A Dictyostelium discoideum mutant that missorts and oversecretes lysosomal enzyme precursors is defective in endocytosis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

Trafficking of lysosomal enzymes in normal and disease states.

1986 • 445 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting.

1988 • 409 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues.

1980 • 404 citations

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

1981 • 323 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

The role of intermediate vesicles in the adsorptive endocytosis and transport of ligand to lysosomes by human fibroblasts.

1983 • 196 citations

Two yeast mutants defective in endocytosis are defective in pheromone response

1986 • 164 citations

A single mutation in Chinese hamster ovary cells impairs both Golgi and endosomal functions.

1984 • 120 citations

Structural analysis of the asparagine-linked oligosaccharides from three lysosomal enzymes of Dictyostelium discoideum. Evidence for an unusual acid-stable phosphodiester.

1983 • 111 citations

Secretion of Lysosomal enzymes in the cellular slime mold, Dictyostelium discoideum.

1981 • 109 citations

Isolation of mutations in Dictyostelium discoideum affecting α-mannosidase

1975 • 95 citations

Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins.

1984 • 93 citations

Sulfated N-linked oligosaccharides in mammalian cells. I. Complex-type chains with sialic acids and O-sulfate esters.

1988 • 90 citations

Structural analysis of N-linked oligosaccharides from glycoproteins secreted by Dictyostelium discoideum. Identification of mannose 6-sulfate.

1986 • 90 citations

Functional heterogeneity of monoclonal antibodies obtained using different screening assays

1983 • 89 citations

Specific proteolysis regulates fusion between endocytic compartments in Xenopus oocytes

1987 • 87 citations

Chinese hamster ovary cell mutants with temperature-sensitive defects in endocytosis. I. Loss of function on shifting to the nonpermissive temperature.

1986 • 77 citations

Role of Acidic Intracellular Compartments in the Biosynthesis of Dictyostelium Lysosomal Enzymes

1989 • 70 citations

Pathways involved in targeting and secretion of a lysosomal enzyme in Dictyostelium discoideum.

1985 • 70 citations

Synthesis of related forms of the lysosomal enzyme alpha-mannosidase in Dictyostelium discoideum.

1983 • 61 citations

The mannose 6-phosphate receptor of Chinese hamster ovary cells. Compartmentalization of acid hydrolases in mutants with altered receptors.

1981 • 61 citations

Regulation and secretion of early developmentally controlled enzymes during axenic growth in Dictyostelium discoideum

1981 • 54 citations

Processing and secretion of alpha-mannosidase forms by Dictyostelium discoideum.

1982 • 48 citations

Lysosomal enzymes in Dictyostelium discoideum are transported to lysosomes at distinctly different rates.

1986 • 47 citations

Inhibition of early but not late proteolytic processing events leads to the missorting and oversecretion of precursor forms of lysosomal enzymes in Dictyostelium discoideum.

1988 • 44 citations

Chapter 7 Defining the Intracellular Localization Pathways followed by Lysosomal Enzymes in Dictyostelium discoideum

1987 • 35 citations

Transit of alpha-mannosidase during its maturation in Dictyostelium discoideum.

1985 • 35 citations

The use of tolerization in the production of monoclonal antibodies against minor antigenic determinants

1986 • 34 citations

[65] Secretory mutants in the cellular slime mold Dictyostelium discoideum

1983 • 34 citations

Alkaline phosphatase of Dictyostelium discoideum: Cell surface location and colchicine effect on internalization During phagocytosis

1974 • 33 citations

Mannose 6-sulfate is present in the N-linked oligosaccharides of lysosomal enzymes of Dictyostelium

1985 • 33 citations

Modifications of lysosomal enzymes in Dictyostelium discoideum

1986 • 32 citations

Endo-glycosidase F and peptide N-glycosidase F release the great majority of total cellular N-linked oligosaccharides: Use in demonstrating that sulfated N-linked oligosaccharides are frequently found in cultured cells

1986 • 31 citations

Processing, transport, and secretion of the lysosomal enzyme acid phosphatase in Dictyostelium discoideum

1989 • 30 citations

Initial events involved in the synthesis of the lysosomal enzyme α-mannosidase in Dictyostelium discoideum

1986 • 24 citations

Biosynthesis of methylphosphomannosyl residues in the oligosaccharides of Dictyostelium discoideum glycoproteins. Evidence that the methyl group is derived from methionine.

1986 • 23 citations

A conformationally altered precursor to the lysosomal enzyme alpha-mannosidase accumulates in the endoplasmic reticulum in a mutant strain of Dictyostelium discoideum.

1986 • 22 citations

The α-glucosidases of Dictyostelium discoideum

1981 • 18 citations

Transport and Targeting of Lysosomal Enzymes in Dictyostelium discoideum

1988 • 10 citations

Linked pools of processed alpha-mannosidase in Dictyostelium discoideum.

1983 • 10 citations

Endocytosis and Compartmentalization of Lysosomal Enzymes in Normal and Mutant Mammalian Cells: Mannose 6-Phosphate-Dependent Pathways

1988 • 7 citations