995 • 151 citations

Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance.

1996 • 149 citations

Noncoordinate regulation of epithelial Na channel and Na pump subunit mRNAs in kidney and colon by aldosterone

1997 • 147 citations

Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia

1997 • 133 citations

Rapid Cardiovascular Action of Aldosterone in Man1

1998 • 123 citations

Methylation Increases Sodium Transport into A6 Apical Membrane Vesicles: Possible Mode of Aldosterone Action

1984 • 121 citations

Modulation of Cytosolic Protein Kinase C and Calcium Ion Activity by Steroid Hormones in Rat Distal Colon

1996 • 109 citations

Regulation of sodium transport by steroid hormones.

1998 • 102 citations

Aldosterone Induces a Rapid Increase in the Rate of Na,K-ATPase Gene Transcription in Cultured Kidney Cells

1989 • 97 citations

in vitro及びin vivoで示されるステロイド受容体ヘテロ二量化

1995 • 83 citations

Amiloride-sensitive Na channels

1998 • 82 citations

Ras Pathway Activates Epithelial Na⁺Channel and Decreases Its Surface Expression inXenopusOocytes

1998 • 82 citations

Early effects of aldosterone on apical and basolateral membrane conductances of TBM cells

1992 • 77 citations

Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface.

1996 • 70 citations

Modulation of Human Mineralocorticoid Receptor Function by Protein Kinase A

1999 • 69 citations

Receptor occupancy vs. induction of Na+-K+-ATPase and Na+ transport by aldosterone

1985 • 67 citations

Aldosterone regulation of Na+ transport and Na+-K+-ATPase in A6 cells: role of growth conditions

1987 • 66 citations

Steroid hormone stimulation of Na+ transport in A6 cells is mediated via glucocorticoid receptors

1993 • 63 citations

Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins.

1997 • 60 citations

Carboxylmethylation of the β Subunit of xENaC Regulates Channel Activity

1998 • 58 citations

Regulation of distal nephron K⁺ channels (ROMK) mRNA expression by aldosterone in rat kidney

1998 • 56 citations

Cellular responses to steroids in the enhancement of Na+ transport by rat collecting duct cells in culture. Differences between glucocorticoid and mineralocorticoid hormones.

1992 • 53 citations

Aldosterone action: induction of p21 ^ras andfra-2 and transcription-independent decrease inmyc,jun, andfos

1999 • 52 citations

Time-dependent stimulation by aldosterone of blocker-sensitive ENaCs in A6 epithelia

1998 • 45 citations

Corticosteroid regulation of renal Na,K-ATPase.

1996 • 45 citations

The role of 11β-hydroxysteroid dehydrogenase in steroid hormone specificity

1998 • 40 citations

Aldosterone induces early activation and late accumulation of Na-K-ATPase at surface of A6 cells

1994 • 35 citations

Basolateral Na⁺ pump modulates apical Na⁺ and K⁺ conductances in rabbit cortical collecting ducts

1999 • 35 citations

Dexamethasone enhances expression of mitochondrial oxidative phosphorylation genes in rat distal colon

1995 • 35 citations

Early Aldosterone Effects

1998 • 31 citations

S-Adenosyl-l-homocysteine Hydrolase Regulates Aldosterone-induced Na+ Transport

1999 • 30 citations

A reappraisal of aldosterone effects on the kidney: new insught provided by epithelial sodium channel cloning

1997 • 28 citations

Aldosterone modulates sodium kinetics of Na,K-ATPase containing an alpha 1 subunit in A6 kidney cell epithelia.

1995 • 28 citations

The Rat Glucocorticoid Receptor Mutant K461A Differentiates between Two Different Mechanisms of Transrepression

1997 • 27 citations

Polarized membrane movements in a6 kidney cells are regulated by aldosterone and vasopressin/vasotocin

1993 • 19 citations

Early effects of aldosterone on the basolateral potassium conductance of A6 cells

1993 • 17 citations

Regulation of Na⁺ pump function by aldosterone is α‐subunit isoform specific

1999 • 14 citations

Guanine nucleotide binding proteins in cultured renal epithelia: studies with pertussis toxin and aldosterone

1999 • 3 citations