Mechanisms of cancer invasion and metastasis.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts

1972 • 997 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

The Genuine Works of Hippocrates.

1940 • 755 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Cell surface proteins and malignant transformation

1976 • 713 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Cancer metastasis

1982 • 567 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth.

1978 • 487 citations

Die krankhaften Geschwülste

1978 • 482 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells.

1983 • 441 citations

Isolation of a tumor cell laminin receptor

1983 • 426 citations

Laminin receptor on human breast carcinoma cells.

1983 • 419 citations

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.

1981 • 395 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor.

1976 • 357 citations

Isolation of a laminin-binding protein from muscle cell membranes

1983 • 354 citations

Changing Clinical, Pathologic, Therapeutic, and Survival Patterns in Differentiated Thyroid Carcinoma

1976 • 343 citations

Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.

1984 • 342 citations

Role of collagenases in tumor cell invasion

1982 • 340 citations

Role of laminin in the attachment and metastasis of murine tumor cells.

1982 • 334 citations

Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system.

1977 • 307 citations

A multifactorial analysis of melanoma. II. Prognostic factors in patients with stage I (localized) melanoma.

1979 • 287 citations

Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin.

1981 • 271 citations

Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.

1984 • 269 citations

Carcinoma of the oral cavity

1976 • 259 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

1985 • 240 citations

Methylation of a membrane protein involved in bacterial chemotaxis.

1975 • 239 citations

The role of cell adhesion proteins?laminin and fibronectin?in the movement of malignant and metastatic cells

1985 • 236 citations

Complexing of fibronectin glycosaminoglycans and collagen

1980 • 233 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Cancer immunology: the search for specificity.

1982 • 226 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells

1980 • 212 citations

Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages.

1974 • 205 citations

Mechanisms responsible for the origin and distribution of blood-borne tumor metastases: a review.

1953 • 201 citations

Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

1983 • 199 citations

The significance of the circulating cancer cell

1975 • 196 citations

Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis

1982 • 195 citations

Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment.

1982 • 182 citations

Collagenolytic enzymes in human neoplasms.

1972 • 177 citations

Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell.

1985 • 175 citations

Proteinases and tumor invasion

1980 • 170 citations

QUANTITATION AND IMMUNOCYTOCHEMICAL LOCALIZATION OF HUMAN SKIN COLLAGENASE IN BASAL CELL CARCINOMA

1977 • 166 citations

Tumor invasion and metastasis.

1986 • 156 citations

Secretion of proteinases from malignant and nonmalignant human breast tissue.

1980 • 156 citations

Degradation of Basement Membrane by Murine Tumor Cells2

1977 • 156 citations

Small molecular weight β1 serum protein which specifically inhibits human collagenases

1976 • 147 citations

Relationship Between Metastatic Potential and Resistance to Natural Killer Cellmediated Cytotoxicity in Three Murine Tumor Systems2, 3

1981 • 142 citations

Factors in the Production and Growth of tumor Metastases.

1913 • 128 citations

Proteoglycan changes in the intercellular matrix of human colon carcinoma: an integrated biochemical and stereologic analysis.

1982 • 128 citations

Carcinoma of the colon and rectum: Circulating malignant cells and five-year survival

1973 • 117 citations

Die Entwicklung der Carcinome

1867 • 111 citations

Binding of soluble type I collagen molecules to the fibroblast plasma membrane

1979 • 106 citations

Karyotypic progression in human tumors

1983 • 104 citations

On the antiquity of melanoma

1966 • 101 citations

Extracellular matrix proteins characterize human tumor cell lines

1981 • 92 citations

Tumor Metastasis Is Not Due to Adaptation of Cells to a New Organ Environment

1982 • 89 citations

Identification of a type V collagenolytic enzyme

1981 • 86 citations

Random and nonrandom processes in metastasis, and metastatic inefficiency.

1983 • 84 citations

A history of pathology

1928 • 81 citations

Collagenase Activity in Epidermoid Carcinoma of the Oral Cavity and Larynx

1975 • 71 citations

Characterization of a laminin receptor from human breast carcinoma tissue

1984 • 67 citations

Biological markers of neoplasia : basic and applied aspects

1978 • 67 citations

The invasive growth of malignant tumours as a purely mechanical process

1973 • 66 citations

Phospholipid metabolism, calcium flux, and the receptor-mediated induction of chemotaxis in rabbit neutrophils.

1982 • 64 citations

Collagenase ? A marker enzyme in human bladder cancer?

1979 • 62 citations

Endocrine organ metastases from breast carcinoma.

1984 • 59 citations

Differential proteolytic susceptibility of laminin alpha and beta subunits

1982 • 59 citations

Reduction of tumour cell entry into vessels by BCG-activated macrophages

1977 • 56 citations

Immunotherapy of Metastases Enhances Subsequent Chemotherapy

1982 • 55 citations

Ancient Egyptian Pathology

1963 • 47 citations

Urine Hydroxyproline Excretion-a Marker of Bone Metastases in Prostatic Carcinoma

1977 • 43 citations

Immunology of metastasis

1983 • 38 citations

Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro.

1984 • 36 citations

Invasion of Vascular Endothelial Cell Monolayers and Underlying Matrix by Metastatic Human Cancer Cells

1981 • 25 citations

Identification of a chemoattractant for fibroblasts produced by human breast carcinoma cell lines.

1984 • 24 citations

Differences in the physical properties of collagenases isolated from rheumatoid synovium and human skin

1973 • 23 citations

Invasiveness and tumorigenicity of MO4 mouse fibrosarcoma cells pretreated with microtubule inhibitors

1983 • 17 citations

Experimental systems for analysis of the surface properties of metastatic tumor cells.

1983 • 15 citations

Cultured tumor cells produce chemotactic factors specific for endothelial cells: a possible mechanism for tumor-induced angiogenesis.

1983 • 12 citations

Identification and partial characterization of a low-molecular-weight inhibitor of leukotaxis from fibrosarcoma cells.

1984 • 10 citations

The historical relationship between the concept of tumor and the ending -oma.

1950 • 9 citations

[Proteases and tumor invasion].

1990 • 5 citations

Review : Adjuvant use of cytotoxic chemotherapy to destroy micrometastasis in breast cancer after local control therapy?current status

1983 • 5 citations

Observations on collagenous stroma formation of desmoplastic breast carcinoma.

1975 • 3 citations